World's Best Scientists 2026 revealed!

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Microbiology

D-Index
45
Citations
19674
World Ranking
4947
National Ranking
1916

Overview

Amy C. Sims is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple fields with a strong focus on Physics and Astronomy as well as Earth and Planetary Sciences. Within these domains, their work also extends to subfields such as Astronomy and Astrophysics, Oceanography, Environmental Chemistry, Geophysics, and Infectious Diseases.

The scientist has contributed to research across several main topics, including:

  • Geophysics and Gravity Measurements
  • Ionosphere and magnetosphere dynamics
  • Solar and Space Plasma Dynamics
  • Methane Hydrates and Related Phenomena
  • Earthquake Detection and Analysis
  • SARS-CoV-2 and COVID-19 Research
  • Animal Virus Infections Studies

Some of the recent papers associated with Amy C. Sims cover a range of virology and infectious disease topics, reflecting an interdisciplinary approach bridging biological and physical sciences. Notable publications include:

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV, 2020, Nature Communications
  • An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice, 2020, Science Translational Medicine
  • Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection, 2020, Proceedings of the National Academy of Sciences
  • Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking, 2020, UNC Libraries
  • Hypergraph models of biological networks to identify genes critical to pathogenic viral response, 2021, BMC Bioinformatics

The scientist frequently collaborates with several researchers, indicating active participation in collaborative research networks. Frequent co-authors include Song Feng, Marina Gritsenko, Matthew Gaffrey, Mowei Zhou, and Pavlo Bohutskyi.

Major publication venues for this researcher include OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) with a very high output, UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, and the Journal of Proteome Research.

Best Publications

  • Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

    Mingxun Wang;Jeremy J Carver;Vanessa V Phelan;Laura M Sanchez

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

    Timothy P. Sheahan;Amy C. Sims;Sarah R. Leist;Alexandra Schäfer

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

    Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery

  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

    Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham

  • An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

    Timothy P. Sheahan;Amy C. Sims;Shuntai Zhou;Rachel L. Graham

  • Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture

    Aartjan J. W. te Velthuis;Sjoerd H. E. van den Worm;Amy C. Sims;Ralph S. Baric

  • Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

    Ariane J. Brown;John J. Won;Rachel L. Graham;Kenneth H. Dinnon

  • SARS-like WIV1-CoV poised for human emergence

    Vineet D. Menachery;Boyd L. Yount;Amy C Sims;Kari Debbink

  • Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs

    Amy C. Sims;Ralph S. Baric;Boyd Yount;Susan E. Burkett

  • Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

    Trevor Scobey;Boyd L. Yount;Amy C. Sims;Eric F. Donaldson

  • Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

    Michelle M. Becker;Rachel Lauren Graham;Eric F. Donaldson;Barry Rockx

  • Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

    Boyd Yount;Rhonda S. Roberts;Amy C. Sims;Damon Deming

  • Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.

    Maria L. Agostini;Andrea J. Pruijssers;James D. Chappell;Jennifer Gribble

  • Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

    Damon Deming;Timothy Sheahan;Mark Heise;Boyd Yount

  • Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

    Vineet D. Menachery;Amie J. Eisfeld;Alexandra Schäfer;Laurence Josset

  • Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

    Xingchuan Huang;Wenjuan Dong;Aleksandra Milewska;Anna Golda

  • MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

    Ernesto S. Nakayasu;Carrie D. Nicora;Amy C. Sims;Kristin E. Burnum-Johnson

  • The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication.

    Rachel L. Graham;Amy C. Sims;Sarah M. Brockway;Ralph S. Baric

  • MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

    Vineet D. Menachery;Alexandra Schäfer;Kristin E. Burnum-Johnson;Hugh D. Mitchell

  • SARS coronavirus replicase proteins in pathogenesis.

    Rachel L. Graham;Jennifer S. Sparks;Lance D. Eckerle;Amy C. Sims

Frequent Co-Authors

Ralph S. Baric
Ralph S. Baric University of North Carolina at Chapel Hill
Boyd Yount
Boyd Yount University of North Carolina at Chapel Hill
Katrina M. Waters
Katrina M. Waters Pacific Northwest National Laboratory
Timothy P. Sheahan
Timothy P. Sheahan University of North Carolina at Chapel Hill
Mark R. Denison
Mark R. Denison Vanderbilt University Medical Center
Vineet D. Menachery
Vineet D. Menachery The University of Texas Medical Branch at Galveston
Thomas O. Metz
Thomas O. Metz Pacific Northwest National Laboratory
Eric F. Donaldson
Eric F. Donaldson Center for Drug Evaluation and Research
Raymond J. Pickles
Raymond J. Pickles University of North Carolina at Chapel Hill
Lisa E. Gralinski
Lisa E. Gralinski University of North Carolina at Chapel Hill

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