World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
48
Citations
11386
World Ranking
4401
National Ranking
1997

Overview

Reiko Horai is affiliated with the National Eye Institute in the United States. Their research primarily focuses on immunology and ophthalmology, intersecting with medicine and microbiology. Horai's work addresses mechanisms of ocular diseases and autoimmune disorders from a cellular and molecular perspective.

Their publications cover various topics including ocular diseases and Behçet's syndrome, psoriasis treatment and pathogenesis, cytomegalovirus and herpesvirus research, immunodeficiency and autoimmune disorders, systemic lupus erythematosus research, interferon and immune responses, and T-cell and B-cell immunology.

Horai has contributed notable papers such as:

  • The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24 (2020, Immunity)
  • T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis (2020, Nature Communications)
  • Microbiota as Drivers and as Therapeutic Targets in Ocular and Tissue Specific Autoimmunity (2021, Frontiers in Cell and Developmental Biology)
  • A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina (2020, eLife)
  • Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation (2020, Journal of Autoimmunity)

Their frequent coauthors include:

  • Rachel R Caspi
  • Mary J. Mattapallil
  • Yingyos Jittayasothorn
  • Vijayaraj Nagarajan
  • So Jin Bing

Horai's research has appeared repeatedly in venues such as The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Immunity, Nature Communications, and Frontiers in Cell and Developmental Biology. The Journal of Immunology and bioRxiv represent the most common platforms for their work.

The main fields of study associated with Horai's publications include Medicine and Immunology and Microbiology. Within these, their work often focuses on subfields like Immunology, Ophthalmology, Epidemiology, Molecular Biology, and Rheumatology.

Best Publications

  • Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

    Reiko Horai;Shinobu Saijo;Hidetoshi Tanioka;Susumu Nakae

  • Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

    Reiko Horai;Masahide Asano;Katsuko Sudo;Hirotaka Kanuka

  • IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

    Susumu Nakae;Shinobu Saijo;Reiko Horai;Katsuko Sudo

  • Role of IL-1alpha and IL-1beta in ischemic brain damage.

    H. Boutin;R. A. LeFeuvre;R. Horai;M. Asano

  • Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

    Keiko Miwa;Masahide Asano;Reiko Horai;Yoichiro Iwakura

  • Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

    Aleksandra V. Rachitskaya;Anna M. Hansen;Reiko Horai;Zhuqing Li

  • Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

    Reiko Horai;Carlos R. Zárate-Bladés;Patricia Dillenburg-Pilla;Jun Chen;Jun Chen

  • IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions

    Taizo Matsuki;Reiko Horai;Katsuko Sudo;Yoichiro Iwakura

  • Protective Role of Interleukin-1 in Mycobacterial Infection in IL-1 α/β Double-Knockout Mice

    Hiroyuki Yamada;Satoru Mizumo;Reiko Horai;Yoichiro Iwakura

  • Cytokines in autoimmune uveitis.

    Reiko Horai;Rachel R. Caspi

  • Altered Development of CD8+ T Cell Lineages in Mice Deficient for the Tec Kinases Itk and Rlk

    Christine Broussard;Christine Fleischacker;Reiko Horai;Madeva Chetana

  • Interleukin‐1β, but not interleukin‐1α, is required for T‐cell‐dependent antibody production

    Susumu Nakae;Masahide Asano;Masahide Asano;Reiko Horai;Yoichiro Iwakura

  • SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation

    Jennifer L. Cannons;Li J. Yu;Dragana Jankovic;Shane Crotty

  • IL‐1 is required for allergen‐specific Th2 cell activation and the development of airway hypersensitivity response

    Susumu Nakae;Yutaka Komiyama;Hiroshi Yokoyama;Aya Nambu

  • Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis

    Taizo Matsuki;Susumu Nakae;Katsuko Sudo;Reiko Horai

  • Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

    Julie A. Readinger;Kristen L. Mueller;Ana M. Venegas;Reiko Horai

  • TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

    Reiko Horai;Akiko Nakajima;Katsuyoshi Habiro;Motoko Kotani

  • IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells

    Susumu Nakae;Masahide Asano;Reiko Horai;Nobuo Sakaguchi

  • NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.

    Takanobu Nakazawa;Shoji Komai;Ayako M Watabe;Yuji Kiyama

  • The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.

    Wai Po Chong;Wai Po Chong;Mary J. Mattapallil;Kumarkrishna Raychaudhuri;So Jin Bing

  • Deficiency of Interleukin-1 Receptor Antagonist Promotes Neointimal Formation After Injury

    Kikuo Isoda;Masaru Shiigai;Norio Ishigami;Taizo Matsuki

  • Requirements for selection of conventional and innate T lymphocyte lineages.

    Reiko Horai;Kristen L. Mueller;Robin A. Handon;Jennifer L. Cannons

Frequent Co-Authors

Rachel R. Caspi
Rachel R. Caspi National Institutes of Health
Phyllis B. Silver
Phyllis B. Silver National Institutes of Health
Chi-Chao Chan
Chi-Chao Chan National Institutes of Health
Pamela L. Schwartzberg
Pamela L. Schwartzberg National Institutes of Health
Jun Chen
Jun Chen Sun Yat-sen University
Stacie M. Anderson
Stacie M. Anderson National Institutes of Health
Martha Kirby
Martha Kirby National Institutes of Health
Kenya Honda
Kenya Honda Keio University
Joseph F. Petrosino
Joseph F. Petrosino Baylor College of Medicine
Nadim J. Ajami
Nadim J. Ajami The University of Texas MD Anderson Cancer Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Immunology, pursuing a related nursing degree can open diverse career opportunities in healthcare and research. Many professionals start with foundational programs such as online absn programs for non nurses, which offer a flexible path for those transitioning into nursing from other fields.

Once a Bachelor of Science in Nursing is earned, accelerated options like accelerated bsn programs for non nurses allow faster entry into advanced nursing roles. These programs help build essential clinical skills that are critical for immunology-related careers.

For those already licensed as Family Nurse Practitioners (FNPs), bridging into specialized areas is also possible. A dedicated fnp to acute care np bridge program is designed to expand expertise and clinical scope, ideal for immunology practitioners managing acute patient cases.

Additionally, accelerated FNP programs can further enhance qualifications with a faster route to advanced practice. The accelerated fnp program offers flexible learning tailored to busy professionals aiming to advance their careers in immunology-focused healthcare settings.

Best Scientists Citing Reiko Horai

Trending Scientists