Lori Sussel

Overview

Best Publications

• Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

  Chutima Talchai;Shouhong Xuan;Hua V. Lin;Lori Sussel

  1733
  Citations

• Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

  L. Sussel;O. Marin;S. Kimura;J. L. R. Rubenstein

  1293
  Citations

• β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

  Philippe A. Halban;Kenneth S. Polonsky;Donald W. Bowden;Meredith A. Hawkins

  1164
  Citations

• Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

  Angela J Churchill;Giselle Dominguez Gutiérrez;Ruth A Singer;David S Lorberbaum

  1088
  Citations

• Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

  J. Briscoe;L. Sussel;P. Serup;D. Hartigan-O'Connor

  921
  Citations

• Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.

  Valérie M. Schwitzgebel;David W. Scheel;Jennifer R. Conners;Julie Kalamaras

  866
  Citations

• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

  L. Sussel;J. Kalamaras;D. J. Hartigan-O'connor;J. J. Meneses

  771
  Citations

• Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

  M. Sander;L. Sussel;J. Conners;D. Scheel

  670
  Citations

• A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.

  C. F. J. Hardy;L. Sussel;D. Shore

  658
  Citations

• Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development

  Catherine L. Prado;Aimee E. Pugh-Bernard;Lynda Elghazi;Beatriz Sosa-Pineda

  653
  Citations

• Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

  Ignasi Morán;İldem Akerman;Martijn van de Bunt;Martijn van de Bunt;Ruiyu Xie

  480
  Citations

• Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.

  Yingchuan Qi;Jun Cai;Yuanyuan Wu;Rui Wu

  433
  Citations

• A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

  Nilima Prakash;Claude Brodski;Thorsten Naserke;Eduardo Puelles

  314
  Citations

• Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

  Chunyan Gu;Gretchen H. Stein;Ning Pan;Sandra Goebbels

  307
  Citations

• Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.

  Lori Sussel;David Shore

  300
  Citations

• β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

  Laura I. Hudish;Jane E.B. Reusch;Lori Sussel

  255
  Citations

• Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

  James B. Papizan;Ruth A. Singer;Shuen-Ing Tschen;Sangeeta Dhawan

  223
  Citations

• Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development.

  Mengsheng Qiu;Kenji Shimamura;Lori Sussel;Sandy Chen

  217
  Citations

• The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.

  Junfeng Wang;Lynda Elghazi;Susan E Parker;Hasan Kizilocak

  203
  Citations

• b-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and

  Universityof Geneva;Philippe A. Halban;Kenneth S. Polonsky;Donald W. Bowden

  0
  Citations