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Joseph J. Locascio

Joseph J. Locascio

D-Index & Metrics

Neuroscience

D-Index
61
Citations
16004
World Ranking
3636
National Ranking
1673

Overview

Joseph J. Locascio is affiliated with Harvard University in the United States and has contributed extensively to the field of Medicine, with a focus on Psychiatry and Mental Health, Neurology, Physiology, Cellular and Molecular Neuroscience, and General Health Professions. Their research encompasses areas such as Dementia and Cognitive Impairment, Parkinson's Disease Mechanisms and Treatments, Alzheimer's Disease research and treatments, Health Systems and Economic Evaluations, Neurological Disorders and Treatments, Epilepsy research and treatment, as well as Neuroscience and Neuropharmacology.

Locascio's frequent publication venues include Alzheimer s & Dementia, Neurology, Brain, Innovation in Aging, and Nature Genetics.

  • Alzheimer s & Dementia
  • Neurology
  • Brain
  • Innovation in Aging
  • Nature Genetics

Recent papers authored or co-authored by Locascio highlight research across neuroscience and neurodegenerative diseases. Notable publications include:

  • Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease (2021), Nature Genetics
  • Serum NFL levels predict progression of motor impairment and reduction in putamen dopamine transporter binding ratios in de novo Parkinson's disease: An 8-year longitudinal study (2021), Parkinsonism & Related Disorders
  • The presubiculum links incipient amyloid and tau pathology to memory function in older persons (2020), Neurology
  • The neurophysiology and seizure outcomes of late onset unexplained epilepsy (2020), Clinical Neurophysiology
  • Mitochondrial haplogroups and cognitive progression in Parkinson's disease (2022), Brain

The scientist collaborates frequently with colleagues including Keith A. Johnson, Gad A. Marshall, Michael J Properzi, Reisa A. Sperling, and John H. Growdon.

  • Keith A. Johnson
  • Gad A. Marshall
  • Michael J Properzi
  • Reisa A. Sperling
  • John H. Growdon

Best Publications

  • PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

    Bin Zheng;Zhixiang Liao;Joseph J. Locascio;Kristen A. Lesniak

  • α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

    Brit Mollenhauer;Brit Mollenhauer;Joseph J Locascio;Walter Schulz-Schaeffer;Friederike Sixel-Döring

  • Molecular markers of early Parkinson's disease based on gene expression in blood

    Clemens R. Scherzer;Clemens R. Scherzer;Aron C. Eklund;Lee J. Morse;Zhixiang Liao

  • Imaging amyloid deposition in Lewy body diseases

    S. N. Gomperts;D. M. Rentz;E. Moran;J. A. Becker

  • Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease

    Gad A. Marshall;Gad A. Marshall;Dorene M. Rentz;Dorene M. Rentz;Meghan T. Frey;Joseph J. Locascio

  • Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

    Takahiko Tokuda;Sultan A. Salem;David Allsop;Toshiki Mizuno

  • CLINICAL AND PATHOLOGICAL CORRELATES OF APOLIPOPROTEIN E EPSILON 4 IN ALZHEIMER'S DISEASE

    Gomez-Isla T;West Hl;Rebeck Gw;Harr Sd

  • Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

    Brit Mollenhauer;Valerie Cullen;Ilana Kahn;Bryan Krastins

  • β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

    Shuchi Mittal;Kjetil Bjørnevik;Kjetil Bjørnevik;Doo Soon Im;Adrian Flierl

  • Cognition, reserve, and amyloid deposition in normal aging

    Dorene M Rentz;Joseph J Locascio;Joseph J Locascio;John A Becker;Erin K Moran

  • Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

    Hiroaki Fukumoto;Marsha Tennis;Joseph J. Locascio;Bradley T. Hyman

  • Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease

    Alireza Atri;Lynn W. Shaughnessy;Joseph J. Locascio;John H. Growdon

  • Cognitive test performance in detecting, staging, and tracking Alzheimer's disease

    Joseph J. Locascio;John H. Growdon;Suzanne Corkin

  • Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

    Nancy J. Donovan;Joseph J. Locascio;Gad A. Marshall;Jennifer Gatchel

  • Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.

    Ganqiang Liu;Brendon Boot;Brendon Boot;Joseph J Locascio;Joseph J Locascio;Iris E Jansen;Iris E Jansen

  • Subjective Cognitive Concerns and Neuropsychiatric Predictors of Progression to the Early Clinical Stages of Alzheimer Disease

    Nancy J. Donovan;Rebecca E. Amariglio;Rebecca E. Amariglio;Amy S. Zoller;Rebecca K. Rudel

  • Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.

    Stefanie H. Freeman;Ruth Kandel;Luis Cruz;Anete Rozkalne

  • Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases.

    Stephen N. Gomperts;Joseph J. Locascio;Sara J. Makaretz;Aaron Schultz

  • Reliability of MRI-derived cortical and subcortical morphometric measures: effects of pulse sequence, voxel geometry, and parallel imaging.

    J.S. Wonderlick;D.A. Ziegler;P. Hosseini-Varnamkhasti;J.J. Locascio

  • A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery.

    Steven D Shirk;Steven D Shirk;Meghan B Mitchell;Meghan B Mitchell;Lynn W Shaughnessy;Janet C Sherman

  • Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease.

    J. H. Growdon;J. J. Locascio;S. Corkin;T. Gomez-Isla

  • Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease

    M. C. Irizarry;M. E. Gurol;S. Raju;R. Diaz-Arrastia

Frequent Co-Authors

Reisa A. Sperling
Reisa A. Sperling Brigham and Women's Hospital
Dorene M. Rentz
Dorene M. Rentz Harvard Medical School
Gad A. Marshall
Gad A. Marshall Brigham and Women's Hospital
Bradley T. Hyman
Bradley T. Hyman Harvard University
Rebecca Amariglio
Rebecca Amariglio Harvard Medical School
Bradford C. Dickerson
Bradford C. Dickerson Harvard Medical School
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases
Joseph T. Giacino
Joseph T. Giacino Massachusetts General Hospital
Aaron P. Schultz
Aaron P. Schultz Harvard University

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