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Immunology

D-Index
46
Citations
8747
World Ranking
4608
National Ranking
2076

Overview

Charles E. Egwuagu is affiliated with the National Eye Institute in the United States and focuses on the study of immunology, ophthalmology, and related biomedical fields. Their research portfolio spans multiple interconnected disciplines, particularly in immunology and microbiology as well as medicine.

Their scientific contributions address key topics such as:

  • Immunotherapy and immune responses
  • Ocular diseases and Behçet's syndrome
  • Systemic lupus erythematosus research
  • T-cell and B-cell immunology
  • Cytokine signaling pathways and interactions
  • Interferon and immune responses
  • Psoriasis: treatment and pathogenesis

Egwuagu's frequent publication venues include:

  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Proceedings of the National Academy of Sciences
  • Journal of Molecular Biology
  • Scientific Reports

Among recent papers authored or co-authored by Egwuagu are:

  • "Uveitis: Molecular Pathogenesis and Emerging Therapies," 2021, Frontiers in Immunology
  • "Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis," 2020, Frontiers in Immunology
  • "IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases," 2021, Proceedings of the National Academy of Sciences
  • "Interleukin 35 Regulatory B Cells," 2020, Journal of Molecular Biology
  • "STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs," 2020, Scientific Reports

Egwuagu frequently collaborates with other researchers in their field. Notable co-authors include:

  • Jin Kyeong Choi
  • Cheng-Rong Yu
  • Evaristus C. Mbanefo
  • Min-Kyung Kang
  • Manoj Kumar Yadav

The scope of Egwuagu's work contributes to a better understanding of immune mechanisms underlying ocular and systemic autoimmune diseases, with emphasis on cytokine signaling and regulatory functions of immune cells. The research supports multidisciplinary approaches drawn from immunology, ophthalmology, molecular biology, rheumatology, and oncology.

Best Publications

  • TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1

    Ahjoku Amadi-Obi;Cheng-Rong Yu;Xuebin Liu;Rashid M Mahdi

  • Interleukin-35 induces regulatory B cells that suppress autoimmune disease.

    Ren-Xi Wang;Cheng-Rong Yu;Ivy M Dambuza;Rashid M Mahdi

  • Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance

    Charles E. Egwuagu;Cheng-Rong Yu;Meifen Zhang;Rashid M. Mahdi

  • Loss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases

    Xuebin Liu;Yun Sang Lee;Cheng-Rong Yu;Charles E. Egwuagu

  • STAT3 in CD4+ T helper Cell differentiation and Inflammatory Diseases

    Charles E. Egwuagu

  • Thymic expression of autoantigens correlates with resistance to autoimmune disease.

    C E Egwuagu;P Charukamnoetkanok;I Gery

  • Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease

    Lin Sun;Chang He;Lekha Nair;Justine Yeung

  • Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling.

    Sharon H. Jackson;Cheng-Rong Yu;Rashid M. Mahdi;Samuel Ebong

  • IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.

    Ivy M. Dambuza;Chang He;Chang He;Jin Kyeong Choi;Cheng-Rong Yu

  • A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

    Xiaoqian Wang;Yinxiang Wei;He Xiao;Xiaoling Liu

  • Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception

    Nicolas Vogel;Michael Kirisits;Eric Michael;Howard Bach

  • Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells.

    Cheng-Rong Yu;Rashid M. Mahdi;Samuel Ebong;Barbara P. Vistica

  • STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+ T Cells

    Hyun-Mee Oh;Cheng-Rong Yu;Ivy Dambuza;Bernadette Marrero

  • STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors

    Hyun-Mee Oh;Cheng-Rong Yu;Nady Golestaneh;Ahjoku Amadi-Obi

  • Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.

    Charles E. Egwuagu;Cheng-Rong Yu;Lin Sun;Renxi Wang

  • Novel IL27p28/IL12p40 Cytokine Suppressed Experimental Autoimmune Uveitis by Inhibiting Autoreactive Th1/Th17 Cells and Promoting Expansion of Regulatory T Cells

    Ren-Xi Wang;Cheng-Rong Yu;Rashid M. Mahdi;Charles E. Egwuagu

  • Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10.

    Yun Sang Lee;Ahjoku Amadi-Obi;Cheng-Rong Yu;Charles E Egwuagu

  • STAT3 Activates miR-155 in Th17 Cells and Acts in Concert to Promote Experimental Autoimmune Uveitis

    Thelma Escobar;Cheng-Rong Yu;Stefan A. Muljo;Charles E. Egwuagu

  • Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.

    Cheng-Rong Yu;Rashid M. Mahdi;Samuel Ebong;Barbara P. Vistica

  • Autoreactive Memory CD4+ T Lymphocytes that mediate Chronic Uveitis Reside in the Bone Marrow through STAT3-dependent Mechanisms

    Hyun-Mee Oh;Cheng-Rong Yu;YongJun Lee;Chi-Chao Chan

  • Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals

    Hiroshi Takase;Cheng Rong Yu;Rashid M. Mahdi;Daniel C. Douek

Frequent Co-Authors

Igal Gery
Igal Gery National Institutes of Health
Chi-Chao Chan
Chi-Chao Chan National Institutes of Health
Rachel R. Caspi
Rachel R. Caspi National Institutes of Health
Robert B. Nussenblatt
Robert B. Nussenblatt National Institutes of Health
Eric F. Wawrousek
Eric F. Wawrousek National Institutes of Health
Eddie Reed
Eddie Reed National Institutes of Health
Paul T. Wingfield
Paul T. Wingfield National Institutes of Health
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Robert N. Fariss
Robert N. Fariss National Institutes of Health
Jun Chen
Jun Chen Sun Yat-sen University

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