Peter J. Neame mostly deals with Biochemistry, Aggrecan, Molecular biology, Proteoglycan and Peptide sequence. His Biochemistry research is mostly focused on the topic Cleavage. Peter J. Neame interconnects ADAMTS4 Protein, Synovial fluid and Aggrecanase in the investigation of issues within Aggrecan.
The study of Extracellular matrix and Cartilage are components of his Proteoglycan research. His Cartilage research is multidisciplinary, relying on both Matrix metalloproteinase, Metalloproteinase and Cell biology. The study incorporates disciplines such as Amino acid, Leucine-rich repeat and Biglycan in addition to Peptide sequence.
His primary areas of investigation include Biochemistry, Proteoglycan, Peptide sequence, Molecular biology and Cartilage. He applies his multidisciplinary studies on Biochemistry and Aggrecan in his research. His Aggrecan research integrates issues from ADAMTS4 Protein, Synovial fluid and Aggrecanase.
The concepts of his Proteoglycan study are interwoven with issues in Iduronic acid, Glycoprotein, Glycosaminoglycan and Peptide. His research investigates the connection between Peptide sequence and topics such as Cysteine that intersect with problems in C-terminus. In Molecular biology, Peter J. Neame works on issues like Complementary DNA, which are connected to Furin.
His primary areas of study are Molecular biology, Biochemistry, Cell biology, Peptide sequence and Complementary DNA. The Molecular biology study combines topics in areas such as Fibroblast growth factor receptor 4, Fibroblast growth factor receptor, Fibroblast growth factor receptor 3, Fibroblast growth factor receptor 2 and Gene isoform. His work in the fields of Biochemistry, such as Proteoglycan and Small Leucine-Rich Proteoglycans, overlaps with other areas such as Aggrecan.
His Cell biology study integrates concerns from other disciplines, such as Receptor, Chromosome, Cartilage and Transfection. His study on Amino acid sequence analysis is often connected to Text mining, Terminal and Asporin as part of broader study in Peptide sequence. His work deals with themes such as Conserved sequence and Radiation hybrid mapping, Gene mapping, which intersect with Complementary DNA.
His main research concerns Biochemistry, Proteoglycan, Aggrecan, Extracellular matrix and Molecular biology. His study in the fields of Chondroitin sulfate under the domain of Biochemistry overlaps with other disciplines such as Asporin. He combines subjects such as Biophysics and Fibril formation with his study of Proteoglycan.
His Extracellular matrix research includes themes of Chondrocyte, Cartilage, Endochondral ossification and Type II collagen. His Molecular biology research includes elements of Biglycan, Decorin, Leucine-rich repeat, Protein family and Peptide sequence. His Decorin research incorporates elements of Fibril, Fibrillogenesis and Consensus sequence.
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The structure of aggrecan fragments in human synovial fluid : Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
L. Stefan Lohmander;Peter J. Neame;John D. Sandy.
Arthritis & Rheumatism (1993)
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
J D Sandy;C R Flannery;P J Neame;L S Lohmander.
Journal of Clinical Investigation (1992)
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
Amanda J. Fosang;Vera Knäuper;Gillian Murphy.
FEBS Letters (1996)
Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.
J D Sandy;P J Neame;R E Boynton;C R Flannery.
Journal of Biological Chemistry (1991)
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
Amanda J Fosang;Peter J Neame;Tim E Hardingham.
Journal of Biological Chemistry (1992)
Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.
Pilar Lorenzo;Anders Aspberg;Patrik Önnerfjord;Michael T. Bayliss.
Journal of Biological Chemistry (2001)
The primary structure of the core protein of the small, leucine-rich proteoglycan (PG I) from bovine articular cartilage
P J Neame;H U Choi;L C Rosenberg.
Journal of Biological Chemistry (1989)
The link proteins
P J Neame;F P Barry.
Cellular and Molecular Life Sciences (1993)
The Structure of Aggrecan Fragments in Human Synovial Fluid
John D. Sandy;R. Flannery;Peter J. Neame;L. Stefan Lohmanderl.
Independent modulation of collagen fibrillogenesis by decorin and lumican
P. J. Neame;C. J. Kay;D. J. McQuillan;M. P. Beales.
Cellular and Molecular Life Sciences (2000)
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