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Biology and Biochemistry

D-Index
66
Citations
11409
World Ranking
8895
National Ranking
681

Overview

Heping Xu is affiliated with Queen's University Belfast in the United Kingdom, with a primary focus on the field of Medicine. Their research encompasses multiple subfields, notably Ophthalmology, Molecular Biology, Immunology, Radiology, Nuclear Medicine and Imaging, and Neurology.

Their research mainly addresses several interconnected topics, including:

  • Retinal Diseases and Treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Retinal and Optic Conditions
  • Ocular Diseases and Behçet's Syndrome
  • Retinal Imaging and Analysis
  • Glaucoma and retinal disorders
  • Retinal Development and Disorders

Heping Xu has contributed extensively to scientific literature, with recent papers that reflect ongoing investigations into retinal and neuroinflammatory processes. Notable recent publications include:

  • "Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration," 2020, Journal of Neuroinflammation
  • "Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis," 2021, Theranostics
  • "Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis," 2022, Journal of Neuroinflammation
  • "Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells," 2022, Journal of Neuroinflammation
  • "Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration," 2022, Journal of Neuroinflammation

Their frequent collaborators include:

  • Mei Chen
  • Jinyan Qi
  • Caijiao Yi
  • María Llorián-Salvador
  • Hua Yan

Heping Xu's research findings are regularly published in journals with a strong focus on eye and neurological sciences. The venues where they publish most often are:

  • Investigative Ophthalmology & Visual Science
  • Journal of Neuroinflammation
  • International Journal of Molecular Sciences
  • Frontiers in Ophthalmology
  • Nature Communications

Best Publications

  • Para-inflammation in the aging retina.

    Heping Xu;Mei Chen;John Vincent Forrester

  • Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice.

    Heping Xu;Mei Chen;Ayyakkannu Manivannan;Noemi Lois

  • Parainflammation, chronic inflammation, and age-related macular degeneration

    Mei Chen;Heping Xu

  • Glucose transporter 1 critically controls microglial activation through facilitating glycolysis.

    Luxi Wang;Sofia Pavlou;Xuan Du;Mohajeet Bhuckory

  • Immune regulation in the aging retina.

    Mei Chen;Chang Luo;Jiawu Zhao;Gayathri Devarajan

  • Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments.

    Mei Chen;John Vincent Forrester;Heping Xu

  • Dendritic cell physiology and function in the eye.

    John Vincent Forrester;Heping Xu;Lucia Kuffova;Andrew D. Dick

  • Turnover of resident retinal microglia in the normal adult mouse.

    Heping Xu;Mei Chen;Eric J. Mayer;John V. Forrester

  • Targeting the complement system for the management of retinal inflammatory and degenerative diseases

    Heping Xu;Mei Chen

  • Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

    Sofia Pavlou;Jaime Lindsay;Rebecca Ingram;Heping Xu

  • Leukocyte trafficking in experimental autoimmune uveitis: breakdown of blood-retinal barrier and upregulation of cellular adhesion molecules.

    Heping Xu;John Vincent Forrester;Janet Mary Liversidge;Isabel Joan Crane

  • Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72

    Heping Xu;Tomomi Ito;Akira Tawada;Hiroshi Maeda

  • Immune privilege or privileged immunity

    John Vincent Forrester;Heping Xu;T. Lambe;R. J. Cornall

  • Good news–bad news: the Yin and Yang of immune privilege in the eye

    John Vincent Forrester;Heping Xu

  • Retinal pigment epithelial cell multinucleation in the aging eye – a mechanism to repair damage and maintain homoeostasis

    Mei Chen;Dinusha Rajapakse;Monika Fraczek;Chang Luo

  • A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images

    Heping Xu;Philippe Koch;Mei Chen;Annie Lau

  • Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion

    Heping Xu;Mei Chen;John V. Forrester;Noemi Lois

  • LYVE-1-positive macrophages are present in normal murine eyes.

    Heping Xu;Mei Chen;Delyth Marion Reid;John Vincent Forrester

  • Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.

    Szabolcs Felszeghy;Johanna Viiri;Jussi J. Paterno;Juha M.T. Hyttinen

  • The soluble isoform of CTLA‐4 as a regulator of T‐cell responses

    Frank J Ward;Lekh N Dahal;Subadra K Wijesekera;Sultan K Abdul-Jawad

Frequent Co-Authors

John V. Forrester
John V. Forrester University of Aberdeen
Janet Liversidge
Janet Liversidge University of Aberdeen
Alan W. Stitt
Alan W. Stitt Queen's University Belfast
Usha Chakravarthy
Usha Chakravarthy Queen's University Belfast
Andrew D. Dick
Andrew D. Dick University of Bristol
Kai Kaarniranta
Kai Kaarniranta University of Eastern Finland
Adrien Kissenpfennig
Adrien Kissenpfennig Queen's University Belfast
Arto Urtti
Arto Urtti University of Eastern Finland
Poo Balan Ganesan
Poo Balan Ganesan University of Malaya
David A. Copland
David A. Copland University of Queensland

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