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2025
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Medicine
Canada
2026

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Best Scientists

D-Index
174
Citations
126527
World Ranking
741
National Ranking
17

Medicine

D-Index
174
Citations
125448
World Ranking
454
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Medicine in Canada Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Canada Leader Award
  • 2023 - Research.com Medicine in Canada Leader Award
  • 2022 - Research.com Medicine in Canada Leader Award
  • 2000 - Canada Gairdner International Award
  • 1999 - Fellow of the Royal Society of Canada Academy of Science
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jack Hirsh is affiliated with McMaster University in Canada and has a research focus primarily in Medicine, with a significant emphasis on Cardiology and Cardiovascular Medicine. Their body of work includes contributions to subfields such as Internal Medicine, Immunology, Surgery, and Pulmonary and Respiratory Medicine.

The scientist's research topics cover several areas with notable attention to:

  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac electrophysiology and arrhythmias
  • Atherosclerosis and Cardiovascular Diseases
  • Acute Myocardial Infarction Research
  • Antiplatelet Therapy and Cardiovascular Diseases

Frequent coauthors in their research collaborations include:

  • Noel Chan
  • John W. Eikelboom
  • Vinai Bhagirath
  • Tim A.C. de Vries
  • Jeffrey S. Ginsberg

The scientist has published in a variety of journals and frequently appears in the following venues:

  • Thrombosis and Haemostasis
  • Canadian Journal of Cardiology
  • Seminars in Thrombosis and Hemostasis
  • TH Open
  • Journal of Thrombosis and Haemostasis

Recent papers by Jack Hirsh include:

  • "Peripheral Oxygen Saturation in Older Persons Wearing Nonmedical Face Masks in Community Settings" (2020) published in JAMA
  • "Apixaban for Stroke Prevention in Atrial Fibrillation: Why are Event Rates Higher in Clinical Practice than in Randomized Trials?-A Systematic Review" (2020) published in Thrombosis and Haemostasis
  • "Inflammation as a Mechanism and Therapeutic Target in Peripheral Artery Disease" (2022) published in Canadian Journal of Cardiology
  • "Clinical Studies with Anticoagulants that Have Changed Clinical Practice" (2023) published in Seminars in Thrombosis and Hemostasis
  • "The historical origins of modern international normalized ratio targets" (2024) published in Journal of Thrombosis and Haemostasis

Throughout the career, Jack Hirsh has been recognized with several awards, including the Canada Gairdner International Award in 2000, induction as a Fellow of the Royal Society of Canada in 1999 within the Academy of Science, and membership in the Association of American Physicians.

Best Publications

  • American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy

    Jack Hirsh;Valentin Fuster;Jack Ansell;Jonathan L. Halperin

  • Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine

    Gordon Guyatt;John Cairns;David Churchill;Deborah Cook

  • Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin

    Theodore E. Warkentin;Mark N. Levine;Jack Hirsh;Peter Horsewood

  • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

    Jack Ansell;Jack Hirsh;Elaine Hylek;Alan Jacobson

  • Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range

    Jack Hirsh;James E. Dalen;David R. Anderson;Leon Poller

  • The Pharmacology and Management of the Vitamin K Antagonists : The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

    Jack Ansell;Jack Hirsh;Leon Poller;Henry Bussey

  • Derivation of a Simple Clinical Model to Categorize Patients Probability of Pulmonary Embolism: Increasing the Models Utility with the SimpliRED D-dimer

    Philip S. Wells;David R. Anderson;Marc Rodger;Jeffrey S. Ginsberg

  • Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety

    Jack Hirsh;Theodore E. Warkentin;Stephen G. Shaughnessy;Sonia S. Anand

  • A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis.

    Mark Levine;Michael Gent;Jack Hirsh;Jacques Leclerc

  • Aspirin-Resistant Thromboxane Biosynthesis and the Risk of Myocardial Infarction, Stroke, or Cardiovascular Death in Patients at High Risk for Cardiovascular Events

    John W. Eikelboom;Jack Hirsh;Jeffrey I. Weitz;Marilyn Johnston

  • Heparin and Low-Molecular-Weight Heparin: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

    Jack Hirsh;Robert Raschke

  • A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.

    Clive Kearon;Michael Gent;Michael Gent;Jack Hirsh;Jack Hirsh;Jeffrey Weitz

  • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

    J I Weitz;M Hudoba;D Massel;J Maraganore

  • Use of a clinical model for safe management of patients with suspected pulmonary embolism.

    Philip S. Wells;Jeffrey S. Ginsberg;David R. Anderson;Clive Kearon

  • Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety.

    Jack Hirsh;Theodore E. Warkentin;Robert Raschke;Christopher Granger

  • A Comparison of Two Intensities of Warfarin for the Prevention of Recurrent Thrombosis in Patients with the Antiphospholipid Antibody Syndrome

    Mark A. Crowther;Jeff S. Ginsberg;Jim Julian;Judah Denburg

  • Accuracy of clinical assessment of deep-vein thrombosis

    PhilipS. Wells;Jack Hirsh;DavidR. Anderson;AnthonyW.A. Lensing

  • Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

    Shannon M. Bates;Ian A. Greer;Ingrid Pabinger;Shoshanna Sofaer

  • Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

    Carlo Patrono;Colin Baigent;Jack Hirsh;Gerald Roth

  • Low-molecular-weight heparin in the treatment of patients with venous thromboembolism

    JW tenCate;HR Buller;M Gent;J Hirsh

Frequent Co-Authors

Jeffrey S. Ginsberg
Jeffrey S. Ginsberg McMaster University
Michael Gent
Michael Gent McMaster University
John W. Eikelboom
John W. Eikelboom Population Health Research Institute
Alexander G.G. Turpie
Alexander G.G. Turpie McMaster University
Jeffrey I. Weitz
Jeffrey I. Weitz McMaster University
Mark Levine
Mark Levine McMaster University
Frederick A. Ofosu
Frederick A. Ofosu McMaster University
Clive Kearon
Clive Kearon McMaster University
Russell D. Hull
Russell D. Hull University of Calgary
Morris A. Blajchman
Morris A. Blajchman McMaster University

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