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David A. Dyment

David A. Dyment

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
15599
World Ranking
7836
National Ranking
269

Overview

David A. Dyment is a researcher affiliated with the University of Ottawa in Canada. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Genetics, Molecular Biology, and related biomedical subfields. Their publication record demonstrates engagement with diverse domains such as Neurology, Cellular and Molecular Neuroscience, and Pulmonary and Respiratory Medicine.

The scientific topics in Dyment's research include:

  • Genomics and Rare Diseases
  • Genetics and Neurodevelopmental Disorders
  • Genomic variations and chromosomal abnormalities
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Mitochondrial Function and Pathology

Dyment has contributed to several peer-reviewed journals, notably publishing frequently in:

  • The American Journal of Human Genetics
  • American Journal of Medical Genetics Part A
  • Genetics in Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology Genetics

Collaborations exist with multiple researchers, including Kym M. Boycott, Taila Hartley, Kristin D. Kernohan, A. Micheil Innes, and Laurence Faivre. These frequent coauthors reflect intersecting research interests and sustained academic partnerships.

Recent papers authored or co-authored by Dyment encompass a range of topics within genetics and neurodevelopmental research. Examples include:

  • "Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders" (2021) published in Human Genetics and Genomics Advances
  • "Germline AGO2 mutations impair RNA interference and human neurological development" (2020) published in Nature Communications
  • "Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A" (2021) published in The Journal of Experimental Medicine
  • "Functional correlation of genome-wide DNA methylation profiles in genetic neurodevelopmental disorders" (2022) published in Human Mutation
  • "Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction" (2021) published in The American Journal of Human Genetics

Best Publications

  • Genetics of multiple sclerosis

    David A Dyment;George C Ebers;A Dessa Sadovnick

  • Twin concordance and sibling recurrence rates in multiple sclerosis

    C. J. Willer;D. A. Dyment;N. J. Risch;A. D. Sadovnick

  • Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

    Sreeram V. Ramagopalan;Narelle J. Maugeri;Lahiru Handunnetthi;Lahiru Handunnetthi;Matthew R. Lincoln;Matthew R. Lincoln

  • Timing of birth and risk of multiple sclerosis: population based study

    C J Willer;D A Dyment;A D Sadovnick;P M Rothwell

  • Evidence for genetic basis of multiple sclerosis

    A D Sadovnick;G C Ebers;D A Dyment;N J Risch

  • Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care.

    S L Sawyer;T Hartley;D A Dyment;C L Beaulieu

  • A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

    Matthew R Lincoln;Alexandre Montpetit;Alexandre Montpetit;M Zameel Cader;M Zameel Cader;Janna Saarela

  • Parent-of-origin effect in multiple sclerosis: observations in half-siblings

    G C Ebers;G C Ebers;A D Sadovnick;D A Dyment;I M L Yee

  • Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

    Sarah L Sawyer;Lei Tian;Marketta Kähkönen;Jeremy Schwartzentruber

  • Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance

    David A. Dyment;Blanca M. Herrera;M. Zameel Cader;Cristen J. Willer

  • FORGE Canada Consortium: Outcomes of a 2-Year National Rare-Disease Gene-Discovery Project

    Chandree L. Beaulieu;Jacek Majewski;Jeremy Schwartzentruber;Mark E. Samuels

  • Rare variants in the CYP27B1 gene are associated with multiple sclerosis.

    Sreeram V. Ramagopalan;Sreeram V. Ramagopalan;David A. Dyment;M. Zameel Cader;Katie M. Morrison;Katie M. Morrison

  • Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

    Laure Frésard;Craig Smail;Nicole M. Ferraro;Nicole A. Teran

  • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

    Vincenzo Salpietro;Vincenzo Salpietro;Vincenzo Salpietro;Christine L Dixon;Hui Guo;Hui Guo;Oscar D Bello

  • Genetics of Multiple Sclerosis

    David A. Dyment;A. Dessa Sadnovich;George C. Ebers

  • Monogenic variants in dystonia: an exome-wide sequencing study.

    Michael Zech;Robert Jech;Sylvia Boesch;Matej Škorvánek

  • The inheritance of resistance alleles in multiple sclerosis.

    S V Ramagopalan;A P Morris;D A Dyment;D A Dyment;B M Herrera;B M Herrera

  • Autoimmune disease in families with multiple sclerosis: a population-based study

    Sreeram Varadharajan Ramagopalan;Sreeram Varadharajan Ramagopalan;David Alexandre Dyment;David Alexandre Dyment;William Valdar;Blanca Marcela Herrera;Blanca Marcela Herrera

  • Mutations in PIK3R1 Cause SHORT Syndrome

    David A. Dyment;Amanda C. Smith;Diana Alcantara;Jeremy A. Schwartzentruber

  • Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

    Frank J. Kaiser;Morad Ansari;Diana Braunholz;María Concepción Gil-Rodríguez;María Concepción Gil-Rodríguez

Frequent Co-Authors

George C. Ebers
George C. Ebers University of Oxford
Sreeram V. Ramagopalan
Sreeram V. Ramagopalan University of Oxford
Kym M. Boycott
Kym M. Boycott Children's Hospital of Eastern Ontario
Jacek Majewski
Jacek Majewski McGill University
A. Micheil Innes
A. Micheil Innes University of Calgary
Dennis E. Bulman
Dennis E. Bulman Children's Hospital of Eastern Ontario
Cristen J. Willer
Cristen J. Willer University of Michigan–Ann Arbor
Neil Risch
Neil Risch University of California, San Francisco
Jeremy Schwartzentruber
Jeremy Schwartzentruber Wellcome Sanger Institute
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital

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