World's Best Scientists 2026 revealed!

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Immunology

D-Index
100
Citations
36097
World Ranking
727
National Ranking
415

Medicine

D-Index
100
Citations
36105
World Ranking
8289
National Ranking
4289

Research.com Recognitions

  • 2015 - Presidential Award, Clinical Immunology Society
  • 2009 - Distinguished Service Award, Clinical Immunology Society

Overview

Thomas A. Fleisher is affiliated with the National Institutes of Health in the United States. The scientist's research intersects multiple disciplines within medicine and immunology, focusing extensively on immunodeficiency and autoimmune disorders as well as blood-related diseases and hormone regulation.

The main fields of study include:

  • Medicine
  • Immunology and Microbiology

Specific subfields of study include:

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health
  • Hematology
  • Genetics

The principal topics explored in their work are:

  • Immunodeficiency and Autoimmune Disorders
  • Acute Lymphoblastic Leukemia research
  • Acute Myeloid Leukemia Research
  • Blood disorders and treatments
  • Cystic Fibrosis Research Advances
  • Adrenal Hormones and Disorders
  • Cytokine Signaling Pathways and Interactions

Recent publications authored or co-authored include:

  • "Germline IKAROS dimerization haploinsufficiency causes hematologic cytopenias and malignancies," 2020, published in Blood
  • "Diagnostic tests for primary immunodeficiency disorders: Classic and genetic testing," 2024, published in Allergy and Asthma Proceedings
  • "Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21," 2021, published in Journal of Allergy and Clinical Immunology
  • "An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome," 2020, published in UNC Libraries
  • "Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations," 2025, published in Blood Advances

Frequent co-authors collaborating with Thomas A. Fleisher include:

  • Sergio D. Rosenzweig
  • Hye Sun Kuehn
  • Julie E. Niemela
  • Jennifer Stoddard
  • Kaan Boztuğ

Their contributions have been disseminated through several publication venues, notably:

  • Blood
  • Allergy and Asthma Proceedings
  • Journal of Allergy and Clinical Immunology
  • UNC Libraries
  • Blood Advances

Thomas A. Fleisher has received recognition in the form of awards such as the Presidential Award from the Clinical Immunology Society in 2015 and the Distinguished Service Award from the same society in 2009.

Best Publications

  • T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years

    R. Michael Blaese;Kenneth W. Culver;A. Dusty Miller;Charles S. Carter

  • Activated STING in a Vascular and Pulmonary Syndrome

    Y. Liu;A.A. Jesus;B. Marrero;D. Yang

  • Age, thymopoiesis, and CD4+ t-lymphocyte regeneration after intensive chemotherapy

    Crystal L. Mackall;Thomas A. Fleisher;Margaret R. Brown;Mary P. Andrich

  • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

    Hye Sun Kuehn;Weiming Ouyang;Bernice Lo;Elissa K. Deenick;Elissa K. Deenick

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

    Kevin C. Conlon;Enrico Lugli;Hugh C. Welles;Hugh C. Welles;Steven A. Rosenberg

  • Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

    Sung Yun Pai;Brent R. Logan;Linda M. Griffith;Rebecca H. Buckley

  • An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

    Scott W. Canna;Adriana Almeida de Jesus;Sushanth Gouni;Stephen R. Brooks

  • Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

    Carrie L Lucas;Hye Sun Kuehn;Fang Zhao;Julie E Niemela

  • Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

    Gabor G. Illei;Yuko Shirota;Cheryl H. Yarboro;Jimmy Daruwalla

  • The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

    Stephen E. Straus;Elaine S. Jaffe;Jennifer M. Puck;Janet K. Dale

  • Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes.

    S.J. Vowells;S. Sekhsaria;H.L. Malech;M. Shalit

  • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

    Claude Sportès;Frances T. Hakim;Sarfraz A. Memon;Hua Zhang

  • Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.

    Joao B. Oliveira;Jack J. Bleesing;Umberto Dianzani;Thomas A. Fleisher

  • Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte Apoptosis

    Michael C. Sneller;Jin Wang;Janet K. Dale;Warren Strober

  • A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

    T Uchiyama;D L Nelson;T A Fleisher;T A Waldmann

  • Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

    Crystal L. Mackall;Thomas A. Fleisher;Thomas A. Fleisher;Margaret R. Brown;Margaret R. Brown;Mary P. Andrich;Mary P. Andrich

  • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

    Hua Zhang;Kevin S Chua;Martin Guimond;Veena Kapoor

  • Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors

    Ilia J. Elenkov;Elizabeth Webster;Dimitris A. Papanicolaou;Thomas A. Fleisher

  • Lymphocyte depletion during treatment with intensive chemotherapy for cancer.

    Crystal L. Mackall;Thomas A. Fleisher;Margaret R. Brown;Ian T. Magrath

Frequent Co-Authors

Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco
Thomas A. Waldmann
Thomas A. Waldmann National Institutes of Health
Sergio D. Rosenzweig
Sergio D. Rosenzweig National Institutes of Health
Stefania Pittaluga
Stefania Pittaluga National Institutes of Health
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health
Sharon E. Straus
Sharon E. Straus University of Toronto
Harry L. Malech
Harry L. Malech National Institutes of Health
William T. Shearer
William T. Shearer Baylor College of Medicine
Jack J. Bleesing
Jack J. Bleesing Cincinnati Children's Hospital Medical Center
Rebecca H. Buckley
Rebecca H. Buckley Duke University

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