What is he best known for?
The fields of study he is best known for:
- Organic chemistry
- Enzyme
- Catalysis
The scientist’s investigation covers issues in Stereochemistry, Factor Xa Inhibitor, Protease, Copper and Enzyme.
His biological study spans a wide range of topics, including Proteases, Group, Salt, Structure–activity relationship and Enzyme inhibitor.
His Factor Xa Inhibitor research incorporates elements of Pyrazole, Thrombin and Benzamidine.
His work carried out in the field of Pyrazole brings together such families of science as Bicyclic molecule and Carboxamide.
His Copper study combines topics in areas such as Polymer chemistry and Coupling reaction.
His research investigates the connection between Enzyme and topics such as Anticoagulant Agent that intersect with problems in Discovery and development of direct thrombin inhibitors.
His most cited work include:
- Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors (704 citations)
- New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation (701 citations)
- Copper-Promoted Carbon-HeteroatomBond Cross-Coupling with Boronic Acids and Derivatives (349 citations)
What are the main themes of his work throughout his whole career to date?
Patrick Y.S. Lam mainly focuses on Stereochemistry, Factor Xa Inhibitor, Protease, Pharmacology and Enzyme inhibitor.
His Stereochemistry study combines topics from a wide range of disciplines, such as Structure–activity relationship, Chemical synthesis and Enzyme.
His Factor Xa Inhibitor research is multidisciplinary, incorporating perspectives in Lactam, Salt, Guanidine and Carboxamide.
His Protease research is multidisciplinary, incorporating elements of Urea and Virus.
His work on Bioavailability as part of general Pharmacology study is frequently linked to Fibrinolytic agent, bridging the gap between disciplines.
His Enzyme inhibitor research includes elements of Benzamidine, Amidine, Molecular model and Thrombin.
He most often published in these fields:
- Stereochemistry (43.35%)
- Factor Xa Inhibitor (31.79%)
- Protease (16.18%)
What were the highlights of his more recent work (between 2010-2020)?
- Pharmacology (16.18%)
- Stereochemistry (43.35%)
- Antithrombotic (8.67%)
In recent papers he was focusing on the following fields of study:
Pharmacology, Stereochemistry, Antithrombotic, Combinatorial chemistry and Bioavailability are his primary areas of study.
His work on Pharmacokinetics as part of general Pharmacology research is frequently linked to In vivo, thereby connecting diverse disciplines of science.
In his research, he undertakes multidisciplinary study on Stereochemistry and P2y1 receptor.
His Antithrombotic research is multidisciplinary, relying on both P2Y12, Antagonist, Coagulation, Thrombus and Drug discovery.
His Combinatorial chemistry study integrates concerns from other disciplines, such as Factor XIa, Structure–activity relationship, Imidazole and Enzyme.
Many of his studies on Bioavailability involve topics that are commonly interrelated, such as Factor Xa Inhibitor.
Between 2010 and 2020, his most popular works were:
- Copper-Promoted Carbon-HeteroatomBond Cross-Coupling with Boronic Acids and Derivatives (349 citations)
- Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor (57 citations)
- Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist (40 citations)
In his most recent research, the most cited papers focused on:
- Organic chemistry
- Enzyme
- Catalysis
His primary areas of study are Pharmacology, Stereochemistry, Antithrombotic, Factor XIa and Combinatorial chemistry.
His studies in Pharmacology integrate themes in fields like Clotting time and Potency.
Patrick Y.S. Lam combines subjects such as Selectivity and Bioavailability with his study of Stereochemistry.
His study focuses on the intersection of Antithrombotic and fields such as Antagonist with connections in the field of Piperidine, Indoline, Lead compound, Urea and Platelet.
His Combinatorial chemistry study incorporates themes from Carbon, Chemical synthesis, Chemical coupling and Reaction mechanism.
His work deals with themes such as Chan-Lam coupling, Coupling reaction and Copper, which intersect with Chemical coupling.
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