World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
47
Citations
10735
World Ranking
15498
National Ranking
129

Overview

Carlos A.M. Fraga is affiliated with the Federal University of Rio de Janeiro in Brazil. Their research predominantly intersects the domains of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. Their work spans several subfields, notably Molecular Biology, Organic Chemistry, Oncology, Pharmacology, and Physiology.

Their scientific contributions manifest extensively in topics such as Histone Deacetylase Inhibitors Research, Computational Drug Discovery Methods, Cholinesterase and Neurodegenerative Diseases, Peptidase Inhibition and Analysis, Melanoma and MAPK Pathways, and Synthesis and Biological Evaluation.

Frequent publication venues for Carlos A.M. Fraga include:

  • Pharmaceuticals
  • Circulation Research
  • ACS Omega
  • Preprints.org
  • SSRN Electronic Journal

Notable recent papers authored or co-authored by Carlos A.M. Fraga include:

  • "Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry," 2023, published in Molecules
  • "Molecular hybridization: a powerful tool for multitarget drug discovery," 2024, published in Expert Opinion on Drug Discovery
  • "The Magic Methyl and Its Tricks in Drug Discovery and Development," 2023, published in Pharmaceuticals
  • "Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities," 2020, published in Medicinal Research Reviews
  • "Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors," 2020, published in ChemMedChem

Collaborations form a regular part of their research activities, with frequent co-authors including:

  • Pedro de Sena Murteira Pinheiro
  • Daniel Alencar Rodrigues
  • Lí dia Moreira Lima
  • Tadeu L. Montagnoli
  • Carlos Maurício R. Sant'Anna

Best Publications

  • Molecular hybridization: A useful tool in the design of new drug prototypes

    Claudio Viegas-Junior;Amanda Danuello;Vanderlan da Silva Bolzani;Eliezer J. Barreiro

  • The methylation effect in medicinal chemistry.

    Eliezer J. Barreiro;Arthur E. Kümmerle;Carlos A. M. Fraga

  • From nature to drug discovery: the indole scaffold as a 'privileged structure'.

    Fernando Rodrigues de Sa Alves;Eliezer J. Barreiro;Carlos Alberto Manssour Fraga

  • Privileged structures: a useful concept for the rational design of new lead drug candidates.

    Carolina D. Duarte;Eliezer J. Barreiro;Carlos A.M. Fraga

  • Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole.

    P. C. Lima;L. M. Lima;K. C. M. Da Silva;P. H. O. Leda

  • Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues.

    Lı́dia M Lima;Paulo Castro;Alexandre L Machado;Carlos Alberto M Fraga

  • Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives.

    Anna C. Cunha;Juliana M. Figueiredo;Jorge L.M. Tributino;Ana L.P. Miranda

  • Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes.

    Renata B. Lacerda;Cleverton K.F. de Lima;Leandro L. da Silva;Nelilma C. Romeiro

  • N-Acylhydrazones as drugs.

    Sreekanth Thota;Sreekanth Thota;Daniel A. Rodrigues;Pedro de Sena Murteira Pinheiro;Lídia M. Lima

  • New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives

    Gildásio A. Silva;Luciana M.M. Costa;Fernanda C.F. Brito;Ana L.P. Miranda

  • Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer

    Cláudio Viegas Junior;Vanderlan da Silva Bolzani;Maysa Furlan;Carlos Alberto Manssour Fraga

  • Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.

    Arthur E Kümmerle;Martine Schmitt;Suzana V S Cardozo;Suzana V S Cardozo;Claire Lugnier

  • Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues

    Alexandre G. Silva;Gisele Zapata-Sudo;Arthur E. Kummerle;Carlos A.M. Fraga

  • Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres: A New Class of Potent and Selective Acetylcholinesterase Inhibitors

    Eliezer J Barreiro;Celso A Camara;Hugo Verli;Leonora Brazil-Más

  • Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs.

    Carlos A. M. Fraga;Eliezer J. Barreiro

  • The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease.

    Miguel Divino da Rocha;Flavia Pereira Dias Viegas;Helineide Cristina Campos;Patricia Carolina Nicastro

  • Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives.

    Alexandra Basilio Lopes;Eduardo Miguez;Arthur Eugen Kümmerle;Victor Marcos Rumjanek

  • Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors

    Daniel A. Rodrigues;Guilherme À. Ferreira-Silva;Ana C. S. Ferreira;Renan A. Fernandes

  • Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands.

    Ricardo Menegatti;Anna C Cunha;Vı́tor F Ferreira;Edna F.R Perreira

  • Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: new lead-agents with analgesic and antipyretic properties.

    Heleno J.C. Bezerra-Netto;Daniel I. Lacerda;Ana Luisa P. Miranda;Hélio M. Alves

  • Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues.

    Samir A. Carvalho;Edson F. da Silva;Ricardo M. Santa-Rita;Ricardo M. Santa-Rita;Solange L. de Castro;Solange L. de Castro

Frequent Co-Authors

Eliezer J. Barreiro
Eliezer J. Barreiro Federal University of Rio de Janeiro
Solange L. de Castro
Solange L. de Castro Oswaldo Cruz Foundation
Vanderlan da Silva Bolzani
Vanderlan da Silva Bolzani Sao Paulo State University
Edson X. Albuquerque
Edson X. Albuquerque University of Maryland, Baltimore
Edward R. T. Tiekink
Edward R. T. Tiekink Sunway University
Etelvino J. H. Bechara
Etelvino J. H. Bechara Universidade de São Paulo
Russolina B. Zingali
Russolina B. Zingali Federal University of Rio de Janeiro
Reto Brun
Reto Brun University of Basel
Daniel Rauh
Daniel Rauh TU Dortmund University
Christian Becker
Christian Becker University of Cologne

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens doors to a variety of specialized career paths that often require further education. For those interested in healthcare, understanding how do you become a pharmacist is essential, as pharmacists rely heavily on chemical knowledge to dispense medications safely and effectively.

Another intriguing option is forensic science, where chemistry skills are applied to solve crimes. Students can explore best online colleges for forensic science to find flexible pathways for earning their degrees while gaining relevant expertise.

Careers like autopsy technician blend biology, chemistry, and investigative work. Insight into the autopsy tech salary and job outlook helps prospective students weigh the benefits of pursuing this path.

For those fascinated by human behavior alongside chemistry, online programs such as forensic psychology master's programs online offer opportunities to advance in forensic and psychological analysis, complementing a chemistry background.

Best Scientists Citing Carlos A.M. Fraga

Trending Scientists