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Biology and Biochemistry

D-Index
59
Citations
12951
World Ranking
12495
National Ranking
5348

Overview

Tawanda Gumbo is affiliated with Baylor University Medical Center in the United States and has contributed extensively to the field of medicine, with a primary focus on infectious diseases. Their research spans several closely related subfields, including infectious diseases, epidemiology, pharmacology, organic chemistry, and molecular medicine.

Their main topics of research are centered around tuberculosis and associated areas such as Mycobacterium research and diagnosis, antibiotics pharmacokinetics and efficacy, quinazolinone synthesis and applications, antibiotic resistance in bacteria, infectious diseases and tuberculosis, as well as drug transport and resistance mechanisms.

Frequent publication venues for Gumbo include:

  • Antimicrobial Agents and Chemotherapy
  • Frontiers in Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Antimicrobial Chemotherapy
  • Open Forum Infectious Diseases

The scientist has authored several recent papers, demonstrating active engagement in tuberculosis-related research. Selected publications include:

  • Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions, 2020, Nature Medicine
  • Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis, 2020, Nature Medicine
  • Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis, 2021, International Journal of Infectious Diseases
  • Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment, 2022, European Respiratory Journal
  • Omadacycline efficacy in the hollow fibre system model of pulmonary Mycobacterium avium complex and potency at clinically attainable doses, 2022, Journal of Antimicrobial Chemotherapy

Gumbo frequently collaborates with several coauthors, including:

  • Shashikant Srivastava
  • Gunavanthi D. Boorgula
  • Sanjay Singh
  • Devyani Deshpande
  • Jotam G. Pasipanodya

Best Publications

  • Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore

    Paul G. Ambrose;Sujata M. Bhavnani;Christopher M. Rubino;Arnold Louie

  • The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

    Keertan Dheda;Tawanda Gumbo;Gary Maartens;Kelly E. Dooley

  • Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes

    Jotam G. Pasipanodya;Helen McIlleron;André Burger;Peter A. Wash

  • Selection of a Moxifloxacin Dose That Suppresses Drug Resistance in Mycobacterium tuberculosis, by Use of an In Vitro Pharmacodynamic Infection Model and Mathematical Modeling

    Tawanda Gumbo;Arnold Louie;Mark R. Deziel;Linda M. Parsons

  • Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

    Tawanda Gumbo;Arnold Louie;Mark R. Deziel;Weiguo Liu

  • Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis.

    Keertan Dheda;Tawanda Gumbo;Neel R Gandhi;Megan Murray

  • Multidrug-Resistant Tuberculosis Not Due to Noncompliance but to Between-Patient Pharmacokinetic Variability

    Shashikant Srivastava;Jotam G. Pasipanodya;Claudia Meek;Richard Leff

  • Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy

    Jotam G. Pasipanodya;Shashikant Srivastava;Tawanda Gumbo

  • Pharmacodynamics of Caspofungin in a Murine Model of Systemic Candidiasis: Importance of Persistence of Caspofungin in Tissues to Understanding Drug Activity

    Arnold Louie;Mark Deziel;Weiguo Liu;Michael F. Drusano

  • Pharmacokinetics-Pharmacodynamics of Pyrazinamide in a Novel In Vitro Model of Tuberculosis for Sterilizing Effect: a Paradigm for Faster Assessment of New Antituberculosis Drugs

    Tawanda Gumbo;Chandima S. W. Siyambalapitiyage Dona;Claudia Meek;Richard Leff

  • The Antibiotic Resistance Arrow of Time: Efflux Pump Induction Is a General First Step in the Evolution of Mycobacterial Drug Resistance

    Aurelia M. Schmalstieg;Shashikant Srivastava;Serkan Belkaya;Devyani Deshpande

  • Isoniazid bactericidal activity and resistance emergence: integrating pharmacodynamics and pharmacogenomics to predict efficacy in different ethnic populations.

    Tawanda Gumbo;Arnold Louie;Weiguo Liu;David Brown

  • Efflux-Pump-Derived Multiple Drug Resistance to Ethambutol Monotherapy in Mycobacterium tuberculosis and the Pharmacokinetics and Pharmacodynamics of Ethambutol

    Shashikant Srivastava;Sandirai Musuka;Carleton Sherman;Claudia Meek

  • New Susceptibility Breakpoints for First-Line Antituberculosis Drugs Based on Antimicrobial Pharmacokinetic/Pharmacodynamic Science and Population Pharmacokinetic Variability

    Tawanda Gumbo

  • A Meta-Analysis of Self-Administered vs Directly Observed Therapy Effect on Microbiologic Failure, Relapse, and Acquired Drug Resistance in Tuberculosis Patients

    Jotam G. Pasipanodya;Tawanda Gumbo

  • Population Pharmacokinetics of Micafungin in Pediatric Patients and Implications for Antifungal Dosing

    William W. Hope;Nita L. Seibel;Cindy L. Schwartz;Antonio Arrieta

  • Intestinal parasites in patients with diarrhea and human immunodeficiency virus infection in Zimbabwe

    Tawanda Gumbo;Steedman Sarbah;Innocent T. Gangaidzo;Ynes Ortega

  • Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

    Emmanuel Chigutsa;Jotam G. Pasipanodya;Marianne E. Visser;Paul D. van Helden

  • Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

    Keertan Dheda;Laura Lenders;Gesham Magombedze;Shashikant Srivastava

  • Isoniazid's Bactericidal Activity Ceases because of the Emergence of Resistance, Not Depletion of Mycobacterium tuberculosis in the Log Phase of Growth

    Tawanda Gumbo;Arnold Louie;Weiguo Liu;Paul G. Ambrose

Frequent Co-Authors

Keertan Dheda
Keertan Dheda University of Cape Town
Eric L. Nuermberger
Eric L. Nuermberger Johns Hopkins University
George L. Drusano
George L. Drusano University of Florida
Gary Maartens
Gary Maartens University of Cape Town
Robin M. Warren
Robin M. Warren Stellenbosch University
Soumya Swaminathan
Soumya Swaminathan M S Swaminathan Research Foundation
Johan W. Mouton
Johan W. Mouton Radboud University Medical Center
Sujata M. Bhavnani
Sujata M. Bhavnani University at Buffalo, State University of New York
Dick van Soolingen
Dick van Soolingen National Institute for Public Health and the Environment
Edward K. Wakeland
Edward K. Wakeland The University of Texas Southwestern Medical Center

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