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Chemistry

D-Index
61
Citations
12631
World Ranking
9288
National Ranking
2624

Research.com Recognitions

  • 2011 - Fellow of the American Chemical Society

Overview

Judy L. Bolton was a researcher affiliated with the University of Illinois at Chicago in the United States. Their academic contributions primarily focused on pharmacology, toxicology, pharmaceutics, and chemistry, with a significant emphasis on pharmacology and analytical chemistry within these fields.

The scientist's research extensively covered topics related to natural products, plant bioactivities, and chromatic techniques, notably:

  • Chromatography in Natural Products
  • Hops Chemistry and Applications
  • Phytoestrogen effects and research
  • Phytochemicals and Antioxidant Activities
  • Natural product bioactivities and synthesis
  • Medicinal Plant Pharmacodynamics Research
  • Genomics, phytochemicals, and oxidative stress

Judy L. Bolton contributed articles to several scientific journals, with recurrent publications in:

  • Journal of Agricultural and Food Chemistry
  • Cancer Research
  • Chemical Research in Toxicology
  • Scientific Reports
  • Phytochemistry

Their frequent collaborators included the following researchers:

  • Shao-Nong Chen
  • Guido F. Pauli
  • Caitlin Howell
  • Birgit M. Dietz
  • Atieh Hajirahimkhan

Recent notable publications by Judy L. Bolton included:

  • SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents (2020) published in Journal of Agricultural and Food Chemistry
  • Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women (2020) published in Journal of Agricultural and Food Chemistry
  • 6-Prenylnaringenin from Hops Disrupts ERα-Mediated Downregulation of CYP1A1 to Facilitate Estrogen Detoxification (2020) published in Chemical Research in Toxicology
  • Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women's breast tissue (2023) published in Scientific Reports
  • No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women (2020) published in Journal of Agricultural and Food Chemistry

Their work explored biochemical and molecular interactions with an emphasis on estrogen receptor activities, phytoestrogens, and dietary supplement pharmacokinetics, contributing to the understanding of natural product effects on drug metabolism and cancer prevention strategies.

Judy L. Bolton was recognized as a Fellow of the American Chemical Society in 2011, indicating a level of distinction within the chemical sciences community during their career.

Best Publications

  • Role of quinones in toxicology.

    Judy L. Bolton;Michael A. Trush;Trevor M. Penning;Glenn Dryhurst

  • Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

    Jianghua Liu;Joanna E. Burdette;Haiyan Xu;Chungang Gu

  • Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

    Judy L. Bolton;Tareisha Dunlap

  • Potential mechanisms of estrogen quinone carcinogenesis.

    Judy L. Bolton;Gregory R. J. Thatcher

  • Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

    Birgit M. Dietz;Young Hwa Kang;Guowen Liu;Aimee L. Eggler

  • Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.

    Joanna E Burdette;Jianghua Liu;Shao-Nong Chen;Daniel S Fabricant

  • Role of quinoids in estrogen carcinogenesis.

    Judy L. Bolton;Emily Pisha;Fagen Zhang;Shengxiang Qiu

  • Botanicals and Their Bioactive Phytochemicals for Women's Health.

    Birgit M. Dietz;Atieh Hajirahimkhan;Tareisha L. Dunlap;Judy L. Bolton

  • Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.

    Shixin Deng;Shao Nong Chen;Ping Yao;Dejan Nikolic

  • Comparison of the in Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense)

    Cassia R. Overk;Ping Yao;Lucas R. Chadwick;Dejan Nikolic

  • Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.

    Zhihui Qin;Irida Kastrati;R. Esala P Chandrasena;Hong Liu

  • Estrogens and congeners from spent hops (Humulus lupulus).

    Lucas R. Chadwick;Dejan Nikolic;Joanna E. Burdette;Cassia R. Overk

  • Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.

    Nancy L. Booth;Cassia R. Overk;Ping Yao;Steve Totura

  • Black Cohosh (Cimicifuga racemosa L.) Protects against Menadione-Induced DNA Damage through Scavenging of Reactive Oxygen Species: Bioassay-Directed Isolation and Characterization of Active Principles

    Joanna E. Burdette;Shao Nong Chen;Zhi Zhen Lu;Haiyan Xu

  • Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: potential bioactivation mechanism for the hepatocarcinogen safrole.

    Judy L. Bolton;Nick M. Acay;Vesna Vukomanovic

  • Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens.

    Judy L Bolton

  • The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.

    Nancy L. Booth;Cassia R. Overk;Ping Yao;Joanna E. Burdette

  • Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).

    J. Liu;J.E. Burdette;Y. Sun;S. Deng

  • Trifolium pratense (Red Clover) Exhibits Estrogenic Effects In Vivo in Ovariectomized Sprague-Dawley Rats

    Joanna E. Burdette;Jianghua Liu;Dan Lantvit;Eula Lim

  • The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.

    Fagen Zhang;Yumei Chen;E. Pisha;Li Shen

  • 4-Hydroxylated Metabolites of the Antiestrogens Tamoxifen and Toremifene Are Metabolized to Unusually Stable Quinone Methides

    Peter W. Fan;Fagen Zhang;Judy L. Bolton

Frequent Co-Authors

Richard B. van Breemen
Richard B. van Breemen Oregon State University
Guido F. Pauli
Guido F. Pauli University of Illinois at Chicago
Shao-Nong Chen
Shao-Nong Chen University of Illinois at Chicago
Norman R. Farnsworth
Norman R. Farnsworth University of Illinois at Chicago
John M. Pezzuto
John M. Pezzuto Western New England University
Nicholas E. Geacintov
Nicholas E. Geacintov New York University
Harry H. S. Fong
Harry H. S. Fong University of Illinois at Chicago
Andrew D. Mesecar
Andrew D. Mesecar Purdue University West Lafayette
Suse Broyde
Suse Broyde New York University
Sang Kook Lee
Sang Kook Lee Seoul National University

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