World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
51
Citations
7070
World Ranking
5615
National Ranking
330

Overview

Philippe Sarret is affiliated with the Université de Sherbrooke in Canada and has contributed extensively to fields that include Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their research encompasses various subfields such as Cellular and Molecular Neuroscience, Molecular Biology, Physiology, Pharmacology, and Surgery.

Their primary research topics involve Neuropeptides and Animal Physiology, Receptor Mechanisms and Signaling, Pain Mechanisms and Treatments, Apelin-related biomedical research, Cardiovascular, Neuropeptides, and Oxidative Stress Research, Chemical Synthesis and Analysis, and Nuclear Receptors and Signaling.

Philippe Sarret has collaborated frequently with several co-authors, including:

  • Jean-Michel Longpré (29 collaborations)
  • Jérôme Côté (20 collaborations)
  • Rebecca L. Brouillette (16 collaborations)
  • Élie Besserer-Offroy (16 collaborations)
  • Éric Marsault (16 collaborations)

Their publications have appeared in key scientific venues, most notably:

  • Journal of Medicinal Chemistry (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Pharmacological Research (4 publications)
  • Biomedicine & Pharmacotherapy (2 publications)
  • International Journal of Molecular Sciences (2 publications)

Selected recent papers include:

  • "Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity," 2021, Journal of Neuroinflammation
  • "Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease," 2021, Proceedings of the National Academy of Sciences
  • "Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner," 2020, Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • "Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region," 2021, Frontiers in Neural Circuits
  • "Structural insight into apelin receptor-G protein stoichiometry," 2022, Nature Structural & Molecular Biology

Best Publications

  • Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.

    Jean Mazella;Jean-Marie Botto;Eric Guillemare;Thierry Coppola

  • CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury

    Juliette Van Steenwinckel;Annabelle Reaux-Le Goazigo;Blandine Pommier;Annie Mauborgne

  • Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats

    Marc-André Dansereau;Romain-Daniel Gosselin;Michel Pohl;Blandine Pommier

  • Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system

    Philippe Sarret;Pascale Krzywkowski;Laura Segal;Morten S. Nielsen

  • Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin

    Isabelle Dubuc;Philippe Sarret;Catherine Labbé-Jullié;Jean-Marie Botto

  • Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain.

    Alexandre J. Parent;Nicolas Beaudet;Hélène Beaudry;Jenny Bergeron

  • Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications.

    David André Barrière;Christophe Noll;Geneviève Roussy;Farah Lizotte

  • Neurochemokines: a menage a trois providing new insights on the functions of chemokines in the central nervous system.

    William Rostène;Marc-André Dansereau;David Godefroy;Juliette Van Steenwinckel

  • Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: A novel animal model for cerebral palsy in very premature infants

    Sylvie Girard;Hazim Kadhim;Nicolas Beaudet;Philippe Sarret

  • Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system.

    Philippe Sarret;Amélie Perron;Thomas Stroh;Alain Beaudet

  • Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions

    Alexandre Murza;Xavier Sainsily;David Coquerel;Jérôme Côté

  • Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

    Michel Demeule;Nicolas Beaudet;Anthony Régina;Élie Besserer-Offroy

  • Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

    Sylvie Girard;Hugues Sébire;Marie-Elsa Brochu;Sinziana Briota

  • Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines.

    Claude Dal Farra;Philippe Sarret;Valérie Navarro;Jean‐Marie Botto

  • Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

    Tobias Claff;Tobias Claff;Jing Yu;Véronique Blais;Nilkanth Patel

  • The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a Gβγ-Dependent Mechanism

    Mounir Belkouch;Marc-André Dansereau;Annabelle Réaux-Le Goazigo;Juliette Van Steenwinckel

  • Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats.

    Pascal Tétreault;Marc-André Dansereau;Louis Doré-Savard;Nicolas Beaudet

  • Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

    Aleksandra Luginina;Anastasiia Gusach;Egor Marin;Alexey Mishin

  • Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

    Alexandre Murza;Alexandre Parent;Elie Besserer-Offroy;Hugo Tremblay

  • Chemokine network in the nervous system: a new target for pain relief.

    R. D. Gosselin;M. A. Dansereau;M. Pohl;P. Kitabgi

  • Stable Expression of the Mouse Levocabastine-Sensitive Neurotensin Receptor in HEK 293 Cell Line: Binding Properties, Photoaffinity Labeling, and Internalization Mechanism☆

    Jean-Marie Botto;Joëlle Chabry;Philippe Sarret;Jean-Pierre Vincent

Frequent Co-Authors

Martin Lepage
Martin Lepage Douglas Mental Health University Institute
Serge Marchand
Serge Marchand Université de Sherbrooke
William Rostène
William Rostène Institut de la Vision
Klaus H. Kaestner
Klaus H. Kaestner University of Pennsylvania
Johanne Martel-Pelletier
Johanne Martel-Pelletier University of Montreal
Guy Drolet
Guy Drolet Université Laval

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