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Jacek Majewski

Jacek Majewski

D-Index & Metrics

Genetics

D-Index
101
Citations
35949
World Ranking
728
National Ranking
22

Overview

Jacek Majewski is affiliated with McGill University in Canada and has contributed to multiple areas within biochemistry, genetics, molecular biology, and medicine. Their research spans a wide range of topics centered on molecular biology and genetics with notable attention to cancer research and pediatric health.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, specific subfields of focus consist of:

  • Molecular Biology
  • Genetics
  • Pediatrics, Perinatology and Child Health
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Majewski's work addresses several main topics, such as:

  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • Cancer-related gene regulation
  • RNA Research and Splicing
  • Glioma Diagnosis and Treatment
  • Prenatal Screening and Diagnostics

Their recent papers include:

  • H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation, 2020, Cell Reports
  • Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands, 2021, Nature Genetics
  • Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer, 2020, Scientific Reports
  • Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma, 2021, Cell Reports
  • Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas, 2022, Molecular Cell

Frequent co-authors with whom Majewski has collaborated include:

  • Eric Bareke
  • Cynthia Horth
  • Bo Hu
  • Loydie A. Jerome-Majewska
  • Chao Lü

Publication venues where Majewski has frequently published are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Cell Reports
  • Scientific Reports
  • Clinical Genetics

Best Publications

  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Jeremy Schwartzentruber;Andrey Korshunov;Xiao Yang Liu;David T.W. Jones

  • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

    Dominik Sturm;Hendrik Witt;Hendrik Witt;Volker Hovestadt;Dong Anh Khuong-Quang

  • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas.

    Dong Anh Khuong-Quang;Pawel Buczkowicz;Patricia Rakopoulos;Xiao Yang Liu

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov

  • De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

    Jean Baptiste Rivière;Ghayda M. Mirzaa;Brian J. O'Roak;Margaret Beddaoui

  • Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

    Dominik Sturm;Sebastian Bender;David T. W. Jones;Peter Lichter

  • What can exome sequencing do for you

    Jacek Majewski;Jeremy Schwartzentruber;Emilie Lalonde;Alexandre Montpetit

  • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations.

    Xiao-Yang Liu;Noha Gerges;Andrey Korshunov;Nesrin Sabha

  • Clonal selection drives genetic divergence of metastatic medulloblastoma

    Xiaochong Wu;Paul A. Northcott;Adrian Dubuc;Adam J. Dupuy

  • Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

    Leora Witkowski;Jian Carrot-Zhang;Steffen Albrecht;Somayyeh Fahiminiya

  • Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

    Adam M. Fontebasso;Simon Papillon-Cavanagh;Jeremy Schwartzentruber;Hamid Nikbakht

  • An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

    Catherine A. Brownstein;Alan H. Beggs;Nils Homer;Barry Merriman

  • The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

    Daniel N. Weinberg;Simon Papillon-Cavanagh;Haifen Chen;Yuan Yue

  • Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

    Chao Lu;Siddhant U. Jain;Dominik Hoelper;Denise Bechet

  • Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care.

    S L Sawyer;T Hartley;D A Dyment;C L Beaulieu

  • Distribution and Characterization of Regulatory Elements in the Human Genome

    Jacek Majewski;Jurg Ott

  • Genome-wide analysis of transcript isoform variation in humans

    Tony Kwan;David Benovoy;Christel Dias;Scott Gurd

  • Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

    Adam M. Fontebasso;Jeremy Schwartzentruber;Dong Anh Khuong-Quang;Xiao Yang Liu

  • Meta-analysis of genome scans of age-related macular degeneration

    Sheila A. Fisher;Goncalo R. Abecasis;Beverly M. Yashar;Sepideh Zareparsi

  • Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

    Sarah L Sawyer;Lei Tian;Marketta Kähkönen;Jeremy Schwartzentruber

Frequent Co-Authors

Jeremy Schwartzentruber
Jeremy Schwartzentruber Wellcome Sanger Institute
Kym M. Boycott
Kym M. Boycott Children's Hospital of Eastern Ontario
Nada Jabado
Nada Jabado McGill University
Dennis E. Bulman
Dennis E. Bulman Children's Hospital of Eastern Ontario
William D. Foulkes
William D. Foulkes McGill University
David A. Dyment
David A. Dyment University of Ottawa
Jurg Ott
Jurg Ott Rockefeller University
A. Micheil Innes
A. Micheil Innes University of Calgary
Eric A. Shoubridge
Eric A. Shoubridge Montreal Neurological Institute and Hospital
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center

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