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Immunology

D-Index
44
Citations
7225
World Ranking
4790
National Ranking
2148

Overview

Phyllis B. Silver is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in immunology and microbiology, with a strong focus on medicine. Their scholarly output includes work spanning immunology, ophthalmology, molecular biology, rheumatology, and applied microbiology and biotechnology.

The main topics addressed in Silver's research include:

  • Psoriasis: Treatment and Pathogenesis
  • Ocular Diseases and Behçet's Syndrome
  • Mast cells and histamine
  • Immunodeficiency and Autoimmune Disorders
  • Antibiotic Use and Resistance
  • Nosocomial Infections in ICU
  • Antibiotics Pharmacokinetics and Efficacy

Notable recent publications by Silver consist of:

  • The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24, 2020, Immunity
  • Opportunities to Improve Antibiotic Appropriateness in U.S. ICUs: A Multicenter Evaluation, 2020, Critical Care Medicine
  • Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation, 2020, Journal of Autoimmunity
  • Draft Reference Genome Sequence of Corynebacterium mastitidis RC, an Ocular Commensal, Isolated from Mouse Conjunctiva, 2022, Microbiology Resource Announcements
  • A novel self-regulatory mechanism of Th17 cells controls autoimmune uveitis through interleukin-24, 2020, The Journal of Immunology

Silver frequently collaborates with a group of researchers, including:

  • Rachel R Caspi
  • Chi-Chao Chan
  • Mary J. Mattapallil
  • So Jin Bing
  • Yingyos Jittayasothorn

The primary journals in which Silver has published multiple works include:

  • The Journal of Immunology
  • Immunity
  • Critical Care Medicine
  • Journal of Autoimmunity
  • Microbiology Resource Announcements

The research focuses on advanced immunological mechanisms, including the role of cytokines like IL-17A and IL-24 in immune regulation and autoimmune pathologies. Silver's work also extends to clinical concerns such as antibiotic stewardship in intensive care units, highlighting intersections between immunology and applied medical practice.

Best Publications

  • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.

    Dror Luger;Phyllis B Silver;Jun Tang;Daniel J. Cua

  • Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

    Jun Tang;Ru Zhou;Dror Luger;Wei Zhu

  • Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

    Reiko Horai;Carlos R. Zárate-Bladés;Patricia Dillenburg-Pilla;Jun Chen;Jun Chen

  • Rodent models of experimental autoimmune uveitis.

    Rajeev K Agarwal;Phyllis B Silver;Rachel R Caspi

  • An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells

    Anthony J. St. Leger;Jigar V. Desai;Rebecca A. Drummond;Abirami Kugadas

  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

    Teresa K. Tarrant;Phyllis B. Silver;Jennifer L. Wahlsten;Luiz Vicente Rizzo

  • Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

    RR Caspi;CC Chan;BG Grubbs;PB Silver

  • Essential Role of the MyD88 Pathway, but Nonessential Roles of TLRs 2, 4, and 9, in the Adjuvant Effect Promoting Th1-Mediated Autoimmunity

    Shao Bo Su;Phyllis B. Silver;Rafael S. Grajewski;Rajeev K. Agarwal

  • Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response.

    R R Caspi;P B Silver;C C Chan;B Sun

  • Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype.

    Dody Avichezer;Phyllis B. Silver;Chi-Chao Chan;Barbara Wiggert

  • The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.

    Wai Po Chong;Wai Po Chong;Mary J. Mattapallil;Kumarkrishna Raychaudhuri;So Jin Bing

  • Mouse Models of Experimental Autoimmune Uveitis

    Rachel R. Caspi;Phyllis B. Silver;Dror Luger;Jun Tang

  • Endogenous IL-12 Is Required for Induction and Expression of Experimental Autoimmune Uveitis

    Teresa K. Tarrant;Phyllis B. Silver;Chi Chao Chan;Barbara Wiggert

  • Autoimmune Uveitis Elicited with Antigen-Pulsed Dendritic Cells Has a Distinct Clinical Signature and Is Driven by Unique Effector Mechanisms: Initial Encounter with Autoantigen Defines Disease Phenotype

    Jun Tang;Wei Zhu;Phyllis B. Silver;Shao Bo Su

  • The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.

    Phyllis B. Silver;Chi-Chao Chan;Barbara Wiggert;Rachel R. Caspi

  • Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype

    P. B. Silver;L. V. Rizzo;Chi-Chao Chan;L. A. Donoso

  • Anti-tumor necrosis factor alpha therapy suppresses the induction of experimental autoimmune uveoretinitis in mice by inhibiting antigen priming.

    Gil Sartani;Phyllis B. Silver;Luiz V. Rizzo;Chi-Chao Chan

  • Uveitogenicity Is Associated with a Th1-like Lymphokine Profile: Cytokine-Dependent Modulation of Early and Committed Effector T Cells in Experimental Autoimmune Uveitis

    Hui Xu;Luiz V. Rizzo;Phyllis B. Silver;Rachel R. Caspi

  • Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity

    Rafael S. Grajewski;Phyllis B. Silver;Rajeev K. Agarwal;Shao Bo Su

  • Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice.

    L. V. Rizzo;P. Silver;B. Wiggert;F. Hakim

  • An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms.

    Dody Avichezer;Rafael S. Grajewski;Chi Chao Chan;Mary J. Mattapallil

Frequent Co-Authors

Rachel R. Caspi
Rachel R. Caspi National Institutes of Health
Chi-Chao Chan
Chi-Chao Chan National Institutes of Health
Reiko Horai
Reiko Horai National Eye Institute
Daniel J. Cua
Daniel J. Cua Johnson & Johnson (United States)
Barbara Wiggert
Barbara Wiggert National Institutes of Health
Yoichiro Iwakura
Yoichiro Iwakura Tokyo University of Science
Robert A. Kastelein
Robert A. Kastelein MSD (United States)
Mitchell Kronenberg
Mitchell Kronenberg University of California, San Diego
Michael A. Kaliner
Michael A. Kaliner National Institutes of Health
Ronald L. Wilder
Ronald L. Wilder National Institutes of Health

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