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Immunology

D-Index
84
Citations
22535
World Ranking
1396
National Ranking
712

Medicine

D-Index
84
Citations
22535
World Ranking
15242
National Ranking
7688

Overview

Rachel R. Caspi is a researcher affiliated with the National Institutes of Health in the United States. Their academic work primarily focuses on the intersection of immunology, ophthalmology, and molecular biology, with additional research contributions in epidemiology and rheumatology.

The scientist's main fields of study include Medicine and Immunology and Microbiology. Their subfields of expertise span Immunology, Ophthalmology, Molecular Biology, Epidemiology, and Rheumatology. The primary research topics covered by their work are:

  • Ocular Diseases and Behçet's Syndrome
  • Psoriasis: Treatment and Pathogenesis
  • T-cell and B-cell Immunology
  • Cytomegalovirus and herpesvirus research
  • Ocular Surface and Contact Lens
  • Ocular Infections and Treatments
  • Systemic Lupus Erythematosus Research

Recent publications by Rachel R. Caspi highlight ongoing investigations into immune system mechanisms and ocular immunology. Notable papers include:

  • "The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24" (2020, Immunity)
  • "Mucosal immunology of the ocular surface" (2022, Mucosal Immunology)
  • "IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases" (2021, Proceedings of the National Academy of Sciences)
  • "Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome" (2022, Annals of the Rheumatic Diseases)
  • "T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis" (2020, Nature Communications)

Their research has been published extensively in venues such as The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Proceedings of the National Academy of Sciences, and Nature Communications.

Rachel R. Caspi collaborates frequently with other researchers. Some of their most common coauthors are:

  • Mary J. Mattapallil
  • Reiko Horai
  • Vijayaraj Nagarajan
  • Yingyos Jittayasothorn
  • Anthony J. St. Leger

Best Publications

  • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.

    Dror Luger;Phyllis B Silver;Jun Tang;Daniel J. Cua

  • The Rd8 Mutation of the Crb1 Gene Is Present in Vendor Lines of C57BL/6N Mice and Embryonic Stem Cells, and Confounds Ocular Induced Mutant Phenotypes

    Mary J. Mattapallil;Eric F. Wawrousek;Chi-Chao Chan;Hui Zhao

  • Th1 and Th17 cells

    Jesse M. Damsker;Anna M. Hansen;Rachel R. Caspi

  • A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens.

    R. R. Caspi;F. G. Roberge;Chi-Chao Chan;B. Wiggert

  • A look at autoimmunity and inflammation in the eye

    Rachel R. Caspi

  • Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

    Aleksandra V. Rachitskaya;Anna M. Hansen;Reiko Horai;Zhuqing Li

  • Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

    Jun Tang;Ru Zhou;Dror Luger;Wei Zhu

  • T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat.

    R R Caspi;F G Roberge;C G McAllister;M el-Saied

  • Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

    De-Xuan Yang;Qian-Qian Chen;Shao Bo Su;Ping Zhang

  • Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

    Reiko Horai;Carlos R. Zárate-Bladés;Patricia Dillenburg-Pilla;Jun Chen;Jun Chen

  • Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

    R B Nussenblatt;R R Caspi;R Mahdi;C C Chan

  • Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

    Jason DeVoss;Yafei Hou;Kellsey Johannes;Wen Lu

  • Rodent models of experimental autoimmune uveitis.

    Rajeev K Agarwal;Phyllis B Silver;Rachel R Caspi

  • Ocular immune privilege.

    Ru Zhou;Rachel R Caspi

  • Experimental autoimmune uveoretinitis in the rat and mouse.

    Rachel R. Caspi

  • An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells

    Anthony J. St. Leger;Jigar V. Desai;Rebecca A. Drummond;Abirami Kugadas

  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

    Teresa K. Tarrant;Phyllis B. Silver;Jennifer L. Wahlsten;Luiz Vicente Rizzo

  • Cytokines in autoimmune uveitis.

    Reiko Horai;Rachel R. Caspi

  • IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.

    Leslie S. Jones;Luiz V. Rizzo;Rajeev K. Agarwal;Teresa K. Tarrant

  • Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

    RR Caspi;CC Chan;BG Grubbs;PB Silver

  • A new immunomodulating compound (AS-101) with potential therapeutic application

    B. Sredni;R. R. Caspi;A. Klein;Y. Kalechman

Frequent Co-Authors

Phyllis B. Silver
Phyllis B. Silver National Institutes of Health
Chi-Chao Chan
Chi-Chao Chan National Institutes of Health
Reiko Horai
Reiko Horai National Eye Institute
Barbara Wiggert
Barbara Wiggert National Institutes of Health
Robert B. Nussenblatt
Robert B. Nussenblatt National Institutes of Health
Igal Gery
Igal Gery National Institutes of Health
Yoichiro Iwakura
Yoichiro Iwakura Tokyo University of Science
Ronald L. Wilder
Ronald L. Wilder National Institutes of Health
Charles E. Egwuagu
Charles E. Egwuagu National Eye Institute
Eric F. Wawrousek
Eric F. Wawrousek National Institutes of Health

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