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Jukka-Pekka Mecklin

Jukka-Pekka Mecklin

D-Index & Metrics

Medicine

D-Index
101
Citations
52057
World Ranking
7822
National Ranking
86

Overview

Jukka-Pekka Mecklin is affiliated with the University of Jyväskylä in Finland. Their research primarily focuses on genetic factors in colorectal cancer, contributing substantially across several related fields of study including Medicine and Biochemistry, Genetics and Molecular Biology.

Their expertise spans multiple subfields such as Pathology and Forensic Medicine, Oncology, Cancer Research, Molecular Biology, and Surgery. The scientist's work also extensively covers important topics like Genetic factors in colorectal cancer, Cancer Genomics and Diagnostics, Cancer Immunotherapy and Biomarkers, Colorectal Cancer Screening and Detection, Colorectal Cancer Treatments and Studies, Cancer-related molecular mechanisms research, and Colorectal and Anal Carcinomas.

Jukka-Pekka Mecklin has published numerous papers in notable venues, with frequent publications appearing in Gastroenterology, British Journal of Cancer, International Journal of Cancer, Cancers, and bioRxiv (Cold Spring Harbor Laboratory).

Their recent significant papers include:

  • Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial (2020, The Lancet)
  • Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer (2021, Gastroenterology)
  • Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study (2020, BJS Open)
  • The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution (2020, Nature Communications)
  • Lynch Syndrome Genetics and Clinical Implications (2023, Gastroenterology)

They regularly collaborate with other researchers, with frequent co-authors including Toni T. Seppälä, Maarit Ahtiainen, Jan Böhm, Erkki-Ville Wirta, and Anna Lepistö.

Best Publications

  • Clues to the pathogenesis of familial colorectal cancer

    Lauri A. Aaltonen;Päivi Peltomäki;Fredrick S. Leach;Pertti Sistonen

  • New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

    Hans F.A. Vasen;Patrice Watson;Jukka–Pekka Mecklin;Henry T. Lynch

  • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

    Fredrick S. Leach;Nicholas C. Nicolaides;Nickolas Papadopoulos;Bo Liu

  • Mutation of a mutL homolog in hereditary colon cancer

    Nickolas Papadopoulos;Nicholas C. Nicolaides;Ying Fei Wei;Steven M. Ruben

  • Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

    Heikki J. Järvinen;Markku Aarnio;Harri Mustonen;Katja Aktan–Collan‡

  • Cancer risk in mutation carriers of DNA-mismatch-repair genes.

    M. Aarnio;R. Sankila;E. Pukkala;R. Salovaara

  • Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

    L A Aaltonen;R Salovaara;P Kristo;F Canzian

  • Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer

    Päivi Peltomäki;Lauri A. Aaltonen;Pertti Sistonen;Lea Pylkkänen

  • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

    John Burn;Anne Marie Gerdes;Finlay MacRae;Jukka Pekka Mecklin

  • Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

    Hans F A Vasen;Ignacio Blanco;Katja Aktan-Collan;Jessica P Gopie

  • Replication Errors in Benign and Malignant Tumors from Hereditary Nonpolyposis Colorectal Cancer Patients

    Lauri A. Aaltonen;Päivi Peltomäki;Jukka Pekka Mecklin;Heikki Järvinen

  • Life‐time risk of different cancers in hereditary non‐polyposis colorectal cancer (hnpcc) syndrome

    Markku Aarnio;Jukka-Pekka Mecklin;Lauri A. Aaltonen;Minna Nyström-Lahti

  • Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer

    Reijo Salovaara;Anu Loukola;Paula Kristo;Helena Kääriäinen

  • Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

    Hans F.A. Vasen;Gabriele Möslein;Angel Alonso;Inge Bernstein

  • Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer

    Heikki J. Järvinen;Jukka-Pekka Mecklin;Pertti Sistonen

  • The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome

    Patrice Watson;Hans F.A. Vasen;Jukka Pekka Mecklin;Inge Bernstein

  • The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

    Sari Tuupanen;Mikko Turunen;Rainer Lehtonen;Outi Hallikas

  • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

    Pål Møller;Toni T Seppälä;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

    Pal Moller;Toni Seppala;Inge Bernstein;Inge Bernstein;Elke Holinski-Feder

  • Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer

    John Burn;Anne-Marie Gerdes;Finlay Macrae;Jukka-Pekka Mecklin

Frequent Co-Authors

Heikki Järvinen
Heikki Järvinen University of Helsinki
Lauri A. Aaltonen
Lauri A. Aaltonen University of Helsinki
Päivi Peltomäki
Päivi Peltomäki University of Helsinki
Hans F. A. Vasen
Hans F. A. Vasen Leiden University
Ari Ristimäki
Ari Ristimäki University of Helsinki
Jussi Taipale
Jussi Taipale University of Cambridge
John Burn
John Burn Newcastle University
Richard S. Houlston
Richard S. Houlston Institute of Cancer Research
Ian Tomlinson
Ian Tomlinson University of Oxford
D. Gareth Evans
D. Gareth Evans University of Manchester

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