D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 57 Citations 11,622 125 World Ranking 9368 National Ranking 255

Overview

What is she best known for?

The fields of study she is best known for:

  • Enzyme
  • Biochemistry
  • Genetics

Amanda J. Fosang focuses on Aggrecan, Cartilage, Biochemistry, Aggrecanase and Proteoglycan. Amanda J. Fosang combines subjects such as Cartilage metabolism, ADAMTS, ADAMTS4 Protein, Molecular biology and Extracellular matrix with her study of Aggrecan. Her studies deal with areas such as Chromatography and Binding site as well as Molecular biology.

Her study in Cartilage is interdisciplinary in nature, drawing from both Matrix metalloproteinase, Metalloproteinase and Cell biology. Cell biology connects with themes related to Immunology in her study. Her research investigates the connection between Aggrecanase and topics such as Arthritis that intersect with problems in Chondroitin and Proteolysis.

Her most cited work include:

  • Proteoglycans: many forms and many functions. (1009 citations)
  • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro (731 citations)
  • Altered endochondral bone development in matrix metalloproteinase 13-deficient mice (482 citations)

What are the main themes of her work throughout her whole career to date?

The scientist’s investigation covers issues in Aggrecan, Cartilage, Cell biology, Biochemistry and Aggrecanase. Her work deals with themes such as Molecular biology, Cleavage, ADAMTS, Proteoglycan and Matrix metalloproteinase, which intersect with Aggrecan. Her Cartilage study combines topics in areas such as Arthritis, Extracellular matrix and Matrix, Pathology.

Her Cell biology course of study focuses on In vitro and In vivo. Her work in the fields of Biochemistry, such as Keratan sulfate, Chondroitin sulfate, Binding site and Gelatinases, intersects with other areas such as Population. Her biological study spans a wide range of topics, including Chondroitin, ADAMTS4 Protein, Enzyme activator, Epitope and Retinoic acid.

She most often published in these fields:

  • Aggrecan (71.64%)
  • Cartilage (54.48%)
  • Cell biology (39.55%)

What were the highlights of her more recent work (between 2015-2019)?

  • Aggrecan (71.64%)
  • Cell biology (39.55%)
  • Cartilage (54.48%)

In recent papers she was focusing on the following fields of study:

Amanda J. Fosang mostly deals with Aggrecan, Cell biology, Cartilage, Metalloproteinase and ADAMTS. Her studies in Aggrecan integrate themes in fields like Biophysics, In vitro model and Aggrecanase. Her research in Cell biology intersects with topics in Chondrocyte, Matrix metalloproteinase and Endochondral ossification.

Her Matrix metalloproteinase research focuses on Matrix and how it connects with Proteoglycan. Her research integrates issues of Arthritis, Cancer research and Gene expression profiling in her study of Cartilage. The study incorporates disciplines such as ADAMTS4 Protein and Retinoic acid in addition to ADAMTS.

Between 2015 and 2019, her most popular works were:

  • An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. (39 citations)
  • Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation. (21 citations)
  • Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation. (21 citations)

In her most recent research, the most cited papers focused on:

  • Enzyme
  • Genetics
  • Biochemistry

Amanda J. Fosang mainly focuses on Cartilage, Cell biology, Aggrecan, Extracellular matrix and Regeneration. Her Cartilage study combines topics from a wide range of disciplines, such as Microarray analysis techniques, Aggrecanase and Pathology. Amanda J. Fosang interconnects Joint pain and Anatomy in the investigation of issues within Cell biology.

She connects Aggrecan with microRNA in her research. Her research in Regeneration intersects with topics in Proteases, Chondrocyte and Bioinformatics. The Metalloproteinase study combines topics in areas such as Molecular biology, Protease and Aortic wall, Aorta.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Proteoglycans: many forms and many functions.

Timothy E. Hardingham;Amanda J. Fosang.
The FASEB Journal (1992)

1632 Citations

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton;Fraser M. Rogerson;Charlotte J. East;Suzanne B. Golub.
Nature (2005)

956 Citations

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

Dominique Stickens;Danielle J. Behonick;Nathalie Ortega;Babette Heyer.
Development (2004)

790 Citations

MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT

C. B. Little;A. Barai;D. Burkhardt;S. M. Smith.
Arthritis & Rheumatism (2009)

599 Citations

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

Amanda J. Fosang;Vera Knäuper;Gillian Murphy.
FEBS Letters (1996)

512 Citations

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

Amanda J Fosang;Peter J Neame;Tim E Hardingham.
Journal of Biological Chemistry (1992)

353 Citations

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

C E Hughes;B Caterson;A J Fosang;P J Roughley.
Biochemical Journal (1995)

324 Citations

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

A J Fosang;R A Maciewicz.
Journal of Clinical Investigation (1996)

251 Citations

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Christopher B. Little;Clare T. Meeker;Suzanne B. Golub;Kate E. Lawlor.
Journal of Clinical Investigation (2007)

228 Citations

Proteoglycan degradation by the ADAMTS family of proteinases.

Heather Stanton;James Melrose;Christopher B. Little;Amanda J. Fosang.
Biochimica et Biophysica Acta (2011)

220 Citations

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