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Nico P. Dantuma

Nico P. Dantuma

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
20328
World Ranking
18813
National Ranking
296

Overview

Nico P. Dantuma is affiliated with the Karolinska Institute in Sweden and specializes in the field of Biochemistry, Genetics and Molecular Biology, focusing predominantly on Molecular Biology. Their research encompasses several subfields including Epidemiology, Cell Biology, Cellular and Molecular Neuroscience, and Oncology.

Their body of work primarily addresses key topics such as ubiquitin and proteasome pathways, autophagy in disease and therapy, endoplasmic reticulum stress and disease, mitochondrial function and pathology, genetic neurodegenerative diseases, PARP inhibition in cancer therapy, and silk-based biomaterials and applications.

Recent notable publications by Nico P. Dantuma include:

  • K63-linked ubiquitylation induces global sequestration of mitochondria, 2020, Scientific Reports
  • Reporter-Based Screens for the Ubiquitin/Proteasome System, 2020, Frontiers in Chemistry
  • MacroGreen, a simple tool for detection of ADP-ribosylated proteins, 2021, Communications Biology
  • Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment, 2022, The EMBO Journal
  • Functionalization of amyloid fibrils via the Bri2 BRICHOS domain, 2020, Scientific Reports

Their research has appeared frequently in publication venues such as Communications Biology, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Autophagy, and Frontiers in Chemistry.

Collaborations are a significant aspect of Nico P. Dantuma's work. Frequent co-authors include Florian A. Salomons, Maria E. Gierisch, Laura K. Herzog, Shanshan Xu, and Tatiana A. Giovannucci.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

    Nico P. Dantuma;Kristina Lindsten;Rickard Glas;Marianne Jellne

  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.

    Emilie Tresse;Florian A. Salomons;Jouni Vesa;Laura C. Bott

  • Aggregate formation inhibits proteasomal degradation of polyglutamine proteins

    Lisette G.G.C. Verhoef;Kristina Lindsten;Maria G. Masucci;Nico P. Dantuma

  • A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

    Nico P. Dantuma;Tom A.M. Groothuis;Florian A. Salomons;Jacques Neefjes

  • The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.

    Nico P. Dantuma;Laura C. Bott

  • DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

    Steven Bergink;Florian A. Salomons;Deborah Hoogstraten;Tom A.M. Groothuis

  • Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome

    Mark Kristiansen;Pelagia Deriziotis;Derek E. Dimcheff;Graham S. Jackson

  • The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

    Klara Acs;Martijn S Luijsterburg;Martijn S Luijsterburg;Leena Ackermann;Florian A Salomons

  • Heterochromatin protein 1 is recruited to various types of DNA damage

    Martijn S. Luijsterburg;Martijn S. Luijsterburg;Christoffel Dinant;Hannes Lans;Jan Stap

  • Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin–proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

    Aaron B. Bowman;Seung-Yun Yoo;Nico P. Dantuma;Huda Y. Zoghbi

  • Endoplasmic reticulum stress compromises the ubiquitin–proteasome system

    Victoria Menéndez-Benito;Lisette G.G.C. Verhoef;Maria G. Masucci;Nico P. Dantuma

  • A transgenic mouse model of the ubiquitin/proteasome system.

    Kristina Lindsten;Victoria Menéndez-Benito;Maria G Masucci;Nico P Dantuma

  • Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

    Kristina Lindsten;Femke M.S. de Vrij;Lisette G.G.C. Verhoef;David F. Fischer

  • Spatiotemporal regulation of posttranslational modifications in the DNA damage response.

    Nico P Dantuma;Haico van Attikum

  • A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

    Martijn Verdoes;Bogdan I. Florea;Victoria Menendez-Benito;Christa J. Maynard

  • Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis†

    Cristina Cheroni;Marianna Marino;Massimo Tortarolo;Pietro Veglianese

  • Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

    Jurgen A. Marteijn;Simon Bekker-Jensen;Niels Mailand;Hannes Lans

  • The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.

    Nico P. Dantuma;Christian Heinen;Deborah Hoogstraten

  • DDB2 promotes chromatin decondensation at UV-induced DNA damage

    Martijn S. Luijsterburg;Martijn S. Luijsterburg;Michael Lindh;Klara Acs;Mischa G. Vrouwe

Frequent Co-Authors

Maria G. Masucci
Maria G. Masucci Karolinska Institute
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
J. Paul Taylor
J. Paul Taylor St. Jude Children's Research Hospital
Haico van Attikum
Haico van Attikum Leiden University Medical Center
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Hilkka Soininen
Hilkka Soininen University of Eastern Finland
Lars Bertram
Lars Bertram University of Lübeck
Jan Konvalinka
Jan Konvalinka Czech Academy of Sciences
Kenneth H. Fischbeck
Kenneth H. Fischbeck National Institutes of Health
Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University

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