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Molecular Biology

D-Index
75
Citations
20127
World Ranking
1194
National Ranking
92

Overview

Axel Mogk is affiliated with Heidelberg University in Germany and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their work primarily focuses on molecular and cellular biology topics, with a significant emphasis on the mechanisms and functions of heat shock proteins and related proteostasis processes.

Their research spans several subfields, including Molecular Biology, Cell Biology, Biotechnology, Genetics, and Endocrinology. A considerable portion of their publications addresses the role of heat shock proteins in maintaining protein homeostasis, alongside studies on endoplasmic reticulum stress and its implications for disease.

Key topics featured in their research include:

  • Heat shock proteins research
  • Endoplasmic Reticulum Stress and Disease
  • Protein Structure and Dynamics
  • Bacterial Genetics and Biotechnology
  • Ubiquitin and proteasome pathways
  • Fungal and yeast genetics research
  • Peptidase Inhibition and Analysis

Axel Mogk has published notably in venues such as the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), eLife, The EMBO Journal, and Nature. These publication venues highlight their focus on biochemical and molecular insights derived from experimental and review articles.

Their recent papers include:

  • Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species (2020, Journal of Biological Chemistry)
  • Processive extrusion of polypeptide loops by a Hsp100 disaggregase (2020, Nature)
  • The Diverse Functions of Small Heat Shock Proteins in the Proteostasis Network (2021, Journal of Molecular Biology)
  • The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species (2020, The EMBO Journal)
  • Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions (2020, Cell Reports)

Mogk frequently collaborates with other researchers, with notable co-authors including Bernd Bukau, Panagiotis Katikaridis, Carmen Ruger-Herreros, Timo Jenne, and Fabian den Brave. These collaborations reflect a network of scientists working together in overlapping areas of molecular chaperones and protein quality control mechanisms.

Best Publications

  • Cellular strategies for controlling protein aggregation

    Jens Tyedmers;Axel Mogk;Bernd Bukau

  • Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

    Pierre Goloubinoff;Axel Mogk;Anat Peres Ben Zvi;Toshifumi Tomoyasu

  • Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

    Axel Mogk;Toshifumi Tomoyasu;Pierre Goloubinoff;Stefan Rüdiger

  • Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones

    Thomas Laufen;Matthias P. Mayer;Christian Beisel;Dagmar Klostermeier

  • Trigger factor and DnaK cooperate in folding of newly synthesized proteins.

    Elke Deuerling;Agnes Schulze-Specking;Toshifumi Tomoyasu;Axel Mogk

  • Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB

    Jimena Weibezahn;Peter Tessarz;Christian Schlieker;Regina Zahn

  • Small heat shock proteins, ClpB and the DnaK system form a functional triade in reversing protein aggregation.

    Axel Mogk;Elke Deuerling;Sonja Vorderwülbecke;Elizabeth Vierling

  • Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion.

    Gabriele Bönemann;Aleksandra Pietrosiuk;Alexander Diemand;Hanswalter Zentgraf

  • Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol.

    Toshifumi Tomoyasu;Axel Mogk;Hanno Langen;Pierre Goloubinoff

  • Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

    Xuechao Gao;Xuechao Gao;Marta Carroni;Carmen Nussbaum-Krammer;Carmen Nussbaum-Krammer;Axel Mogk;Axel Mogk

  • Cellular Handling of Protein Aggregates by Disaggregation Machines.

    Axel Mogk;Bernd Bukau;Harm H. Kampinga

  • The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies.

    Axel Mogk;Ronny Schmidt;Bernd Bukau

  • The GroE chaperonin machine is a major modulator of the CIRCE heat shock regulon of Bacillus subtilis

    Axel Mogk;Georg Homuth;Christian Scholz;Lana Kim

  • Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

    Axel Mogk;Christian Schlieker;Kenneth L. Friedrich;Hans-Joachim Schönfeld

  • Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

    Sebastian Specht;Stephanie B.M. Miller;Axel Mogk;Bernd Bukau

  • Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli.

    Ario de Marco;Elke Deuerling;Axel Mogk;Toshifumi Tomoyasu

  • Quantitative and spatio‐temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

    Juliane Winkler;Anja Seybert;Lars König;Sabine Pruggnaller

  • Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

    Stephanie B M Miller;Chi-Ting Ho;Juliane Winkler;Maria Khokhrina

  • Roles of Individual Domains and Conserved Motifs of the AAA+ Chaperone ClpB in Oligomerization, ATP Hydrolysis, and Chaperone Activity

    Axel Mogk;Christian Schlieker;Christine Strub;Wolfgang Rist

  • A xylose-inducible Bacillus subtilis integration vector and its application.

    Lana Kim;Axel Mogk;Wolfgang Schumann

Frequent Co-Authors

Bernd Bukau
Bernd Bukau Heidelberg University
Wolfgang Schumann
Wolfgang Schumann University of Bayreuth
Pierre Goloubinoff
Pierre Goloubinoff University of Lausanne
Harm H. Kampinga
Harm H. Kampinga University Medical Center Groningen
Ute Römling
Ute Römling Karolinska Institute
Luc Bousset
Luc Bousset Centre national de la recherche scientifique, CNRS
Ronald Melki
Ronald Melki Centre national de la recherche scientifique, CNRS
Helen R. Saibil
Helen R. Saibil Birkbeck, University of London
Hanno Langen
Hanno Langen Roche (Switzerland)
Heinrich Lünsdorf
Heinrich Lünsdorf Helmholtz Centre for Infection Research

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