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Molecular Biology

D-Index
68
Citations
16080
World Ranking
1520
National Ranking
119

Overview

Rachael Natrajan is affiliated with the Institute of Cancer Research in the United Kingdom and has contributed extensively to research in cancer biology and related fields. Their work primarily spans biochemistry, genetics, molecular biology, and medicine, with a strong focus on oncology and cancer research.

Their subfields of study include:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Pathology and Forensic Medicine
  • Pulmonary and Respiratory Medicine

Natrajan's main research topics cover an array of cancer-related areas:

  • Chromatin Remodeling and Cancer
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Breast Cancer Treatment Studies
  • Cancer Mechanisms and Therapy
  • Ovarian Cancer Diagnosis and Treatment
  • Advanced Breast Cancer Therapies

Their recent publications include:

  • Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes, 2020, Cancer Discovery
  • Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors, 2020, Journal of Clinical Oncology
  • ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response, 2020, Nature Genetics
  • ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI), 2021, International Journal of Gynecological Cancer
  • Subclonal heterogeneity and evolution in breast cancer, 2021, npj Breast Cancer

Frequent co-authors who have collaborated with Natrajan include:

  • Syed Haider
  • Christopher J. Lord
  • John Alexander
  • Naomi Guppy
  • Ioanna Mavrommati

Natrajan publishes consistently in several scientific venues, with the most frequent being:

  • Cancer Research
  • Nature Genetics
  • Cancers
  • Annals of Oncology
  • npj Breast Cancer

Best Publications

  • Resistance to therapy caused by intragenic deletion in BRCA2

    Stacey L. Edwards;Rachel Brough;Christopher J. Lord;Rachael Natrajan

  • Complex landscapes of somatic rearrangement in human breast cancer genomes.

    Philip J. Stephens;David J. Mcbride;Meng-lay Lin;Ignacio Varela

  • BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

    Gemma Molyneux;Felipe C. Geyer;Fiona-Ann Magnay;Afshan McCarthy

  • Breast cancer molecular profiling with single sample predictors: a retrospective analysis

    Britta Weigelt;Alan Mackay;Roger A'hern;Rachael Natrajan

  • Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.

    N Turner;M B Lambros;H M Horlings;A Pearson

  • β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

    Felipe C Geyer;Magali Lacroix-Triki;Kay Savage;Monica Arnedos

  • Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

    Dan R. Robinson;Shanker Kalyana-Sundaram;Shanker Kalyana-Sundaram;Yi Mi Wu;Sunita Shankar

  • PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

    Konstantin J. Dedes;Daniel Wetterskog;Ana M. Mendes-Pereira;Rachael Natrajan

  • Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

    Munir R. Tanas;Andrea Sboner;Andre M. Oliveira;Michele R. Erickson-Johnson

  • Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

    Illirjana Bajrami;Jessica R. Frankum;Asha Konde;Rowan E. Miller

  • The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type.

    Britta Weigelt;Felipe C Geyer;Rachael Natrajan;Maria A Lopez-Garcia;Maria A Lopez-Garcia

  • Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C

    Nicola H. Dryden;Laura R. Broome;Frank Dudbridge;Nichola Johnson

  • Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

    Matthew Clarke;Alan Mackay;Britta Ismer;Britta Ismer;Jessica Chiara Pickles

  • Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.

    Felipe C Geyer;Britta Weigelt;Rachael Natrajan;Maryou B K Lambros

  • SF3B1 mutations constitute a novel therapeutic target in breast cancer

    Sarah L. Maguire;Andri Leonidou;Patty Wai;Caterina Marchiò;Caterina Marchiò

  • Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type

    Magali Lacroix-Triki;Paula H Suarez;Alan MacKay;Maryou B Lambros

  • Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection

    Lucia Hernandez;Paul M Wilkerson;Maryou B Lambros;Adriana Campion-Flora

  • Tiling path genomic profiling of grade 3 invasive ductal breast cancers.

    Rachael Natrajan;Maryou B. Lambros;Socorro María Rodríguez-Pinilla;Gema Moreno-Bueno

  • Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers†

    Daniel Wetterskog;Maria Angeles Lopez-Garcia;Maria Angeles Lopez-Garcia;Maryou B Lambros;Roger A'Hern

  • FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo

    Rachel Sharpe;Alex Pearson;Maria T. Herrera-Abreu;Damian A. Johnson

Frequent Co-Authors

Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
Alan Ashworth
Alan Ashworth University of California, San Francisco
Alan Mackay
Alan Mackay Institute of Cancer Research
Christopher J. Lord
Christopher J. Lord Institute of Cancer Research
Chris Jones
Chris Jones Institute of Cancer Research
Anne Vincent-Salomon
Anne Vincent-Salomon Institute Curie
Charlotte K.Y. Ng
Charlotte K.Y. Ng Humanitas University
Andrew Tutt
Andrew Tutt Institute of Cancer Research
Kathy Pritchard-Jones
Kathy Pritchard-Jones University College London
Salvatore Piscuoglio
Salvatore Piscuoglio Humanitas University

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