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Philipp J. Kahle

Philipp J. Kahle

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
17947
World Ranking
8567
National Ranking
630

Overview

Philipp J. Kahle is affiliated with the University of Tübingen in Germany and has contributed extensively to the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their work spans numerous subfields including Neurology, Molecular Biology, Physiology, Epidemiology, and Cellular and Molecular Neuroscience.

The main topics of their research include Parkinson's Disease Mechanisms and Treatments, Alzheimer's Disease Research and Treatments, Autophagy in Disease and Therapy, Neuroinflammation and Neurodegeneration Mechanisms, Mitochondrial Function and Pathology, Amyotrophic Lateral Sclerosis Research, and Nerve Injury and Regeneration.

Philipp J. Kahle's recent scholarly articles demonstrate a focus on molecular and neurodegenerative processes. Key papers include:

  • Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43 (2022), published in Nature Communications
  • LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies (2021), published in EMBO Molecular Medicine
  • Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice (2020), published in Proceedings of the National Academy of Sciences
  • Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules (2020), published in Journal of Biological Chemistry
  • Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions (2020), published in Acta Neuropathologica Communications

The publication venues where Philipp J. Kahle frequently contributes include the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, iScience, bioRxiv (Cold Spring Harbor Laboratory), and Nature Communications.

Their collaborative work often involves several frequent co-authors, such as Mathias Jucker, Anna Lechado-Terradas, Christian Johannes Gloeckner, Mehtap Bacioglu, and Katharina Zittlau, indicating teamwork in ongoing research projects.

Best Publications

  • PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

    Sven Geisler;Kira M. Holmström;Diana Skujat;Fabienne C. Fiesel

  • Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

    Philipp J. Kahle;Manuela Neumann;Laurence Ozmen;Veronika Müller

  • Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein *

    Masayasu Okochi;Jochen Walter;Akihiko Koyama;Shigeo Nakajo

  • Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

    Nicole Exner;Bettina Treske;Dominik Paquet;Kira Holmström

  • Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

    Mehtap Bacioglu;Luis F. Maia;Oliver Preische;Juliane Schelle;Juliane Schelle

  • DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders.

    Philipp J. Kahle;Jens Waak;Thomas Gasser

  • Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

    Manuela Neumann;Philipp J. Kahle;Benoit I. Giasson;Laurence Ozmen

  • Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

    Guido Krebiehl;Sabine Ruckerbauer;Lena F. Burbulla;Nicole Kieper

  • The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.

    Sven Geisler;Kira M. Holmström;Angela Treis;Diana Skujat

  • Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes

    Philipp J Kahle;Manuela Neumann;Laurence Ozmen;Veronika Müller

  • Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

    Philipp J. Kahle;Manuela Neumann;Laurence Ozmen;Veronika Müller

  • Microglial activation mediates neurodegeneration related to oligodendroglial α-synucleinopathy: Implications for multiple system atrophy

    Nadia Stefanova;Markus Reindl;Manuela Neumann;Philipp J. Kahle

  • α-Synuclein has a high affinity for packing defects in a bilayer membrane. A thermodynamics study

    Brigitte Nuscher;Frits Kamp;Thomas Mehnert;Sabine Odoy

  • Phosphorylation of synucleins by members of the Polo-like kinase family.

    Martial K. Mbefo;Katerina E. Paleologou;Ahmed Boucharaba;Abid Oueslati

  • Oxidative Stress in Transgenic Mice with Oligodendroglial α-Synuclein Overexpression Replicates the Characteristic Neuropathology of Multiple System Atrophy

    Nadia Stefanova;Markus Reindl;Manuela Neumann;Christian Haass

  • Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

    Fabienne C Fiesel;Aaron Voigt;Stephanie S Weber;Chris Van den Haute

  • Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

    Syed Z. Imam;Qing Zhou;Ayako Yamamoto;Anthony J. Valente

  • Neuropathology in Mice Expressing Mouse Alpha-Synuclein

    Claus Rieker;Kumlesh K. Dev;Katja Lehnhoff;Samuel Barbieri

  • TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity

    Aaron Voigt;David Herholz;Fabienne C. Fiesel;Kavita Kaur

  • Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice

    Christian Freichel;Manuela Neumann;Theresa Ballard;Veronika Müller

Frequent Co-Authors

Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Manuela Neumann
Manuela Neumann University of Tübingen
Thomas Gasser
Thomas Gasser University of Tübingen
Hans A. Kretzschmar
Hans A. Kretzschmar Ludwig-Maximilians-Universität München
Rejko Krüger
Rejko Krüger University of Luxembourg
Martin Ingelsson
Martin Ingelsson Uppsala University
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Lars Lannfelt
Lars Lannfelt Uppsala University
Jörg B. Schulz
Jörg B. Schulz RWTH Aachen University
Olaf Riess
Olaf Riess University of Tübingen

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