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Biology and Biochemistry

D-Index
50
Citations
10303
World Ranking
17548
National Ranking
7202

Overview

Debra D. Pittman is affiliated with Pfizer in the United States. Their research primarily focuses on multiple areas within medicine, with a significant emphasis on hematology. Over their career, Pittman has contributed extensively to fields including genetics, pediatrics, perinatology and child health, nutrition and dietetics, and biomedical engineering.

The scientist's work covers a range of topics such as hemoglobinopathies and related disorders, iron metabolism and disorders, hemophilia treatment and research, blood coagulation and thrombosis mechanisms, virus-based gene therapy research, platelet disorders and treatments, and blood groups and transfusion.

Pittman has authored papers published in various journals, predominantly in Blood and Research and Practice in Thrombosis and Haemostasis, with additional publications in Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis, and European Journal of Haematology. Notable recent publications include:

  • "Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia," 2020, Blood
  • "Evaluation of Longitudinal Pain Study in Sickle Cell Disease (ELIPSIS) by patient-reported outcomes, actigraphy, and biomarkers," 2020, Blood
  • "Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation," 2020, Journal of Thrombosis and Haemostasis
  • "Hemostatic efficacy of marstacimab alone or in combination with bypassing agents in hemophilia plasmas and a mouse bleeding model," 2022, Research and Practice in Thrombosis and Haemostasis
  • "Field Study and Correlative Studies of Factor IX Variant FIX-R338L in Participants Treated with Fidanacogene Elaparvovec," 2024, Thrombosis and Haemostasis

Frequent co-authors collaborating with Pittman include Swapnil Rakhe, Steven Arkin, John E. Murphy, Denis Rybin, and Michael U. Callaghan, indicating a collaborative research environment spanning multiple studies.

Best Publications

  • Molecular cloning of a cDNA encoding human antihaemophilic factor.

    Toole Jj;Knopf Jl;Wozney Jm;Sultzman La

  • Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

    Edmund Jd Lee;William L. Trepicchio;Judith L Oestreicher;Debra D Pittman

  • Complete cDNA and derived amino acid sequence of human factor V.

    Richard J. Jenny;Debra D. Pittman;John J. Toole;Ronald W. Kriz

  • A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity

    John J. Toole;Debra D. Pittman;Elizabeth C. Orr;Patricia Murtha

  • Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII

    Debra D. Pittman;Edward M. Alderman;Kathleen N. Tomkinson;Jack H. Wang

  • Hemophilia A Detection of Molecular Defects and of Carriers by DNA Analysis

    Stylianos E. Antonarakis;Pamela G. Waber;Smita D. Kittur;Achyut S. Patel

  • Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).

    Debra D. Pittman;Randal J. Kaufman

  • The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

    Robert J. Wise;Robert J. Wise;Debra D. Pittman;Robert I. Handin;Randal J. Kaufman

  • In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector.

    Tord D. Alden;Debra D. Pittman;Gerald R. Hankins;Elisa J. Beres

  • Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

    Emily C Lutterloh;Steven M Opal;Debra D Pittman;James C Keith

  • IL-22 Induces an Acute-Phase Response

    Spencer C. Liang;Cheryl Nickerson-Nutter;Debra D. Pittman;Yijun Carrier

  • The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

    R J Wise;A J Dorner;M Krane;D D Pittman

  • Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy.

    Tord D. Alden;Debra D. Pittman;Elisa J. Beres;Gerald R. Hankins

  • Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat.

    J Z Li;H Li;T Sasaki;D Holman

  • Human CTLA-8 and uses of CTLA-8-related proteins

    Kenneth Jacobs;Kerry Kelleher;McKeough Carlin;Samuel Goldman

  • Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.

    D A Michnick;D D Pittman;R J Wise;R J Kaufman

  • Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent.

    Gregory A. Helm;Tord D. Alden;Elisa J. Beres;Sarah B. Hudson

  • Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.

    D.D. Pittman;K.N. Tomkinson;R.J. Kaufman

  • Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII.

    Debra D. Pittman;Jack H. Wang;Randal J. Kaufman

  • Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

    William J. Finlay;Orla Cunningham;Matthew A. Lambert;Alfredo Darmanin-Sheehan

Frequent Co-Authors

Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
John M. Wozney
John M. Wozney Pfizer (Canada)
David F. Kallmes
David F. Kallmes Mayo Clinic
Steven M. Opal
Steven M. Opal Brown University
Fionula M. Brennan
Fionula M. Brennan University of Oxford
Marc Feldmann
Marc Feldmann University of Oxford
Alan D. Michelson
Alan D. Michelson Harvard University
Mary Collins
Mary Collins Queen Mary University of London
Stuart H. Orkin
Stuart H. Orkin Harvard University
Kenneth G. Mann
Kenneth G. Mann University of Vermont

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