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D-Index & Metrics

Chemistry

D-Index
54
Citations
9082
World Ranking
12760
National Ranking
3378

Overview

Jules A. Shafer is affiliated with MSD (United States) and based in the United States. Their academic profile is characterized by recent research activities, although specific recent papers, publication venues, and citation metrics have not been listed.

The scientist does not currently have recorded frequent co-authors or documented collaborations that are publicly available in the provided data. Similarly, no frequent publication venues or book publications have been detailed.

Information about Jules A. Shafer's main fields of study, subfields of study, and main topics of work is not provided in the available dataset. There are no recorded awards or distinctions associated with the scientist at this time.

Jules A. Shafer's work and career status indicate they are active, as there is no indication of being deceased. The data reflects a focus on MSD affiliation within the United States, which may indicate involvement in industry-related or applied research contexts.

Best Publications

  • Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

    Y M Li;M Xu;M T Lai;Q Huang

  • Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.

    Yue-Ming Li;Ming-Tain Lai;Min Xu;Qian Huang

  • Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate.

    David D. Roberts;Sidney D. Lewis;David P. Ballou;Steven T. Olson

  • Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.

    Zhongguo Chen;Ying Li;E. Chen;D. L. Hall

  • Effect of cysteine-25 on the ionization of histidine-159 in papain as determined by proton nuclear magnetic resonance spectroscopy. Evidence for a his-159--Cys-25 ion pair and its possible role in catalysis.

    Sidney D. Lewis;Frederick Allen Johnson;Jules A. Shafer

  • Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin.

    D L Higgins;S D Lewis;J A Shafer

  • The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.

    M.C. Naski;J.W. Fenton nd;J.M. Maraganore;S.T. Olson

  • The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain *

    Xiao-Ping Shi;Elizabeth Chen;Kuo-Chang Yin;Sang Na

  • Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans.

    Shi-Shan Mao;Carolyn M. Cooper;Theresa Wood;Jules A. Shafer

  • Potentiometric determination of ionizations at the active site of papain.

    Sidney D. Lewis;Frederick A. Johnson;Jules A. Shafer

  • Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

    Dennis T. Pang;Baldev R. Sharma;Jules A. Shafer

  • Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytes

    Carol M. Foster;Jules A. Shafer;Frank W. Rozsa;Xueyan Wang

  • An Antibody Against the Exosite of the Cloned Thrombin Receptor Inhibits Experimental Arterial Thrombosis in the African Green Monkey

    Jacquelynn J. Cook;Gary R. Sitko;Bohumil Bednar;Cindra Condra

  • Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III.

    Zhong-Ru Gan;Yiping Li;Zhongguo Chen;S. D. Lewis

  • Promotion of thrombin-catalyzed activation of factor XIII by fibrinogen

    Todd J. Janus;Sidney D. Lewis;Laszlo Lorand;Jules A. Shafer

  • Regulation of formation of factor XIIIa by its fibrin substrates.

    Sidney D. Lewis;Todd J. Janus;Laszlo Lorand;Jules A. Shafer

  • Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

    Christopher S. Burgey;Kyle A. Robinson;Terry A. Lyle;Philip E. J. Sanderson

  • Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

    David L. Pompliano;Michael D. Schaber;Scott D. Mosser;Charles A. Omer

  • Phosphorylation of highly purified growth hormone receptors by a growth hormone receptor-associated tyrosine kinase.

    C. Carter-Su;J. R. Stubbart;Xueyan Wang;S. E. Stred

  • Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.

    Philip E. J. Sanderson;Terry A. Lyle;Kellie J. Cutrona;Dona L. Dyer

Frequent Co-Authors

Irwin J. Goldstein
Irwin J. Goldstein University of Michigan–Ann Arbor
Joseph P. Vacca
Joseph P. Vacca MSD (United States)
Christin Carter-Su
Christin Carter-Su University of Michigan–Ann Arbor
Laszlo Lorand
Laszlo Lorand Northwestern University
James E. Bruce
James E. Bruce University of Washington
David B. Olsen
David B. Olsen MSD (United States)
George D. Hartman
George D. Hartman Janssen (Belgium)
David D. Roberts
David D. Roberts National Institutes of Health
Jackson B. Gibbs
Jackson B. Gibbs George Washington University
Harold G. Selnick
Harold G. Selnick MSD (United States)

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