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Molecular Biology

D-Index
53
Citations
10628
World Ranking
2386
National Ranking
56

Overview

Haico van Attikum is affiliated with Leiden University Medical Center in the Netherlands, focusing on biochemistry, genetics, and molecular biology. Their research covers multiple subfields, including molecular biology, oncology, genetics, cancer research, and immunology. The principal thematic areas of their work involve DNA repair mechanisms, CRISPR and genetic engineering, PARP inhibition in cancer therapy, genomics and chromatin dynamics, ubiquitin and proteasome pathways, BRCA gene mutations in cancer, and RNA modifications related to cancer.

Van Attikum has contributed extensively to the scientific literature, with a substantial number of publications primarily centered on the mechanisms that maintain genome integrity and influence cancer biology. Recent notable papers include:

  • HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage (2023, Nature Structural & Molecular Biology)
  • Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks (2022, Nature Communications)
  • Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk (2021, Cancer Research)
  • CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks (2020, Nature Communications)
  • Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome (2020, The Journal of Experimental Medicine)

Their frequent collaborators include Magdalena B. Rother, Wouter W. Wiegant, Bert van de Kooij, Sylvie M. Noordermeer, and Alfred C.O. Vertegaal, reflecting a consistent collaboration network within the DNA repair and molecular biology research community.

Van Attikum's work has been published predominantly in venues specializing in molecular biology and cancer research. The most frequent publication outlets are bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Zenodo (CERN European Organization for Nuclear Research), Cancer Research, and The Journal of Experimental Medicine.

Overall, the research contributions of Haico van Attikum address fundamental processes of DNA damage response and repair, with applications relevant to cancer genetics and therapeutic approaches. The investigation of CRISPR-mediated DNA double-strand break repair and the role of protein factors in chromatin dynamics are central themes in their published scholarship.

Best Publications

  • Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair

    Haico van Attikum;Olivier Fritsch;Barbara Hohn;Susan M. Gasser

  • Crosstalk between histone modifications during the DNA damage response.

    Haico van Attikum;Susan M. Gasser

  • The Shieldin complex mediates 53BP1-dependent DNA repair

    Sylvie M. Noordermeer;Sylvie M. Noordermeer;Salomé Adam;Dheva Setiaputra;Marco Barazas

  • Rewiring of genetic networks in response to DNA damage

    Sourav Bandyopadhyay;Monika Mehta;Dwight Kuo;Min Kyung Sung

  • Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks

    Haico van Attikum;Olivier Fritsch;Susan M Gasser

  • The histone code at DNA breaks: a guide to repair?

    Haico van Attikum;Susan M. Gasser

  • PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells.

    Sylvie M. Noordermeer;Haico van Attikum

  • Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

    Ewa Gogola;Alexandra A. Duarte;Julian R. de Ruiter;Wouter W. Wiegant

  • The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

    Thomas Costelloe;Raphaël Louge;Raphaël Louge;Nozomi Tomimatsu;Bipasha Mukherjee

  • The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

    Godelieve Smeenk;Wouter W. Wiegant;Hans Vrolijk;Aldo P. Solari

  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

    Martijn S. Luijsterburg;Inge de Krijger;Wouter W. Wiegant;Rashmi G. Shah

  • Spatiotemporal regulation of posttranslational modifications in the DNA damage response.

    Nico P Dantuma;Haico van Attikum

  • Non‐homologous end‐joining proteins are required for Agrobacterium T‐DNA integration

    Haico van Attikum;Paul Bundock;Paul J. J. Hooykaas

  • The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity

    Godelieve Smeenk;Haico van Attikum

  • DDB2 promotes chromatin decondensation at UV-induced DNA damage

    Martijn S. Luijsterburg;Martijn S. Luijsterburg;Michael Lindh;Klara Acs;Mischa G. Vrouwe

  • A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy

    Rohith Srivas;John Paul Shen;Chih Cheng Yang;Su Ming Sun

  • Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.

    Godelieve Smeenk;Wouter W. Wiegant;Jurgen A. Marteijn;Martijn S. Luijsterburg

  • Chromatin and the DNA damage response: The cancer connection

    Martijn S. Luijsterburg;Haico van Attikum

  • Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

    Paul Bundock;Haico van Attikum;Paul Hooykaas

  • The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T‐DNA

    Haico van Attikum;Paul Bundock;René M. Overmeer;Lan‐Ying Lee

Frequent Co-Authors

Susan M. Gasser
Susan M. Gasser Friedrich Miescher Institute
Trey Ideker
Trey Ideker University of California, San Diego
Paul J. J. Hooykaas
Paul J. J. Hooykaas Leiden University
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Alfred C. O. Vertegaal
Alfred C. O. Vertegaal Leiden University Medical Center
Robert W. Sobol
Robert W. Sobol University of South Alabama
Nico P. Dantuma
Nico P. Dantuma Karolinska Institute
Sven Rottenberg
Sven Rottenberg University of Bern
Jos Jonkers
Jos Jonkers Antoni van Leeuwenhoek Hospital
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam

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