World's Best Scientists 2026 revealed!
Christoph A. Sotriffer

Christoph A. Sotriffer

D-Index & Metrics

Chemistry

D-Index
41
Citations
6070
World Ranking
17773
National Ranking
1288

Christoph A. Sotriffer publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Christoph A. Sotriffer sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 149 publications — 14th percentile

14% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Christoph A. Sotriffer D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Christoph A. Sotriffer sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 41 D-Index — 2nd percentile

2% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Christoph A. Sotriffer is affiliated with the University of Würzburg in Germany. Their research spans multiple disciplines within the life sciences, primarily focusing on biochemistry, genetics, and molecular biology, supported by 49 publications in these areas. Medicine is another key field of study, with 28 related publications. The scientist's work extends into several subfields, including molecular biology, materials chemistry, pharmacology, organic chemistry, and cellular and molecular neuroscience.

The main topics addressed in their research include protein structure and dynamics, ubiquitin and proteasome pathways, and computational drug discovery methods. Other notable topics cover protein degradation and inhibitors, multiple myeloma research and treatments, photochromic and fluorescence chemistry, and neuroscience and neuropharmacology research.

Several frequently published venues underline the dissemination of their research findings. These include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ChemMedChem
  • ACS Chemical Neuroscience
  • Molecular Pharmaceutics

Christoph A. Sotriffer has collaborated regularly with several co-authors, including:

  • Josef Kehrein (11 joint publications)
  • Michael Decker (9 joint publications)
  • Mathias Diebold (7 joint publications)
  • Ute A. Hellmich (7 joint publications)
  • Bikash Adhikari (6 joint publications)

Representative recent papers illustrate the diversity and focus of this work. Examples include:

  • "PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase" published in 2020 in Nature Chemical Biology
  • "Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders" published in 2021 in Journal of Medicinal Chemistry
  • "Melatonin receptor ligands: A pharmaco-chemical perspective" published in 2020 in Journal of Pineal Research
  • "Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model" published in 2021 in Journal of Medicinal Chemistry
  • "Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2" published in 2020 in ChemMedChem

Best Publications

  • Discovery of a novel binding trench in HIV integrase.

    Julie R. Schames;Richard H. Henchman;Jay S. Siegel;Christoph A. Sotriffer

  • Target flexibility: an emerging consideration in drug discovery and design.

    Pietro Cozzini;Glen E. Kellogg;Francesca Spyrakis;Donald J. Abraham

  • Structure-Based Search for New Inhibitors of Cholinesterases

    Marek Bajda;Anna Więckowska;Michalina Hebda;Natalia Guzior

  • SFCscore(RF): a random forest-based scoring function for improved affinity prediction of protein-ligand complexes.

    David Zilian;Christoph A. Sotriffer

  • Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase.

    David C Rowley;Mark S.T Hansen;Denise Rhodes;Christoph A Sotriffer

  • PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

    Bikash Adhikari;Jelena Bozilovic;Jelena Bozilovic;Mathias Diebold;Jessica Denise Schwarz

  • Identification and mapping of small-molecule binding sites in proteins: computational tools for structure-based drug design

    Christoph Sotriffer;Gerhard Klebe

  • Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions.

    Holger Steuber;Matthias Zentgraf;Christof Gerlach;Christoph A. Sotriffer

  • SFCscore: scoring functions for affinity prediction of protein-ligand complexes.

    Christoph A. Sotriffer;Paul Sanschagrin;Hans Matter;Gerhard Klebe

  • Docking into knowledge-based potential fields: a comparative evaluation of DrugScore.

    Christoph A. Sotriffer;Holger Gohlke;Gerhard Klebe

  • Active site binding modes of HIV-1 integrase inhibitors.

    Christoph A. Sotriffer;and Haihong Ni;J. Andrew McCammon

  • AffinDB: a freely accessible database of affinities for protein–ligand complexes from the PDB

    Peter Block;Christoph A. Sotriffer;Ingo Dramburg;Gerhard Klebe

  • Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

    Edgar Sawatzky;Sarah Wehle;Beata Kling;Jan Wendrich

  • Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.

    Christoph A. Sotriffer;Oliver Krämer;Gerhard Klebe

  • Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation.

    Xinyu Chen;Sarah Wehle;Natascha Kuzmanovic;Benjamin Merget

  • Automated docking of ligands to antibodies: methods and applications.

    Christoph A. Sotriffer;Wolfgang Flader;Rudolf H. Winger;Bernd M. Rode

  • Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.

    Fouad H. Darras;Steffen Pockes;Guozheng Huang;Sarah Wehle

  • Ordered water and ligand mobility in the HIV-1 integrase-5CITEP complex: a molecular dynamics study.

    Haihong Ni;and Christoph A. Sotriffer;J. Andrew McCammon

  • Protonation Changes upon Ligand Binding to Trypsin and Thrombin: Structural Interpretation Based on pKa Calculations and ITC Experiments

    Paul Czodrowski;Christoph A. Sotriffer;Gerhard Klebe

  • Accounting for Induced-Fit Effects in Docking: What is Possible and What is Not?

    Christoph A. Sotriffer

  • Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.

    Matthias Hoffmann;Carina Stiller;Erik Endres;Matthias Scheiner

  • Physicochemical descriptors to discriminate protein-protein interactions in permanent and transient complexes selected by means of machine learning algorithms.

    Peter Block;Juri Paern;Eyke Hüllermeier;Paul Sanschagrin

Frequent Co-Authors

Gerhard Klebe
Gerhard Klebe Philipp University of Marburg
Ulrike Holzgrabe
Ulrike Holzgrabe University of Würzburg
Caroline Kisker
Caroline Kisker University of Würzburg
Bernd M. Rode
Bernd M. Rode University of Innsbruck
Peter J. Tonge
Peter J. Tonge Stony Brook University
Klaus R. Liedl
Klaus R. Liedl University of Innsbruck
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Tanja Schirmeister
Tanja Schirmeister Johannes Gutenberg University of Mainz
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
J. Andrew McCammon
J. Andrew McCammon University of California, San Diego

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