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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
19293
World Ranking
11729
National Ranking
5044

Research.com Recognitions

  • 2002 - Hellman Fellow

Overview

Marc I. Diamond is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research focuses primarily on the intersection of biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on neurodegenerative diseases and molecular mechanisms underlying these conditions.

The main fields of study for Diamond's work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their research spans several subfields including:

  • Molecular Biology
  • Physiology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Cell Biology

The major topics covered by Diamond's publications are:

  • Alzheimer's disease research and treatments
  • Prion Diseases and Protein Misfolding
  • Neuroscience and Neuropharmacology Research
  • Cellular transport and secretion
  • Protein Structure and Dynamics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Heat shock proteins research

Diamond has frequently published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Acta Neuropathologica Communications
  • Alzheimer's & Dementia
  • Nature Communications

Frequent collaborators include:

  • Charles L. White
  • Łukasz A. Joachimiak
  • Jaime Vaquer-Alicea
  • Ankit Gupta
  • Vishruth Mullapudi

Some notable recent papers authored by Diamond are:

  • "Tau strains shape disease," 2021, Acta Neuropathologica
  • "Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF," 2021, Acta Neuropathologica Communications
  • "The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system," 2023, Nature Communications
  • "Fate and propagation of endogenously formed Tau aggregates in neuronal cells," 2020, EMBO Molecular Medicine
  • "Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming," 2024, Science

Throughout their career, Diamond has been recognized with awards such as the Hellman Fellow in 2002.

Best Publications

  • Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

    Marc I. Diamond;Jeffrey N. Miner;Steven K. Yoshinaga;Keith R. Yamamoto

  • Propagation of Tau Misfolding from the Outside to the Inside of a Cell

    Bess Frost;Rachel L. Jacks;Marc I. Diamond

  • Distinct tau prion strains propagate in cells and mice and define different tauopathies.

    David W. Sanders;Sarah K. Kaufman;Sarah L. DeVos;Apurwa M. Sharma

  • Neuronal activity enhances tau propagation and tau pathology in vivo

    Jessica W Wu;S Abid Hussaini;Isle M Bastille;Gustavo A Rodriguez

  • Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

    Brandon B. Holmes;Sarah L. DeVos;Najla Kfoury;Mei Li

  • Prion-like mechanisms in neurodegenerative diseases.

    Bess Frost;Marc I. Diamond

  • Proteopathic tau seeding predicts tauopathy in vivo

    Brandon B. Holmes;Jennifer L. Furman;Thomas E. Mahan;Tritia R. Yamasaki

  • Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

    Kiran Yanamandra;Najla Kfoury;Hong Jiang;Thomas E. Mahan

  • Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

    Najla Kfoury;Brandon B. Holmes;Hong Jiang;David M. Holtzman

  • Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

    Sarah L. DeVos;Rebecca L. Miller;Kathleen M. Schoch;Brandon B. Holmes

  • Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.

    Sarah K. Kaufman;David W. Sanders;David W. Sanders;Talitha L. Thomas;Allison J. Ruchinskas

  • In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

    Kaoru Yamada;John R. Cirrito;Floy R. Stewart;Hong Jiang

  • Polyglutamine diseases: emerging concepts in pathogenesis and therapy

    Jieya Shao;Marc I. Diamond

  • Mechanisms of protein seeding in neurodegenerative diseases.

    Lary C. Walker;Marc I. Diamond;Karen E. Duff;Bradley T. Hyman

  • The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions

    Fred Schaufele;Xavier Carbonell;Martin Guerbadot;Sabine Borngraeber

  • Propagation of Protein Aggregation in Neurodegenerative Diseases.

    Jaime Vaquer-Alicea;Marc I. Diamond

  • Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

    Bess Frost;Julian Ollesch;Holger Wille;Marc I. Diamond

  • Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

    Sarah K. Kaufman;Sarah K. Kaufman;Kelly Del Tredici;Talitha L. Thomas;Heiko Braak

  • Propagation of prions causing synucleinopathies in cultured cells

    Amanda L. Woerman;Jan Stöhr;Atsushi Aoyagi;Ryan Rampersaud

  • Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.

    Hilda Mirbaha;Brandon B. Holmes;David W. Sanders;Jan Bieschke

Frequent Co-Authors

David M. Holtzman
David M. Holtzman Washington University in St. Louis
Hong Jiang
Hong Jiang Nanjing Tech University
Heiko Braak
Heiko Braak University of Ulm
Keith R. Yamamoto
Keith R. Yamamoto University of California, San Francisco
Conrad C. Weihl
Conrad C. Weihl Washington University in St. Louis
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Linda C. Hsieh-Wilson
Linda C. Hsieh-Wilson California Institute of Technology
Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Naoki Takahashi
Naoki Takahashi Nara Institute of Science and Technology
Karen Duff
Karen Duff University College London

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