Clare Elizabeth Hughes

Overview

Best Publications

• The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis.

  Jan Bondeson;Shane Daniel Wainwright;Sarah Nicol Lauder;Nick Amos

  628
  Citations

• The role of synovial macrophages and macrophage‐produced mediators in driving inflammatory and destructive responses in osteoarthritis

  Jan Bondeson;Arjen B. Blom;Shane Daniel Wainwright;Clare Hughes

  520
  Citations

• Articular Cartilage Superficial Zone Protein (SZP) Is Homologous to Megakaryocyte Stimulating Factor Precursor and Is a Multifunctional Proteoglycan with Potential Growth-Promoting, Cytoprotective, and Lubricating Properties in Cartilage Metabolism

  Carl R. Flannery;Clare E. Hughes;Barbara L. Schumacher;Debbie Tudor

  513
  Citations

• Mechanisms involved in cartilage proteoglycan catabolism.

  Bruce Caterson;Carl R. Flannery;Clare Elizabeth Hughes;Chris B. Little

  403
  Citations

• n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation *

  Clare L. Curtis;Clare Elizabeth Hughes;C. R. Flannery;Chris B. Little

  382
  Citations

• The role of human HtrA1 in arthritic disease.

  Sandra Grau;Peter J. Richards;Briedgeen Kerr;Clare Elizabeth Hughes

  327
  Citations

• Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

  C E Hughes;B Caterson;A J Fosang;P J Roughley

  327
  Citations

• Proteolytic Activities of Human ADAMTS-5 COMPARATIVE STUDIES WITH ADAMTS-4

  Christi Gendron;Masahide Kashiwagi;Ngee Han Lim;Jan J. Enghild

  311
  Citations

• Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints.

  Barbara L. Schumacher;Clare E. Hughes;Klaus E. Kuettner;Bruce Caterson

  302
  Citations

• Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

  Masahide Kashiwagi;Jan J. Enghild;Christi Gendron;Clare Hughes

  263
  Citations

• Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

  Chris B. Little;Carl R. Flannery;Clare E. Hughes;John S. Mort

  259
  Citations

• Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

  Clare L. Curtis;Sarah G. Rees;Chris B. Little;Carl R. Flannery

  244
  Citations

• The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.

  Jan Bondeson;Shane Daniel Wainwright;Clare Elizabeth Hughes;Bruce Caterson

  234
  Citations

• Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

  Elizabeth C. Arner;Clare E. Hughes;Carl P. Decicco;Bruce Caterson

  191
  Citations

• Binding and localization of recombinant lubricin to articular cartilage surfaces

  Aled R.C. Jones;Jason P. Gleghorn;Clare Elizabeth Hughes;Lori J. Fitz

  188
  Citations

• Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon.

  Sarah Geraldine Rees;Janet Rosemary Davies;Debbie Tudor;Carl Ralph Flannery

  180
  Citations

• Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.

  Z. Zainal;Andrea Jane Longman;S. Hurst;K. Duggan

  179
  Citations

• Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.

  Christopher B. Little;Clare Elizabeth Hughes;Clare L. Curtis;Mike J. Janusz

  176
  Citations

• Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

  A J Fosang;P J Neame;G Murphy

  173
  Citations

• Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. Vol. 279 (2004) 10109-10119

  Masahide Kashiwagi;Jan J. Enghild;Christi Gendron;Clare Hughes

  2
  Citations