World's Best Scientists 2026 revealed!

Overview

Harold G. Selnick is affiliated with MSD in the United States and conducts research primarily in the areas of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several specialized subfields, including Molecular Biology, Organic Chemistry, Physiology, Cellular and Molecular Neuroscience, and Psychiatry and Mental Health.

Their recent research contributions include studies on glycosylation processes and carbohydrate chemistry, with a notable focus on lysosomal storage disorders, neuropeptides, and migraines. This thematic focus underpins their exploration of animal physiology and protein biology, such as S100 proteins and annexins.

Harold G. Selnick has published in reputable scientific journals, with recent papers appearing in:

  • MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy (2020), Journal of Pharmacology and Experimental Therapeutics
  • Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists (2024), Bioorganic & Medicinal Chemistry Letters

Frequent collaborators on these research projects include Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, and Lixin Song.

The research topics addressed by Harold G. Selnick encompass:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Lysosomal Storage Disorders Research
  • Neuropeptides and Animal Physiology
  • Migraine and Headache Studies
  • S100 Proteins and Annexins

Their work has contributed to a multi-disciplinary understanding of molecular mechanisms underlying neurological and physiological conditions, linking biochemical pathways with clinical implications in medicine. The combination of recent contributions in both molecular neuroscience and organic chemistry reflects a broad interest in molecular targeting and therapeutic innovation.

Best Publications

  • In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

    James C. Barrow;Philippe G. Nantermet;Harold G. Selnick;Kristen L. Glass

  • 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use

    Stephen E. de Laszlo;Nigel J. Liverton;Gerald S. Ponticello;Harold G. Selnick

  • Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

    Abbas M. Walji;Eric D. Hostetler;Harold Selnick;Zhizhen Zeng

  • In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

    Eric D. Hostetler;Aniket D. Joshi;Sandra Sanabria-Bohórquez;Hong Fan

  • Total synthesis of zincophorin

    Samuel J. Danishefsky;Harold G. Selnick;Robert E. Zelle;Michael P. DeNinno

  • Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

    Nicholas B. Hastings;Xiaohai Wang;Lixin Song;Brent D. Butts

  • Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

    Harold G. Selnick;Nigel J. Liverton;John J. Baldwin;John W. Butcher

  • Substituted imidazoles having anti-cancer and cytokine inhibitory activity

    Harold G. Selnick;David A. Claremon;Nigel J. Liverton

  • First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

    Sethu Sankaranarayanan;Marie A. Holahan;Dennis Colussi;Ming-Chih Crouthamel

  • Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.

    Harold G Selnick;J Fred Hess;Cuyue Tang;Kun Liu

  • Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).

    Hemaka A. Rajapakse;Philippe G. Nantermet;Harold G. Selnick;Sanjeev Munshi

  • Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

    Christopher A. Salvatore;Eric L. Moore;Amy Calamari;Jacquelynn J. Cook

  • Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors

    Mary Beth Young;James C. Barrow;Kristen L. Glass;George F. Lundell

  • A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

    James C Barrow;Phung L Ngo;Janetta M Pellicore;Harold G Selnick

  • Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

    Nathaniel L Elsen;Sangita B Patel;Rachael E Ford;Dawn L Hall

  • Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group.

    Philippe G. Nantermet;James C. Barrow;Stacey R. Lindsley;Marybeth Young

  • Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid

    Matthew G. Stanton;Shaun R. Stauffer;Alison R. Gregro;Melissa Steinbeiser

  • Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

    James C. Barrow;Shaun R. Stauffer;Kenneth E. Rittle;Phung L. Ngo

  • Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

    Shaun R. Stauffer;Matthew G. Stanton;Alison R. Gregro;Melissa A. Steinbeiser

  • The total synthesis of zincophorin

    Samuel J. Danishefsky;Harold G. Selnick;Michael P. DeNinno;Robert E. Zelle

Frequent Co-Authors

Joseph P. Vacca
Joseph P. Vacca MSD (United States)
David J. Vocadlo
David J. Vocadlo Simon Fraser University
Shaun R. Stauffer
Shaun R. Stauffer Cleveland Clinic
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Richard Hargreaves
Richard Hargreaves Harvard Medical School
Jules A. Shafer
Jules A. Shafer MSD (United States)

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