World's Best Scientists 2026 revealed!
Christoph A. Sotriffer

Christoph A. Sotriffer

D-Index & Metrics

Chemistry

D-Index
41
Citations
6070
World Ranking
17775
National Ranking
1287

Overview

Christoph A. Sotriffer is affiliated with the University of Würzburg in Germany. Their research spans multiple disciplines within the life sciences, primarily focusing on biochemistry, genetics, and molecular biology, supported by 49 publications in these areas. Medicine is another key field of study, with 28 related publications. The scientist's work extends into several subfields, including molecular biology, materials chemistry, pharmacology, organic chemistry, and cellular and molecular neuroscience.

The main topics addressed in their research include protein structure and dynamics, ubiquitin and proteasome pathways, and computational drug discovery methods. Other notable topics cover protein degradation and inhibitors, multiple myeloma research and treatments, photochromic and fluorescence chemistry, and neuroscience and neuropharmacology research.

Several frequently published venues underline the dissemination of their research findings. These include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ChemMedChem
  • ACS Chemical Neuroscience
  • Molecular Pharmaceutics

Christoph A. Sotriffer has collaborated regularly with several co-authors, including:

  • Josef Kehrein (11 joint publications)
  • Michael Decker (9 joint publications)
  • Mathias Diebold (7 joint publications)
  • Ute A. Hellmich (7 joint publications)
  • Bikash Adhikari (6 joint publications)

Representative recent papers illustrate the diversity and focus of this work. Examples include:

  • "PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase" published in 2020 in Nature Chemical Biology
  • "Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders" published in 2021 in Journal of Medicinal Chemistry
  • "Melatonin receptor ligands: A pharmaco-chemical perspective" published in 2020 in Journal of Pineal Research
  • "Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model" published in 2021 in Journal of Medicinal Chemistry
  • "Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2" published in 2020 in ChemMedChem

Best Publications

  • Discovery of a novel binding trench in HIV integrase.

    Julie R. Schames;Richard H. Henchman;Jay S. Siegel;Christoph A. Sotriffer

  • Target flexibility: an emerging consideration in drug discovery and design.

    Pietro Cozzini;Glen E. Kellogg;Francesca Spyrakis;Donald J. Abraham

  • Structure-Based Search for New Inhibitors of Cholinesterases

    Marek Bajda;Anna Więckowska;Michalina Hebda;Natalia Guzior

  • SFCscore(RF): a random forest-based scoring function for improved affinity prediction of protein-ligand complexes.

    David Zilian;Christoph A. Sotriffer

  • Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase.

    David C Rowley;Mark S.T Hansen;Denise Rhodes;Christoph A Sotriffer

  • PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

    Bikash Adhikari;Jelena Bozilovic;Jelena Bozilovic;Mathias Diebold;Jessica Denise Schwarz

  • Identification and mapping of small-molecule binding sites in proteins: computational tools for structure-based drug design

    Christoph Sotriffer;Gerhard Klebe

  • Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions.

    Holger Steuber;Matthias Zentgraf;Christof Gerlach;Christoph A. Sotriffer

  • SFCscore: scoring functions for affinity prediction of protein-ligand complexes.

    Christoph A. Sotriffer;Paul Sanschagrin;Hans Matter;Gerhard Klebe

  • Docking into knowledge-based potential fields: a comparative evaluation of DrugScore.

    Christoph A. Sotriffer;Holger Gohlke;Gerhard Klebe

  • Active site binding modes of HIV-1 integrase inhibitors.

    Christoph A. Sotriffer;and Haihong Ni;J. Andrew McCammon

  • AffinDB: a freely accessible database of affinities for protein–ligand complexes from the PDB

    Peter Block;Christoph A. Sotriffer;Ingo Dramburg;Gerhard Klebe

  • Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.

    Edgar Sawatzky;Sarah Wehle;Beata Kling;Jan Wendrich

  • Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.

    Christoph A. Sotriffer;Oliver Krämer;Gerhard Klebe

  • Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation.

    Xinyu Chen;Sarah Wehle;Natascha Kuzmanovic;Benjamin Merget

  • Automated docking of ligands to antibodies: methods and applications.

    Christoph A. Sotriffer;Wolfgang Flader;Rudolf H. Winger;Bernd M. Rode

  • Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.

    Fouad H. Darras;Steffen Pockes;Guozheng Huang;Sarah Wehle

  • Ordered water and ligand mobility in the HIV-1 integrase-5CITEP complex: a molecular dynamics study.

    Haihong Ni;and Christoph A. Sotriffer;J. Andrew McCammon

  • Protonation Changes upon Ligand Binding to Trypsin and Thrombin: Structural Interpretation Based on pKa Calculations and ITC Experiments

    Paul Czodrowski;Christoph A. Sotriffer;Gerhard Klebe

  • Accounting for Induced-Fit Effects in Docking: What is Possible and What is Not?

    Christoph A. Sotriffer

  • Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.

    Matthias Hoffmann;Carina Stiller;Erik Endres;Matthias Scheiner

  • Physicochemical descriptors to discriminate protein-protein interactions in permanent and transient complexes selected by means of machine learning algorithms.

    Peter Block;Juri Paern;Eyke Hüllermeier;Paul Sanschagrin

Frequent Co-Authors

Gerhard Klebe
Gerhard Klebe Philipp University of Marburg
Ulrike Holzgrabe
Ulrike Holzgrabe University of Würzburg
Caroline Kisker
Caroline Kisker University of Würzburg
Bernd M. Rode
Bernd M. Rode University of Innsbruck
Peter J. Tonge
Peter J. Tonge Stony Brook University
Klaus R. Liedl
Klaus R. Liedl University of Innsbruck
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Tanja Schirmeister
Tanja Schirmeister Johannes Gutenberg University of Mainz
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
J. Andrew McCammon
J. Andrew McCammon University of California, San Diego

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, exploring related fields such as forensic science and criminal justice can open exciting career opportunities. Many universities now offer specialized programs like a forensic science bachelor degree online, blending chemical principles with criminal investigation techniques. This interdisciplinary approach helps graduates apply their chemistry knowledge in practical, impactful ways.

Advancing further, a master’s in forensic psychology online allows students to deepen their understanding of human behavior and legal processes. Such programs often complement chemistry expertise with psychological insights, especially in forensic labs and research settings.

When considering career prospects, it’s important to evaluate potential earnings. According to recent data, a forensic science degree salary can be competitive, reflecting the demand for skilled professionals in crime labs, law enforcement, and government agencies.

Finally, prospective students should weigh the financial investment. Understanding criminal justice degree cost insights helps plan educational expenses effectively. Many online programs offer affordable options to balance quality education with budget constraints.

Best Scientists Citing Christoph A. Sotriffer

Trending Scientists

Recently Published Articles