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Thomas B. Issekutz

Thomas B. Issekutz

D-Index & Metrics

Immunology

D-Index
58
Citations
9884
World Ranking
3558
National Ranking
92

Overview

Thomas B. Issekutz is affiliated with Dalhousie University in Canada and has contributed extensively to research within the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields including Immunology, Genetics, Hematology, Rheumatology, and Oncology.

The scientist's research covers a diverse range of main topics such as Immunodeficiency and Autoimmune Disorders, Immune Cell Function and Interaction, Blood disorders and treatments, Autoimmune and Inflammatory Disorders Research, Blood groups and transfusion, Rheumatoid Arthritis Research and Therapies, and Systemic Lupus Erythematosus Research.

Frequent coauthors collaborating with Thomas B. Issekutz include Beáta Dérfalvi, Sarah M. McAlpine, Drew Slauenwhite, Anikó Malik, and Jean S. Marshall.

Common venues for publication include Frontiers in Immunology, Clinical Immunology, Allergy Asthma and Clinical Immunology, Arthritis & Rheumatology, and The Journal of Rheumatology.

Key recent papers authored or coauthored by Thomas B. Issekutz include:

  • Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins (2022) published in Allergy Asthma and Clinical Immunology
  • High Dose Intravenous IgG Therapy Modulates Multiple NK Cell and T Cell Functions in Patients With Immune Dysregulation (2021) published in Frontiers in Immunology
  • Association of a Type 2-Polarized T Cell Phenotype With Methotrexate Nonresponse in Patients With Rheumatoid Arthritis (2020) published in Arthritis & Rheumatology
  • Clinical exome sequencing data from patients with inborn errors of immunity: Cohort level diagnostic yield and the benefit of systematic reanalysis (2024) published in Clinical Immunology
  • Differentially Expressed Inflammation-Regulating MicroRNAs in Oligoarticular Juvenile Idiopathic Arthritis (2022) published in The Journal of Rheumatology

Best Publications

  • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

    Ingo Bartholomäus;Naoto Kawakami;Francesca Odoardi;Christian Schläger

  • Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

    Christian Schläger;Henrike Körner;Martin Krueger;Stefano Vidoli

  • Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody. A likely role for VLA-4 in vivo.

    T B Issekutz

  • Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.

    Asbjørg Stray-Pedersen;Hanne Sørmo Sorte;Pubudu Samarakoon;Tomasz Gambin;Tomasz Gambin

  • Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1

    Brent Johnston;Alan R. Burns;Makoto Suematsu;Thomas B. Issekutz

  • Requirements for leukocyte adhesion molecules in nephrotoxic nephritis.

    M S Mulligan;K J Johnson;rd R F Todd;T B Issekutz

  • Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-gamma.

    T B Issekutz;J M Stoltz;P vd Meide

  • Role of CD11a and CD11b in ischemic acute renal failure in rats

    H. Rabb;C. C. Mendiola;J. Dietz;S. R. Saba

  • Role of β1 β2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes

    M S Mulligan;G P Wilson;R F Todd;C W Smith

  • Unexpected role of surface transglutaminase type II in celiac disease

    Luigi Maiuri;Carolina Ciacci;Ida Ricciardelli;Loredana Vacca

  • The in vivo quantitation and kinetics of monocyte migration into acute inflammatory tissue.

    Issekutz Tb;Issekutz Ac;Movat Hz

  • In vivo blood monocyte migration to acute inflammatory reactions, IL-1 alpha, TNF-alpha, IFN-gamma, and C5a utilizes LFA-1, Mac-1, and VLA-4. The relative importance of each integrin.

    T B Issekutz

  • Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.

    Sarah M Burke;Thomas B Issekutz;Karkada Mohan;Patrick W K Lee

  • Rat Blood Neutrophils Express Very Late Antigen 4 and it Mediates Migration to Arthritic Joint and Dermal Inflammation

    Thomas B. Issekutz;Masayuki Miyasaka;Andrew C. Issekutz

  • The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo.

    Brent Johnston;Thomas B. Issekutz;Paul Kubes

  • L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration

    Ziqiang Ding;Thomas B. Issekutz;Gregory P. Downey;Thomas K. Waddell

  • The alpha 4 beta 1 (very late antigen (VLA)-4, CD49d/CD29) and alpha 5 beta 1 (VLA-5, CD49e/CD29) integrins mediate beta 2 (CD11/CD18) integrin-independent neutrophil recruitment to endotoxin-induced lung inflammation.

    J A Burns;T B Issekutz;H Yagita;A C Issekutz

  • The Use of Immunoglobulin Therapy for Patients With Primary Immune Deficiency: An Evidence-Based Practice Guideline

    Nadine Shehata;Valerie Palda;Tom Bowen;Elie Haddad

  • Blockade of Chemokine Receptor CXCR3 Inhibits T Cell Recruitment to Inflamed Joints and Decreases the Severity of Adjuvant Arthritis

    Karkada Mohan;Thomas B. Issekutz

  • Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat.

    T B Issekutz;A Wykretowicz

  • Role of leukocyte adhesion molecules in lung and dermal vascular injury after thermal trauma of skin.

    M. S. Mulligan;G. O. Till;C. W. Smith;D. C. Anderson

Frequent Co-Authors

Andrew C. Issekutz
Andrew C. Issekutz Dalhousie University
Jean S. Marshall
Jean S. Marshall Dalhousie University
Masayuki Miyasaka
Masayuki Miyasaka Osaka University
Paul Kubes
Paul Kubes University of Calgary
Stuart E. Turvey
Stuart E. Turvey University of British Columbia
Elie Haddad
Elie Haddad University of Montreal
Stefan Feske
Stefan Feske New York University
Takuya Tamatani
Takuya Tamatani Japan Tobacco (United States)
Bertrand Boisson
Bertrand Boisson Rockefeller University
Capucine Picard
Capucine Picard Université Paris Cité

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