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Biology and Biochemistry

D-Index
74
Citations
16042
World Ranking
5731
National Ranking
2710

Overview

Thomas O. Metz is affiliated with the Pacific Northwest National Laboratory in the United States. Their research spans a variety of topics mainly situated within Earth and Planetary Sciences, with a strong focus on interdisciplinary approaches combining geophysical, atmospheric, and molecular studies.

The main fields of study in Metz's body of work include Earth and Planetary Sciences with emphases on subfields such as Geophysics, Astronomy and Astrophysics, Oceanography, Environmental Chemistry, and Molecular Biology. This diverse focus supports investigations into natural phenomena from seismic activity to molecular transformations.

The scientist's principal research topics cover:

  • Seismic Waves and Analysis
  • Ionosphere and magnetosphere dynamics
  • Geophysics and Gravity Measurements
  • Methane Hydrates and Related Phenomena
  • Astrophysics and Cosmic Phenomena
  • Earthquake Detection and Analysis
  • Metabolomics and Mass Spectrometry Studies

Notable recent publications authored or co-authored by Metz include:

  • Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation, 2021, Nature Protocols
  • Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity, 2022, Nature Microbiology
  • BioTransformer 3.0-a web server for accurately predicting metabolic transformation products, 2022, Nucleic Acids Research
  • Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data, 2020, Nature Biotechnology
  • An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells, 2020, Nature Communications

Frequent co-authors collaborating with Metz include Charles Ansong, Richard Corley, Scott Baker, Aaron Wright, and Jason McDermott. This network reflects a broad interdisciplinary engagement across multiple domains of expertise.

The scientist has frequently published in venues such as OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information), bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, arXiv (Cornell University), and the DOE Pacific Northwest National Laboratory (PNNL) Repository.

Best Publications

  • Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

    Mingxun Wang;Jeremy J Carver;Vanessa V Phelan;Laura M Sanchez

  • Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

    Gil Sharon;Nikki Jamie Cruz;Dae Wook Kang;Michael J. Gandal

  • A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease

    Qibin Zhang;Jennifer M. Ames;Richard D. Smith;John W. Baynes

  • Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics.

    Deborah L. Diamond;Andrew J. Syder;Jon M. Jacobs;Christina M. Sorensen

  • Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells.

    Rushika Perera;Catherine Riley;Giorgis Isaac;Amber S. Hopf-Jannasch

  • Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease

    Kimberly Splinter;David R. Adams;Carlos A. Bacino;Hugo J. Bellen

  • Automated 20 kpsi RPLC-MS and MS/MS with Chromatographic Peak Capacities of 1000−1500 and Capabilities in Proteomics and Metabolomics

    Yufeng Shen;Rui Zhang;Ronald J. Moore;Jeongkwon Kim

  • Review, Evaluation, and Discussion of the Challenges of Missing Value Imputation for Mass Spectrometry-Based Label-Free Global Proteomics

    Bobbie Jo M Webb-Robertson;Holli K. Wiberg;Melissa M. Matzke;Joseph N. Brown

  • A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation

    Paul A. Voziyan;Thomas O. Metz;John W. Baynes;Billy G. Hudson

  • Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

    Vineet D. Menachery;Amie J. Eisfeld;Alexandra Schäfer;Laurence Josset

  • Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

    Ryoji Nagai;David B. Murray;Thomas O. Metz;John W. Baynes

  • Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

    Lisa E. Gralinski;Armand Bankhead;Sophia Jeng;Vineet D. Menachery

  • Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications.

    Thomas O Metz;Nathan L Alderson;Suzanne R Thorpe;John W Baynes

  • Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry

    Jennifer E. Kyle;Xing Zhang;Karl K. Weitz;Matthew E. Monroe

  • MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses

    Ernesto S. Nakayasu;Carrie D. Nicora;Amy C. Sims;Kristin E. Burnum-Johnson

  • MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

    Vineet D. Menachery;Alexandra Schäfer;Kristin E. Burnum-Johnson;Hugh D. Mitchell

  • A statistical framework for protein quantitation in bottom-up MS-based proteomics

    Yuliya Karpievitch;Jeff Stanley;Thomas Taverner;Jianhua Huang

  • MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.

    Julia Wang;Rami Al-Ouran;Yanhui Hu;Seon-Young Kim

  • Enrichment and analysis of nonenzymatically glycated peptides: boronate affinity chromatography coupled with electron-transfer dissociation mass spectrometry.

    Qibin Zhang;Ning Tang;Jonathan W. C. Brock;Heather M. Mottaz

  • Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation

    Aarash Bordbar;Monica L. Mo;Ernesto S. Nakayasu;Alexandra C. Schrimpe-Rutledge

Frequent Co-Authors

Richard D. Smith
Richard D. Smith Pacific Northwest National Laboratory
Katrina M. Waters
Katrina M. Waters Pacific Northwest National Laboratory
Ernesto S. Nakayasu
Ernesto S. Nakayasu Pacific Northwest National Laboratory
Janet K. Jansson
Janet K. Jansson Pacific Northwest National Laboratory
Ronald J. Moore
Ronald J. Moore Pacific Northwest National Laboratory
Matthew E. Monroe
Matthew E. Monroe Pacific Northwest National Laboratory
Monte Westerfield
Monte Westerfield University of Oregon
Joshua N. Adkins
Joshua N. Adkins Pacific Northwest National Laboratory
William A. Gahl
William A. Gahl National Institutes of Health
John W. Baynes
John W. Baynes University of South Carolina

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