World's Best Scientists 2026 revealed!
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Microbiology
South Africa
2026

D-Index & Metrics

Microbiology

D-Index
100
Citations
34173
World Ranking
414
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Microbiology in South Africa Leader Award
  • 2025 - Research.com Microbiology in South Africa Leader Award

Overview

Paul D. van Helden is affiliated with Stellenbosch University in South Africa and has a research focus spanning medicine and biochemistry, genetics, and molecular biology. Their work predominantly covers infectious diseases, with emphasized expertise in tuberculosis research and epidemiology.

The scientist's publication record includes research on topics such as:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Microbial infections and disease research
  • Genetic and phenotypic traits in livestock
  • Infectious Diseases and Tuberculosis
  • Genomics and Phylogenetic Studies
  • Diagnosis and treatment of tuberculosis

Van Helden has published extensively in journals that include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • UNC Libraries
  • Transboundary and Emerging Diseases
  • Journal of Medicinal Chemistry

Frequent collaborators in their research include:

  • Robin M. Warren
  • Michele A. Miller (21)
  • Tanya J. Kerr (17)
  • Wynand J. Goosen (16)
  • Peter Buss (15)

Recent papers authored or co-authored by van Helden focus primarily on tuberculosis diagnosis, epidemiology, and microbiological studies, with notable publications such as:

  • "Xpert MTB/RIF Ultra and Xpert MTB/RIF for diagnosis of tuberculosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study" (2020), published in The Lancet Respiratory Medicine
  • "Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis" (2020), published in Nature Medicine
  • "Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife" (2021), published in Frontiers in Veterinary Science
  • "Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis" (2021), published in EBioMedicine
  • "The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana)" (2020), published in Scientific Reports

Best Publications

  • Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

    Karine Brudey;Jeffrey R Driscoll;Leen Rigouts;Wolfgang M Prodinger

  • Exogenous Reinfection as a Cause of Recurrent Tuberculosis after Curative Treatment

    A van Rie;R Warren;M Richardson;T C Victor

  • The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

    Keertan Dheda;Tawanda Gumbo;Gary Maartens;Kelly E. Dooley

  • Rate of Reinfection Tuberculosis after Successful Treatment Is Higher than Rate of New Tuberculosis

    Suzanne Verver;Robin M. Warren;Nulda Beyers;Madalene Richardson

  • Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions

    Nicolaas C Gey van Pittius;Samantha L Sampson;Hyeyoung Lee;Yeun Kim

  • Zoonotic Mycobacterium bovis - induced tuberculosis in humans.

    Borna Müller;Salome Esther Dürr;Silvia Alonso;Jan Hattendorf

  • Mycobacterium bovis at the animal-human interface: a problem, or not?

    Anita Luise Michel;Borna Müller;Paul David van Helden

  • Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

    Francesc Coll;Jody Phelan;Grant A Hill-Cawthorne;Grant A Hill-Cawthorne;Mridul B Nair

  • Patients with active tuberculosis often have different strains in the same sputum specimen.

    Robin M. Warren;Thomas C. Victor;Elizabeth M. Streicher;Madalene Richardson

  • Proportion of tuberculosis transmission that takes place in households in a high-incidence area.

    Suzanne Verver;Robin M Warren;Zahn Munch;Madalene Richardson

  • Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference.

    R M Warren;N C Gey van Pittius;M Barnard;A Hesseling

  • Drug resistance in Mycobacterium tuberculosis.

    Rabia Johnson;Elizabeth M Streicher;Gail E Louw;Robin M Warren

  • Novel Mycobacterium tuberculosis complex pathogen, M. mungi

    Kathleen A. Alexander;Pete N. Laver;Anita Luise Michel;Mark C. Williams

  • A balancing act: efflux/influx in mycobacterial drug resistance.

    G. E. Louw;R. M. Warren;N. C. Gey van Pittius;C. R. E. McEvoy

  • Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.

    Marisa Klopper;Robin Mark Warren;Cindy Hayes;Nicolaas Claudius Gey van Pittius

  • Association between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene

    Manda Rossouw;Hendrik J Nel;Graham S Cooke;Paul D van Helden

  • Hypomethylation of DNA in pathological conditions of the human prostate

    M T Bedford;P D van Helden

  • Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission

    M. de Vos;B. Müller;B. Müller;B. Müller;S. Borrell;S. Borrell;P. A. Black

  • Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis

    Luis B Barreiro;Olivier Neyrolles;Chantal L Babb;Ludovic Tailleux

  • Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.

    Jacqueline M. Cliff;Ji-Sook Lee;Nicholas Constantinou;Jang-Eun Cho

  • Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area

    Philip Supply;Robin M. Warren;Anne-Laure Bañuls;Sarah Lesjean

Frequent Co-Authors

Robin M. Warren
Robin M. Warren Stellenbosch University
Thomas C. Victor
Thomas C. Victor Stellenbosch University
Nulda Beyers
Nulda Beyers Stellenbosch University
Gerhard Walzl
Gerhard Walzl Stellenbosch University
Anita Luise Michel
Anita Luise Michel University of Pretoria
Hazel M. Dockrell
Hazel M. Dockrell London School of Hygiene & Tropical Medicine
Gunilla Källenius
Gunilla Källenius Karolinska Institute
Arnab Pain
Arnab Pain King Abdullah University of Science and Technology
Laurent Abel
Laurent Abel Université Paris Cité
Stefan H. E. Kaufmann
Stefan H. E. Kaufmann Max Planck Institute for Infection Biology

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