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Biology and Biochemistry

D-Index
53
Citations
10127
World Ranking
16165
National Ranking
6698

Research.com Recognitions

  • 2015 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - Fellow of Alfred P. Sloan Foundation

Overview

Linda C. Hsieh-Wilson is affiliated with the California Institute of Technology in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to the fields of chemistry and molecular biology, cell biology, and organic chemistry.

The scientist's work covers several specific topics, including:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and glycoproteins research
  • Carbohydrate chemistry and synthesis
  • Platelet disorders and treatments
  • Ubiquitin and proteasome pathways
  • Fibroblast growth factor research
  • Connective tissue disorders research

Among their recent papers are:

  • "Tools for mammalian glycoscience research," 2022, Cell
  • "Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan-protein interactions," 2023, Nature Chemistry
  • "Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory," 2023, Proceedings of the National Academy of Sciences
  • "Sulfated glycans engage the Ang-Tie pathway to regulate vascular development," 2020, Nature Chemical Biology
  • "Synthesis of a Systematic 64-Membered Heparan Sulfate Tetrasaccharide Library," 2022, Angewandte Chemie International Edition

Their frequent co-authors include Xuefei Huang, Jian Liu, Kedar N. Baryal, Chang-Xin Huo, and Guowei Su.

Linda C. Hsieh-Wilson has published extensively in several venues including:

  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Proceedings of the National Academy of Sciences
  • Journal of the American Chemical Society
  • Cell

The scientist has been recognized with several fellowships throughout their career:

  • Fellow of the American Academy of Arts and Sciences, 2015
  • Fellow of the American Association for the Advancement of Science (AAAS), 2007
  • Fellow of Alfred P. Sloan Foundation, 2003

Best Publications

  • Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

    Wen Yi;Peter M. Clark;Daniel E. Mason;Marie C. Keenan

  • Sulfation patterns of glycosaminoglycans encode molecular recognition and activity

    Cristal I Gama;Sarah E Tully;Naoki Sotogaku;Peter M Clark

  • Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

    Nelly Khidekel;Scott B. Ficarro;Eric C. Peters;Linda C. Hsieh-Wilson

  • Probing the dynamics of O -GlcNAc glycosylation in the brain using quantitative proteomics

    Nelly Khidekel;Scott B Ficarro;Peter M Clark;Marian C Bryan

  • Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin.

    Zhen Yan;Linda Hsieh-Wilson;Jian Feng;Kazuhito Tomizawa

  • A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications.

    Nelly Khidekel;Sabine Arndt;Nathan Lamarre-Vincent;Alexander Lippert

  • Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays

    Eric L. Shipp;Linda C. Hsieh-Wilson

  • dynamic O-Glcnac modification regulates CreB- mediated gene expression and memory formation

    Jessica E Rexach;Peter M Clark;Daniel E Mason;Rachael L Neve

  • The chemical neurobiology of carbohydrates.

    Heather E. Murrey;Linda C. Hsieh-Wilson

  • A chondroitin sulfate small molecule that stimulates neuronal growth.

    Sarah E. Tully;Ross Mabon;Cristal I. Gama;Sherry M. Tsai

  • Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.

    Andrew C. Wang;Elizabeth H. Jensen;Jessica E. Rexach;Harry V. Vinters

  • Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags

    Jessica E Rexach;Claude J Rogers;Seok-Ho Yu;Jifang Tao

  • Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation

    Parameswaran Ramakrishnan;Peter M. Clark;Daniel E. Mason;Eric C. Peters

  • Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes.

    Zihao Wang;Kyoungsook Park;Frank Comer;Linda C. Hsieh-Wilson

  • Chemical approaches to deciphering the glycosaminoglycan code

    Cristal I Gama;Linda C Hsieh-Wilson

  • A sulfated carbohydrate epitope inhibits axon regeneration after injury

    Joshua M. Brown;Jiang Xia;BinQuan Zhuang;Kin-Sang Cho

  • Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

    Jennifer N. Rauch;John J. Chen;Alexander W. Sorum;Gregory M. Miller

  • A ‘molecular switchboard’—covalent modifications to proteins and their impact on transcription

    Nelly Khidekel;Linda C. Hsieh-Wilson

  • Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation.

    Nathan Lamarre-Vincent;Linda C. Hsieh-Wilson

  • CHARACTERIZATION OF THE NEURONAL TARGETING PROTEIN SPINOPHILIN AND ITS INTERACTIONS WITH PROTEIN PHOSPHATASE-1

    Linda C. Hsieh-Wilson;Patrick B. Allen;Takuo Watanabe;and Angus C. Nairn

Frequent Co-Authors

Eric C. Peters
Eric C. Peters Genomics Institute of the Novartis Research Foundation
Angus C. Nairn
Angus C. Nairn Yale University
Paul Greengard
Paul Greengard Rockefeller University
William A. Goddard
William A. Goddard California Institute of Technology
Scott B. Ficarro
Scott B. Ficarro Harvard University
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Akinori Nishi
Akinori Nishi Kurume University
Marc I. Diamond
Marc I. Diamond The University of Texas Southwestern Medical Center
Zhen Yan
Zhen Yan University at Buffalo, State University of New York
Jian Feng
Jian Feng University at Buffalo, State University of New York

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