Rainer Kuhn

Best Publications

• 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

  Fabrizio Gasparini;Kurt Lingenhöhl;Natacha Stoehr;Peter J Flor

  859
  Citations

• The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors

  Adriana Pagano;Adriana Pagano;Doris Rüegg;Stephane Litschig;Natacha Stoehr

  393
  Citations

• C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

  Adriana Pagano;Giorgio Rovelli;Johannes Mosbacher;Tania Lohmann;Tania Lohmann

  377
  Citations

• Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.

  Ewa Tatarczyńska;Aleksandra Kłodzińska;Ewa Chojnacka-Wójcik;Agnieszka Pałucha

  368
  Citations

• Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

  Edward J. Wild;Roberto Boggio;Douglas Langbehn;Nicola Robertson

  305
  Citations

• mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

  K Walker;A Reeve;M Bowes;J Winter

  269
  Citations

• Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

  Thierry Galvez;Marie-Laure Parmentier;Cécile Joly;Barbara Malitschek

  253
  Citations

• Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

  Gilles Sansig;Trevor J. Bushell;Vernon R. J. Clarke;Andrei Rozov

  242
  Citations

• (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

  M. Maj;V. Bruno;Z. Dragic;R. Yamamoto

  241
  Citations

• Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders.

  Will P.J.M. Spooren;Fabrizio Gasparini;Thomas E. Salt;Rainer Kuhn

  236
  Citations

• Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

  Kumlesh K. Dev;Florian Mullershausen;Henri Mattes;Rainer R. Kuhn

  234
  Citations

• Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

  Will P.J.M Spooren;Philippe Schoeffter;Fabrizio Gasparini;Rainer Kuhn

  223
  Citations

• Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

  Fabrizio Gasparini;Rainer Kuhn;Jean-Philippe Pin

  217
  Citations

• The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins

  Jesus Gomeza;Cecile Joly;Rainer Kuhn;Thomas Knöpfel

  213
  Citations

• Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.

  V. Bruno;A. Copani;T. Knöpfel;R. Kuhn

  208
  Citations

• Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

  K Walker;M Bowes;M Panesar;A Davis

  205
  Citations

• The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

  Brigitte Schulz;Markus Fendt;Fabrizio Gasparini;Kurt Lingenhöhl

  184
  Citations

• Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

  G. Casabona;T. Knopfel;R. Kuhn;F. Gasparini

  176
  Citations

• Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

  Andreas Weiss;Ulrike Träger;Edward J. Wild;Stephan Grueninger

  176
  Citations

• The Neuroprotective Activity of Group-II Metabotropic Glutamate Receptors Requires New Protein Synthesis and Involves a Glial–Neuronal Signaling

  Valeria Bruno;Francesc X. Sureda;Marianna Storto;Giacomo Casabona

  175
  Citations

• Compartmental Localization of a Metabotropic Glutamate Receptor (mGluR7): Two Different Active Sites at a Retinal Synapse

  Johann Helmut Brandstätter;Peter Koulen;Rainer Kuhn;Herman van der Putten

  172
  Citations