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Biology and Biochemistry

D-Index
53
Citations
7384
World Ranking
16386
National Ranking
1175

Overview

Hiroshi Ide is affiliated with Hiroshima University in Japan and is active in research primarily within the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans several interconnected subfields including Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Pharmacology, and Molecular Medicine.

The main topics addressed in their research focus substantially on DNA repair mechanisms and cancer-related processes. Additional areas of study include PARP inhibition in cancer therapy, antibiotics pharmacokinetics and efficacy, antibiotic resistance in bacteria, carcinogens and genotoxicity assessment, and ion-surface interactions and analysis.

Hiroshi Ide has published extensively, with notable papers including the following:

  • Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy, 2022, Proceedings of the National Academy of Sciences
  • Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1), 2020, DNA Repair
  • Risk factors for placenta accreta spectrum in pregnancies conceived after frozen-thawed embryo transfer in a hormone replacement cycle, 2024, European Journal of Obstetrics & Gynecology and Reproductive Biology
  • Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding, 2023, Journal of Biological Chemistry
  • Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells, 2020, PLoS ONE

Ide publishes frequently in venues such as the Journal of Radiation Research, Scientific Reports, Proceedings of the National Academy of Sciences, DNA Repair, and the European Journal of Obstetrics & Gynecology and Reproductive Biology.

Collaborative work with coauthors is a significant component of Ide's research output. Frequent collaborators include Masataka Tsuda, Toshiaki Nakano, Mahmoud I. Shoulkamy, Ryosuke Morozumi, and Ken Akamatsu.

Best Publications

  • Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro

    Hiroshi Ide;Yoke Wah Kow;Susan S. Wallace

  • The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

    Laurent Gros;Alexander A. Ishchenko;Hiroshi Ide;Rhoderick H. Elder

  • A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion.

    Kihei Kubo;Hiroshi Ide;Susan S. Wallace;Yoke W. Kow

  • Isolation and characterization of endonuclease VIII from Escherichia coli

    Robert J. Melamede;Zafer Hatahet;Yoke W. Kow;Hiroshi Ide

  • Synthesis and damage specificity of a novel probe for the detection of abasic sites in DNA

    Hiroshi Ide;Ken Akamatsu;Yoshiharu Kimura;Kenji Michiue

  • Protective Roles of Bacterioruberin and Intracellular KCl in the Resistance of Halobacterium salinarium against DNA-damaging Agents

    Hamid Reza Shahmohammadi;Ezat Asgarani;Hiroaki Terato;Takeshi Saito

  • Human DNA Glycosylases Involved in the Repair of Oxidatively Damaged DNA

    Hiroshi Ide;Mitsuharu Kotera

  • Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

    Masashi Takao;Shin Ichiro Kanno;Tatsuya Shiromoto;Rei Hasegawa

  • Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine.

    Kenjiro Asagoshi;Takao Yamada;Hiroaki Terato;Yoshihiko Ohyama

  • Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.

    Aya Masaoka;Mayumi Matsubara;Rei Hasegawa;Tamon Tanaka

  • Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells

    Toshiaki Nakano;Atsushi Katafuchi;Mayumi Matsubara;Hiroaki Terato

  • Isolation and Characterization of a Novel Product, 2‘-Deoxyoxanosine, from 2‘-Deoxyguanosine, Oligodeoxynucleotide, and Calf Thymus DNA Treated by Nitrous Acid and Nitric Oxide

    Toshinori Suzuki;Ryohei Yamaoka;Masatoshi Nishi;Hiroshi Ide

  • Differential Specificity of Human and Escherichia coli Endonuclease III and VIII Homologues for Oxidative Base Lesions

    Atsushi Katafuchi;Toshiaki Nakano;Aya Masaoka;Hiroaki Terato

  • .alpha.-Deoxyadenosine, a Major Anoxic Radiolysis Product of Adenine in DNA, Is a Substrate for Escherichia coli Endonuclease IV

    Hiroshi Ide;Kei Tedzuka;Hironori Shimzu;Yoshiharu Kimura

  • Repair and biochemical effects of DNA-protein crosslinks.

    Hiroshi Ide;Mahmoud I. Shoulkamy;Toshiaki Nakano;Mayumi Miyamoto-Matsubara

  • Microvoid formation process during the plastic deformation of β-form polypropylene

    Feng Chu;Tetsuji Yamaoka;Hiroshi Ide;Yoshiharu Kimura

  • DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage.

    Toshiaki Nakano;Hiroaki Terato;Kenjiro Asagoshi;Aya Masaoka

  • Processing of DNA base damage by DNA polymerases. Dihydrothymine and beta-ureidoisobutyric acid as models for instructive and noninstructive lesions.

    H Ide;L A Petrullo;Z Hatahet;S S Wallace

  • Quantitative Analysis of Isolated and Clustered DNA Damage Induced by Gamma-rays, Carbon Ion Beams, and Iron Ion Beams

    Hiroaki Terato;Ruri Tanaka;Yusuke Nakaarai;Tomonori Nohara

  • Substrate and Mispairing Properties of 5-Formyl-2′-Deoxyuridine 5′-Triphosphate Assessed by in vitro DNA Polymerase Reactions

    Mitsuo Yoshida;Keisuke Makino;Hajime Morita;Hiroaki Terato

Frequent Co-Authors

Keisuke Makino
Keisuke Makino Kyoto University
Yoshiharu Kimura
Yoshiharu Kimura Kyoto Institute of Technology
Susan S. Wallace
Susan S. Wallace University of Vermont
Sei-ichi Nishimoto
Sei-ichi Nishimoto Kyoto University
Bernard F. Erlanger
Bernard F. Erlanger Columbia University
Shigenori Iwai
Shigenori Iwai Osaka University
Minoru Takata
Minoru Takata Kyoto University
Ichizo Kobayashi
Ichizo Kobayashi University of Tokyo
Akira Yasui
Akira Yasui Tohoku University
Fumio Hanaoka
Fumio Hanaoka National Institute of Genetics

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