Amanda J. Fosang focuses on Aggrecan, Cartilage, Biochemistry, Aggrecanase and Proteoglycan. Amanda J. Fosang combines subjects such as Cartilage metabolism, ADAMTS, ADAMTS4 Protein, Molecular biology and Extracellular matrix with her study of Aggrecan. Her studies deal with areas such as Chromatography and Binding site as well as Molecular biology.
Her study in Cartilage is interdisciplinary in nature, drawing from both Matrix metalloproteinase, Metalloproteinase and Cell biology. Cell biology connects with themes related to Immunology in her study. Her research investigates the connection between Aggrecanase and topics such as Arthritis that intersect with problems in Chondroitin and Proteolysis.
The scientist’s investigation covers issues in Aggrecan, Cartilage, Cell biology, Biochemistry and Aggrecanase. Her work deals with themes such as Molecular biology, Cleavage, ADAMTS, Proteoglycan and Matrix metalloproteinase, which intersect with Aggrecan. Her Cartilage study combines topics in areas such as Arthritis, Extracellular matrix and Matrix, Pathology.
Her Cell biology course of study focuses on In vitro and In vivo. Her work in the fields of Biochemistry, such as Keratan sulfate, Chondroitin sulfate, Binding site and Gelatinases, intersects with other areas such as Population. Her biological study spans a wide range of topics, including Chondroitin, ADAMTS4 Protein, Enzyme activator, Epitope and Retinoic acid.
Amanda J. Fosang mostly deals with Aggrecan, Cell biology, Cartilage, Metalloproteinase and ADAMTS. Her studies in Aggrecan integrate themes in fields like Biophysics, In vitro model and Aggrecanase. Her research in Cell biology intersects with topics in Chondrocyte, Matrix metalloproteinase and Endochondral ossification.
Her Matrix metalloproteinase research focuses on Matrix and how it connects with Proteoglycan. Her research integrates issues of Arthritis, Cancer research and Gene expression profiling in her study of Cartilage. The study incorporates disciplines such as ADAMTS4 Protein and Retinoic acid in addition to ADAMTS.
Amanda J. Fosang mainly focuses on Cartilage, Cell biology, Aggrecan, Extracellular matrix and Regeneration. Her Cartilage study combines topics from a wide range of disciplines, such as Microarray analysis techniques, Aggrecanase and Pathology. Amanda J. Fosang interconnects Joint pain and Anatomy in the investigation of issues within Cell biology.
She connects Aggrecan with microRNA in her research. Her research in Regeneration intersects with topics in Proteases, Chondrocyte and Bioinformatics. The Metalloproteinase study combines topics in areas such as Molecular biology, Protease and Aortic wall, Aorta.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Proteoglycans: many forms and many functions.
Timothy E. Hardingham;Amanda J. Fosang.
The FASEB Journal (1992)
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
Heather Stanton;Fraser M. Rogerson;Charlotte J. East;Suzanne B. Golub.
Nature (2005)
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
Dominique Stickens;Danielle J. Behonick;Nathalie Ortega;Babette Heyer.
Development (2004)
MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT
C. B. Little;A. Barai;D. Burkhardt;S. M. Smith.
Arthritis & Rheumatism (2009)
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Amanda J. Fosang;Vera Knäuper;Gillian Murphy.
FEBS Letters (1996)
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
Amanda J Fosang;Peter J Neame;Tim E Hardingham.
Journal of Biological Chemistry (1992)
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
C E Hughes;B Caterson;A J Fosang;P J Roughley.
Biochemical Journal (1995)
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
A J Fosang;R A Maciewicz.
Journal of Clinical Investigation (1996)
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
Christopher B. Little;Clare T. Meeker;Suzanne B. Golub;Kate E. Lawlor.
Journal of Clinical Investigation (2007)
Proteoglycan degradation by the ADAMTS family of proteinases.
Heather Stanton;James Melrose;Christopher B. Little;Amanda J. Fosang.
Biochimica et Biophysica Acta (2011)
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