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Biology and Biochemistry

D-Index
72
Citations
24001
World Ranking
6176
National Ranking
2905

Overview

Yuval Kluger is affiliated with Yale University in the United States. Their research primarily focuses on the interface of biochemistry, genetics, molecular biology, and medicine, with a considerable body of work dedicated to molecular biology and immunology. They have contributed extensively to the fields of oncology and cancer research as well.

The scientist's research topics include:

  • Single-cell and spatial transcriptomics
  • Immune cells in cancer
  • Gene expression and cancer classification
  • Cancer immunotherapy and biomarkers
  • Gene regulatory network analysis
  • Bioinformatics and genomic networks
  • Cancer genomics and diagnostics

Frequent co-authors collaborating with Yuval Kluger are:

  • Rihao Qu
  • Richard A. Flavell
  • Jun Zhao
  • Esen Sefik
  • Harriet M. Kluger

The scientist's work is widely published in several scientific venues. The most frequent ones include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • arXiv (Cornell University)
  • Nature
  • Cancer Research
  • Proceedings of the National Academy of Sciences

Selected recent papers authored or co-authored by Yuval Kluger include:

  • "Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial," 2020, The Lancet Oncology
  • "Inflammasome activation in infected macrophages drives COVID-19 pathology," 2022, Nature
  • "Spatial epigenome-transcriptome co-profiling of mammalian tissues," 2023, Nature
  • "Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche," 2020, Nature
  • "Zero-preserving imputation of single-cell RNA-seq data," 2022, Nature Communications

Yuval Kluger's research demonstrates a multidisciplinary approach encompassing experimental and computational biology techniques. Their contribution spans advancing knowledge in molecular mechanisms in cancer biology, transcriptomics technologies, and immune system interactions in disease contexts.

Best Publications

  • A Bayesian networks approach for predicting protein-protein interactions from genomic data.

    Ronald Jansen;Haiyuan Yu;Dov Greenbaum;Yuval Kluger

  • DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network

    Jared L. Katzman;Uri Shaham;Alexander Cloninger;Alexander Cloninger;Jonathan Bates

  • XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks

    Diego Acosta-Alvear;Yiming Zhou;Alexandre Blais;Mary Tsikitis

  • Spectral Biclustering of Microarray Data: Coclustering Genes and Conditions

    Yuval Kluger;Ronen Basri;Joseph T. Chang;Mark Gerstein

  • PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

    Zhonghua Gao;Jin Zhang;Roberto Bonasio;Francesco Strino

  • m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

    Hua-Bing Li;Jiyu Tong;Jiyu Tong;Shu Zhu;Pedro J. Batista

  • An initial blueprint for myogenic differentiation

    Alexandre Blais;Mary Tsikitis;Diego Acosta-Alvear;Roded Sharan

  • KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

    Dietmar Herndler-Brandstetter;Harumichi Ishigame;Ryo Shinnakasu;Valerie Plajer

  • Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data

    George C Linderman;Manas Rachh;Jeremy G Hoskins;Stefan Steinerberger

  • Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial.

    Sarah B Goldberg;Kurt A Schalper;Scott N Gettinger;Amit Mahajan

  • High HSP90 Expression Is Associated with Decreased Survival in Breast Cancer

    Elah Pick;Yuval Kluger;Jennifer M. Giltnane;Christopher Moeder

  • Structural proteomics of an archaeon.

    Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger

  • PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells

    Ruth Halaban;Wengeng Zhang;Antonella Bacchiocchi;Elaine Cheng

  • A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition

    Hugh Cam;Egle Balciunaite;Alexandre Blais;Alexander Spektor

  • DeepSurv: Personalized Treatment Recommender System Using A Cox Proportional Hazards Deep Neural Network

    Jared Katzman;Uri Shaham;Jonathan Bates;Alexander Cloninger

  • Genome-wide remodeling of the epigenetic landscape during myogenic differentiation

    Patrik Asp;Roy Blum;Vasupradha Vethantham;Fabio Parisi;Fabio Parisi

  • Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

    Shu Zhu;Siyuan Ding;Siyuan Ding;Penghua Wang;Zheng Wei

  • Quantum evolution of disoriented chiral condensates

    Fred Cooper;Yuval Kluger;Emil Mottola;Juan Pablo Paz

  • Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial.

    Harriet M. Kluger;Veronica Chiang;Amit Mahajan;Christopher R. Zito

  • SpectralNet: Spectral Clustering using Deep Neural Networks

    Uri Shaham;Kelly P. Stanton;Henry Li;Boaz Nadler

Frequent Co-Authors

Harriet M. Kluger
Harriet M. Kluger Yale University
Richard A. Flavell
Richard A. Flavell Yale University
David L. Rimm
David L. Rimm Yale University
Boaz Nadler
Boaz Nadler Weizmann Institute of Science
Mark Gerstein
Mark Gerstein Yale University
Sherman M. Weissman
Sherman M. Weissman Yale University
Peter E. Newburger
Peter E. Newburger University of Massachusetts Chan Medical School
Jane A. Skok
Jane A. Skok New York University
Ruth Halaban
Ruth Halaban Yale University
Brian David Dynlacht
Brian David Dynlacht New York University

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