World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
51
Citations
12027
World Ranking
13805
National Ranking
1012

Overview

Patrick Y. S. Lam is affiliated with Bristol-Myers Squibb in Germany. Their research spans multiple areas within the fields of Medicine and Chemistry, with a primary focus on Organic Chemistry, Epidemiology, Hepatology, Biochemistry, and Ecology.

The scientist's recent publications illustrate a broad engagement with both chemical synthesis and biomedical studies. These works include:

  • Advances in Carbon-Element Bond Construction under Chan-Lam Cross-Coupling Conditions: A Second Decade, 2020, published in Synthesis
  • Prevalence of simian malaria parasites in macaques of Singapore, 2021, published in PLoS neglected tropical diseases
  • Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure, 2021, published in Cardiovascular Research
  • Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species, 2020, published in Journal of Medicinal Chemistry
  • Survey of rodent-borne pathogens in Singapore reveals the circulation of Leptospira spp., Seoul hantavirus, and Rickettsia typhi, 2022, published in Scientific Reports

Lam's research covers a range of topics including:

  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Sulfur Compounds in Biology
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Peptidase Inhibition and Analysis
  • Catalytic C-H Functionalization Methods
  • Catalytic Cross-Coupling Reactions

Frequent co-authors in Lam's work include:

  • Nicky Hwang
  • Yanming Du
  • Diyar Mailepessov
  • Lee Ching Ng
  • Michael R. Jackson

Publications by Lam have appeared in various scientific venues, predominantly:

  • Bioorganic & Medicinal Chemistry Letters
  • Synthesis
  • PLoS neglected tropical diseases
  • Cardiovascular Research
  • Scientific Reports

The interdisciplinary nature of Patrick Y. S. Lam's research integrates organic chemistry methodologies with medical and epidemiological investigations, highlighting work on viral hepatitis, biochemical pathways relating to sulfur compounds, and cardiovascular biology. This body of work reflects a combination of chemical synthesis approaches and biomedical applications.

Best Publications

  • New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

    Patrick Y.S Lam;Charles G Clark;Simon Saubern;Jessica Adams

  • Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

    PY Lam;PK Jadhav;CJ Eyermann;CN Hodge

  • Copper-Promoted Carbon-HeteroatomBond Cross-Coupling with Boronic Acids and Derivatives

    Jennifer X. Qiao;Patrick Y. S. Lam

  • Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.

    Donald J.P. Pinto;Michael J. Orwat;Stephanie Koch;Karen A. Rossi

  • Copper-catalyzed general CN and CO bond cross-coupling with arylboronic acid

    Patrick Y.S Lam;Guillaume Vincent;Charles G Clark;Sophie Deudon

  • Flexibility and function in HIV-1 protease

    Nicholson Lk;Yamazaki T;Torchia Da;Grzesiek S

  • Lactam-containing compounds and derivatives thereof as factor xa inhibitors

    Donald J.P. Pinto;Mimi L. Quan;Michael J. Orwat;Yun-Long Li

  • Copper-Promoted C−N Bond Cross-Coupling with Hypervalent Aryl Siloxanes and Room-Temperature N-Arylation with Aryl Iodide

    Patrick Y. S. Lam;Sophie Deudon;Kristin M. Averill;Renhua Li

  • Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.

    Mimi L. Quan;Patrick Y. S. Lam;Qi Han;Donald J. P. Pinto

  • Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

    Donald J. P. Pinto;Michael J. Orwat;Shuaige Wang;John M. Fevig

  • Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

    P. Y. S. Lam;Y. Ru;P. K. Jadhav;P. E. Aldrich

  • Copper-promoted/catalyzed CN and CO bond cross-coupling with vinylboronic acid and its utilities

    Patrick Y.S Lam;Guillaume Vincent;Damien Bonne;Charles G Clark

  • Copper promoted CN and CO bond cross-coupling with phenyl and pyridylboronates

    Dominic M.T. Chan;Kevin L. Monaco;Renhua Li;Damien Bonne

  • Inhibitors of factor Xa with a neutral P1 specificity group

    Robert Anthony Galemmo;Celia Dominguez;John Matthew Fevig;Qi Han

  • Factor xa inhibitors

    Mimi L. Quan;Patrick Y. Lam;Yunlong Li;Donald J. P. Pinto

  • Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

    Hodge Cn;Aldrich Pe;Bacheler Lt;Chang Ch

  • NMR and X-ray Evidence That the HIV Protease Catalytic Aspartyl Groups Are Protonated in the Complex Formed by the Protease and a Non-Peptide Cyclic Urea-Based Inhibitor

    Toshimasa Yamazaki;Linda K. Nicholson;Paul Wingfield;Stephen J. Stahl

  • Solid supported CN cross-coupling reactions

    Andrew P. Combs;Simon Saubern;Maria Rafalski;Patrick Y.S. Lam

  • N-Arylation of α-aminoesters with p-tolylboronic acid promoted by copper(II) acetate

    Patrick Y.S Lam;Damien Bonne;Guillaume Vincent;Charles G Clark

  • Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.

    P. J. Ala;E. E. Huston;R. M. Klabe;D. D. Mccabe

Frequent Co-Authors

Donald J. Cram
Donald J. Cram University of California, Los Angeles
Paul T. Wingfield
Paul T. Wingfield National Institutes of Health
Stephen J. Stahl
Stephen J. Stahl National Institutes of Health
Dennis A. Torchia
Dennis A. Torchia National Institutes of Health
Phil S. Baran
Phil S. Baran Scripps (United States)

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, exploring online degrees in related fields can open up diverse career opportunities. One intriguing path is forensic science, which bridges chemistry with criminal investigations. Pursuing an online masters forensic psychology can complement your chemistry background and enhance your understanding of the psychological factors involved in forensic cases.

Career options in this field are varied. The forensic career paths include roles like forensic chemists, crime lab analysts, and toxicologists. These positions often require specialized knowledge that combines chemistry and criminal justice principles.

Cost is a significant consideration for students seeking such degrees. Understanding the cost of criminal justice degree programs can help you make informed decisions about your education budget and financial planning.

Starting with an online associate degree in criminal justice is another accessible route to enter the field. This degree can provide foundational knowledge and prepare you for advanced studies or entry-level forensic positions.

Best Scientists Citing Patrick Y. S. Lam

Trending Scientists

Recently Published Articles