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Genetics

D-Index
80
Citations
54242
World Ranking
1546
National Ranking
719

Overview

Christoph Lengauer is affiliated with Johns Hopkins University in the United States. Their research spans several fields, primarily focusing on biochemistry, genetics, and molecular biology, with additional work in medicine.

The main subfields of study include molecular biology, cancer research, radiology, nuclear medicine and imaging, rheumatology, and nephrology. The scientist's work covers a range of topics such as cancer genomics and diagnostics, 14-3-3 protein interactions, radiomics and machine learning in medical imaging, medical imaging techniques and applications, heterotopic ossification and related conditions, parathyroid disorders and treatments, and medical imaging and pathology studies.

Recent publications by Christoph Lengauer feature diverse topics and venues:

  • Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention, 2020, Science
  • An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva, 2024, Science Translational Medicine
  • Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma, 2022, Gastro Hep Advances
  • Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Author Correction: 14-3-3σ is required to prevent mitotic catastrophe after DNA damage, 2023, Nature

The scientist frequently collaborates with several coauthors who have partnered on at least three publications each, including Timothy P. LaBranche, Riadh Lobbardi, Michael Palmer, Marion Dorsch, and Timothy Guzi.

Publication venues prominently associated with Christoph Lengauer's work include:

  • Science
  • Science Translational Medicine
  • Gastro Hep Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature

Best Publications

  • Genetic instabilities in human cancers

    Christoph Lengauer;Kenneth W. Kinzler;Bert Vogelstein

  • Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage

    Fred Bunz;A. Dutriaux;C. Lengauer;T. Waldman

  • Genetic instability in colorectal cancers

    C. Lengauer;K. W. Kinzler;B. Vogelstein

  • Genes expressed in human tumor endothelium

    Brad St. Croix;Carlo Rago;Carlo Rago;Victor Velculescu;Giovanni Traverso

  • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

    Shih Min A Huang;Yuji M. Mishina;Shanming Liu;Atwood Cheung

  • Mutations of mitotic checkpoint genes in human cancers

    Daniel P. Cahill;Christoph Lengauer;Jian Yu;Gregory J. Riggins

  • 14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression

    Heiko Hermeking;Christoph Lengauer;Kornelia Polyak;Tong Chuan He

  • DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.

    Ina Rhee;Kurtis E. Bachman;Ben Ho Park;Kam Wing Jair

  • Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.

    Harith Rajagopalan;Alberto Bardelli;Christoph Lengauer;Kenneth W. Kinzler

  • Disruption of p53 in human cancer cells alters the responses to therapeutic agents

    Fred Bunz;Paul M. Hwang;Chris Torrance;Chris Torrance;Todd Waldman

  • 14-3-3σ is required to prevent mitotic catastrophe after DNA damage

    Timothy A. Chan;Heiko Hermeking;Christoph Lengauer;Kenneth W. Kinzler

  • Mutant PIK3CA promotes cell growth and invasion of human cancer cells

    Yardena Samuels;Luis A. Diaz;Oleg Schmidt-Kittler;Jordan M. Cummins

  • Somatic mutations of the mitochondrial genome in human colorectal tumours

    Kornelia Polyak;Kornelia Polyak;Yunbo Li;Hong Zhu;Christoph Lengauer

  • Aneuploidy and cancer

    Harith Rajagopalan;Christoph Lengauer

  • Genetic instability and darwinian selection in tumours

    Daniel P Cahill;Kenneth W Kinzler;Bert Vogelstein;Christoph Lengauer

  • Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.

    Jihye Yun;Carlo Rago;Ian Cheong;Ray Pagliarini;Ray Pagliarini

  • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

    Todd Waldman;Christoph Lengauer;Kenneth W. Kinzler;Bert Vogelstein

  • A Phosphatase Associated with Metastasis of Colorectal Cancer

    Saurabh Saha;Alberto Bardelli;Phillip Buckhaults;Victor E. Velculescu

  • Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.

    Sam Thiagalingam;Christoph Lengauer;Frederick S. Leach;Mieke Schutte

  • Inactivation of hCDC4 can cause chromosomal instability

    Harith Rajagopalan;Prasad V. Jallepalli;Prasad V. Jallepalli;Carlo Rago;Victor E. Velculescu

Frequent Co-Authors

Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Victor E. Velculescu
Victor E. Velculescu Johns Hopkins University School of Medicine
Alberto Bardelli
Alberto Bardelli University of Turin
Sanford D. Markowitz
Sanford D. Markowitz Case Western Reserve University
James K V Willson
James K V Willson The University of Texas at Dallas
Luis A. Diaz
Luis A. Diaz Memorial Sloan Kettering Cancer Center
Martin A. Nowak
Martin A. Nowak Harvard University
Stephen B. Baylin
Stephen B. Baylin Johns Hopkins University
Tian Li Wang
Tian Li Wang Johns Hopkins University

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