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Neuroscience

D-Index
56
Citations
10253
World Ranking
4549
National Ranking
113

Best Publications

  • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

    Fabrizio Gasparini;Kurt Lingenhöhl;Natacha Stoehr;Peter J Flor

  • The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors

    Adriana Pagano;Adriana Pagano;Doris Rüegg;Stephane Litschig;Natacha Stoehr

  • C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

    Adriana Pagano;Giorgio Rovelli;Johannes Mosbacher;Tania Lohmann;Tania Lohmann

  • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.

    Ewa Tatarczyńska;Aleksandra Kłodzińska;Ewa Chojnacka-Wójcik;Agnieszka Pałucha

  • Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

    Edward J. Wild;Roberto Boggio;Douglas Langbehn;Nicola Robertson

  • mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

    K Walker;A Reeve;M Bowes;J Winter

  • Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

    Thierry Galvez;Marie-Laure Parmentier;Cécile Joly;Barbara Malitschek

  • Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

    Gilles Sansig;Trevor J. Bushell;Vernon R. J. Clarke;Andrei Rozov

  • (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

    M. Maj;V. Bruno;Z. Dragic;R. Yamamoto

  • Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders.

    Will P.J.M. Spooren;Fabrizio Gasparini;Thomas E. Salt;Rainer Kuhn

  • Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

    Kumlesh K. Dev;Florian Mullershausen;Henri Mattes;Rainer R. Kuhn

  • Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

    Will P.J.M Spooren;Philippe Schoeffter;Fabrizio Gasparini;Rainer Kuhn

  • Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

    Fabrizio Gasparini;Rainer Kuhn;Jean-Philippe Pin

  • The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

    Jesus Gomeza;Cecile Joly;Rainer Kuhn;Thomas Knöpfel

  • Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.

    V. Bruno;A. Copani;T. Knöpfel;R. Kuhn

  • Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

    K Walker;M Bowes;M Panesar;A Davis

  • The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

    Brigitte Schulz;Markus Fendt;Fabrizio Gasparini;Kurt Lingenhöhl

  • Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

    G. Casabona;T. Knopfel;R. Kuhn;F. Gasparini

  • Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

    Andreas Weiss;Ulrike Träger;Edward J. Wild;Stephan Grueninger

  • The Neuroprotective Activity of Group-II Metabotropic Glutamate Receptors Requires New Protein Synthesis and Involves a Glial–Neuronal Signaling

    Valeria Bruno;Francesc X. Sureda;Marianna Storto;Giacomo Casabona

  • Compartmental Localization of a Metabotropic Glutamate Receptor (mGluR7): Two Different Active Sites at a Retinal Synapse

    Johann Helmut Brandstätter;Peter Koulen;Rainer Kuhn;Herman van der Putten

Frequent Co-Authors

Thomas Knöpfel
Thomas Knöpfel Hong Kong Baptist University
Pedro Grandes
Pedro Grandes University of the Basque Country
Laszlo Urban
Laszlo Urban Novartis (Switzerland)
Yves-Alain Barde
Yves-Alain Barde Cardiff University
David R. Hampson
David R. Hampson University of Toronto
Herman van der Putten
Herman van der Putten Novartis (Switzerland)
Christian E. Elger
Christian E. Elger University Hospital Bonn
Thomas E. Salt
Thomas E. Salt University College London
Anne B. Young
Anne B. Young Harvard University
Gillian P. Bates
Gillian P. Bates University College London

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