World's Best Scientists 2026 revealed!
Rupert Handgretinger

Rupert Handgretinger

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
40792
World Ranking
1354
National Ranking
85

Medicine

D-Index
102
Citations
41173
World Ranking
7618
National Ranking
432

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2015 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Gynaecology and Paediatrics

Overview

Rupert Handgretinger is affiliated with the University of Tübingen in Germany. Their research focuses primarily on Medicine, with significant contributions across subfields such as Oncology, Hematology, Immunology, Genetics, and Molecular Biology.

The scientist's main areas of work include:

  • CAR-T cell therapy research
  • Hematopoietic Stem Cell Transplantation
  • Immune Cell Function and Interaction
  • Neuroblastoma Research and Treatments
  • Acute Lymphoblastic Leukemia research
  • Virus-based gene therapy research
  • Childhood Cancer Survivors' Quality of Life

Rupert Handgretinger has contributed to a range of notable papers, including:

  • CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia, 2020, New England Journal of Medicine
  • Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer, 2021, Nature Communications
  • Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany, 2021, JAMA Pediatrics
  • Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia, 2024, New England Journal of Medicine
  • Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study, 2020, Blood Cancer Journal

Frequent collaborators of Rupert Handgretinger include:

  • Peter Lang
  • Michaela Döring
  • Christian Seitz
  • Markus Mezger
  • Martin Ebinger

Their publications are often featured in prominent journals such as:

  • Blood
  • Bone Marrow Transplantation
  • Journal of Cancer Research and Clinical Oncology
  • Frontiers in Immunology
  • Transplantation and Cellular Therapy

Rupert Handgretinger's research spans medicine with a multidisciplinary approach, integrating genetic, immunological, and oncological perspectives, particularly focusing on therapies involving immune system manipulation and cellular transplantation.

In 2015, they were recognized by the German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften for work related to Gynaecology and Paediatrics.

Best Publications

  • Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

    Leonard D. Shultz;Bonnie L. Lyons;Lisa M. Burzenski;Bruce Gott

  • CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

    Haydar Frangoul;David Altshuler;M. Domenica Cappellini;Yi-Shan Chen

  • Truncating Mutations of hSNF5/INI1 in Aggressive Paediatric Cancer

    Isabella Versteege;Nicolas Sévenet;Julian Lange;Marie-Françoise Rousseau-Merck

  • Treating childhood acute lymphoblastic leukemia without cranial irradiation.

    Ching Hon Pui;Dario Campana;Deqing Pei;W. Paul Bowman

  • Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

    Michael S D Kormann;Günther Hasenpusch;Manish K Aneja;Gabriela Nica

  • T-helper-1-cell cytokines drive cancer into senescence

    Heidi Braumüller;Thomas Wieder;Ellen Brenner;Sonja Aßmann

  • Determinants of Antileukemia Effects of Allogeneic NK Cells

    Wing Leung;Rekha Iyengar;Victoria Turner;Peter Lang

  • Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers.

    Nicolas Sévenet;Eammon Sheridan;Daniel Amram;Pascale Schneider

  • Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation.

    Tobias Feuchtinger;Kathrin Opherk;Wolfgang A. Bethge;Max S. Topp

  • Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

    Arend von Stackelberg;Franco Locatelli;Gerhard Zugmaier;Rupert Handgretinger

  • HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

    Alice Bertaina;Pietro Merli;Sergio Rutella;Sergio Rutella;Daria Pagliara

  • Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation

    Tobias Feuchtinger;Susanne Matthes-Martin;Celine Richard;Thomas Lion

  • Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study Group

    Peter Bader;Hermann Kreyenberg;Günter H.R. Henze;Cornelia Eckert

  • Megadose transplantation of purified peripheral blood CD34 + progenitor cells from HLA-mismatched parental donors in children

    R Handgretinger;T Klingebiel;P Lang;P Lang;M Schumm;M Schumm

  • Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

    Christina Holzwarth;Martin Vaegler;Friederike Gieseke;Stefan M Pfister

  • A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch14.18 in patients with neuroblastoma

    R. Handgretinger;K. Anderson;P. Lang;R. Dopfer

  • Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?

    Peter Bader;Hermann Kreyenberg;Walter Hoelle;Gregor Dueckers

  • Pure red cell aplasia

    Paul Fisch;Rupert Handgretinger;Hans-Eckart Schaefer

  • Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1–Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation

    Vanya Icheva;Simone Kayser;Daniel Wolff;Sebastian Tuve

  • Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2rγnull Mice Engrafted with Mobilized Human Hematopoietic Stem Cells.

    Leonard Shultz;Bonnie L. Lyons;Lisa M. Burzenski;Bruce Gott

Frequent Co-Authors

Peter Lang
Peter Lang University of Bern
Dietrich Niethammer
Dietrich Niethammer University of Tübingen
Peter Bader
Peter Bader Goethe University Frankfurt
Thomas Klingebiel
Thomas Klingebiel Goethe University Frankfurt
Lothar Kanz
Lothar Kanz University of Tübingen
Dominik Hartl
Dominik Hartl Novartis (Switzerland)
Hans-Georg Rammensee
Hans-Georg Rammensee University of Tübingen
Martin Schrappe
Martin Schrappe Kiel University
Arndt Borkhardt
Arndt Borkhardt Heinrich Heine University Düsseldorf
Stefan Stevanovic
Stefan Stevanovic University of Tübingen

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