World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
17700
World Ranking
11176
National Ranking
4839

Overview

Yuval Itan is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in medicine as well. Within these broader fields, their work concentrates on genetics, molecular biology, immunology, physiology, and cardiology and cardiovascular medicine.

The scientist has published extensively on topics including genomics and rare diseases, immunodeficiency and autoimmune disorders, genetic associations and epidemiology, adipose tissue and metabolism, inflammatory bowel disease, bioinformatics and genomic networks, and RNA modifications and cancer.

Yuval Itan has contributed to journals and publication venues such as Gastroenterology, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Zenodo (CERN European Organization for Nuclear Research), and the Journal of Clinical Investigation.

  • Recent papers include:
  • Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities (2021, Nature Metabolism)
  • TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons (2021, Journal of Clinical Investigation)
  • Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target (2021, Gastroenterology)
  • Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort (2020, Gastroenterology)
  • The genetic structure of the Turkish population reveals high levels of variation and admixture (2021, Proceedings of the National Academy of Sciences)

Frequent co-authors collaborating with Yuval Itan include Meltem Ece Kars, D.N. Cooper, Peter D. Stenson, David Stein, and Çiğdem Sevim Bayrak.

Best Publications

  • Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

    Luyan Liu;Satoshi Okada;Xiao Fei Kong;Alexandra Y. Kreins

  • Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants.

    Aziz Belkadi;Alexandre Bolze;Yuval Itan;Aurélie Cobat;Aurélie Cobat

  • The Origins of Lactase Persistence in Europe

    Yuval Itan;Adam Powell;Mark A. Beaumont;Joachim Burger

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

    Xianqin Zhang;Dusan Bogunovic;Béatrice Payelle-Brogard;Véronique Francois-Newton

  • Lactose digestion and the evolutionary genetics of lactase persistence

    Catherine J. E. Ingram;Charlotte A. Mulcare;Yuval Itan;Mark G. Thomas

  • Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

    Michael J. Ciancanelli;Sarah X.L. Huang;Priya Luthra;Hannah Garner

  • Evolution of lactase persistence: an example of human niche construction

    Pascale Gerbault;Anke Liebert;Yuval Itan;Adam Powell

  • Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

    Satoshi Okada;Satoshi Okada;Janet G Markle;Elissa K Deenick;Elissa K Deenick;Federico Mele

  • A worldwide correlation of lactase persistence phenotype and genotypes

    Yuval Itan;Bryony L Jones;Catherine J E Ingram;Dallas M Swallow

  • Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

    Eric M Scott;Anason Halees;Yuval Itan;Emily G Spencer;Emily G Spencer;Emily G Spencer

  • Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

    Alexandra Y. Kreins;Alexandra Y. Kreins;Michael J. Ciancanelli;Satoshi Okada;Xiao Fei Kong

  • The mutation significance cutoff: gene-level thresholds for variant predictions

    Yuval Itan;Lei Shang;Bertrand Boisson;Bertrand Boisson;Michael J Ciancanelli

  • Modeling recent human evolution in mice by expression of a selected EDAR variant

    Yana George Kamberov;Sijia Wang;Sijia Wang;Jingze Tan;Pascale Gerbault

  • The human gene damage index as a gene-level approach to prioritizing exome variants

    Yuval Itan;Lei Shang;Bertrand Boisson;Etienne Patin;Etienne Patin

  • Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency

    Patrick Maffucci;Charles A. Filion;Bertrand Boisson;Bertrand Boisson;Bertrand Boisson;Yuval Itan

  • Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

    Bertrand Boisson;Emmanuel Laplantine;Kerry Dobbs;Aurélie Cobat

  • Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.

    Matthieu Deschamps;Guillaume Laval;Maud Fagny;Maud Fagny;Maud Fagny;Yuval Itan

  • Loss of B Cells in Patients with Heterozygous Mutations in IKAROS

    Hye Sun Kuehn;Bertrand Boisson;Charlotte Cunningham-Rundles;Janine Reichenbach

  • Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

    Yun Ling;Yun Ling;Sophie Cypowyj;Caner Aytekin;Miguel Galicchio

Frequent Co-Authors

Laurent Abel
Laurent Abel Université Paris Cité
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Bertrand Boisson
Bertrand Boisson Rockefeller University
Stéphanie Boisson-Dupuis
Stéphanie Boisson-Dupuis Université Paris Cité
Shen-Ying Zhang
Shen-Ying Zhang Rockefeller University
Jacinta Bustamante
Jacinta Bustamante Rockefeller University
Aurélie Cobat
Aurélie Cobat Grenoble Alpes University
Lluis Quintana-Murci
Lluis Quintana-Murci Institut Pasteur
Capucine Picard
Capucine Picard Université Paris Cité

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