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Neuroscience

D-Index
46
Citations
29759
World Ranking
6555
National Ranking
2844

Overview

Scott Zeitlin is affiliated with the University of Virginia in the United States and conducts research primarily in the fields of biochemistry, genetics, molecular biology, and neuroscience. Their work explores molecular and cellular mechanisms underlying neurological conditions, with a focus on genetic neurodegenerative diseases and mitochondrial function and pathology.

The scientist's research spans several subfields, including molecular biology, cellular and molecular neuroscience, and aspects of cell biology and neurology. The main topics they cover in their publications include:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Muscle Physiology and Disorders
  • Neurological disorders and treatments
  • Microtubule and mitosis dynamics
  • Endoplasmic Reticulum Stress and Disease
  • RNA Research and Splicing

Scott Zeitlin has published extensively on Huntington's disease and related neurodevelopmental and neurodegenerative processes. Recent papers include:

  • "Huntington's disease alters human neurodevelopment," 2020, Science
  • "Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival," 2020, Cell Reports
  • "Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease," 2022, Cell Systems
  • "Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model," 2022, JCI Insight
  • "Huntingtin lowering reduces somatic instability at CAG-expanded loci," 2020, bioRxiv (Cold Spring Harbor Laboratory)

The most frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Science, Cell Reports, Cell Systems, and JCI Insight.

Scott Zeitlin collaborates regularly with several coauthors, notable among them are:

  • Jeh-Ping Liu
  • David Howland
  • Jeffrey P. Cantle
  • Jeffrey B. Carroll
  • Deanna M. Marchionini

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue.

    Scott Zeitlin;Jeh-Ping Liu;Deborah L. Chapman;Virginia E. Papaioannou

  • Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.

    Ioannis Dragatsis;Michael S. Levine;Scott Zeitlin;Scott Zeitlin

  • Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

    Liliana B. Menalled;Jessica D. Sison;Ioannis Dragatsis;Scott Zeitlin

  • Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

    Eugenia Trushina;Roy B. Dyer;John D. Badger;Daren Ure

  • IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

    Leslie Michels Thompson;Charity T. Aiken;Linda S. Kaltenbach;Namita Agrawal

  • Enhanced sensitivity to N‐methyl‐D‐aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

    Michael S. Levine;Gloria J. Klapstein;Ahrin Koppel;Ehud Gruen

  • Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses.

    Stanislav S Zakharenko;Stanislav S Zakharenko;Susan L Patterson;Ioannis Dragatsis;Scott O Zeitlin

  • RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

    M B Soares;E Schon;A Henderson;S K Karathanasis

  • Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1α Reduces Rather Than Increases Hypoxic-Ischemic Damage

    Rob Helton;Jiankun Cui;John R. Scheel;Julie A. Ellison

  • Huntington’s disease alters human neurodevelopment

    Monia Barnat;Mariacristina Capizzi;Esther Aparicio;Susana Boluda

  • Widespread Disruption of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy at Its Target Genes in Huntington's Disease

    Chiara Zuccato;Nikolai D Belyaev;Paola Conforti;Lezanne Ooi

  • Potential function for the Huntingtin protein as a scaffold for selective autophagy.

    Joseph Ochaba;Tamás Lukacsovich;George Csikos;Shuqiu Zheng

  • In vivo splicing products of the rabbit β-globin pre-mRNA

    Scott Zeitlin;Argiris Efstratiadis

  • Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice

    Liliana B. Menalled;Jessica D. Sison;Ying Wu;Melisa Olivieri

  • Pre-mRNA splicing and the nuclear matrix.

    S Zeitlin;A Parent;S Silverstein;A Efstratiadis

  • Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice.

    Miriam A. Hickey;Agata Kosmalska;Joseph Enayati;Rachel Cohen

  • Null Mutation of the Murine ATP7B (Wilson Disease) Gene Results in Intracellular Copper Accumulation and Late-Onset Hepatic Nodular Transformation

    O. I. Buiakova;Jin Xu;S. Lutsenko;S. Zeitlin

  • Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family.

    Marcelo Bento Soares;Arthur Turken;Douglas Ishii;Leslie Mills

Frequent Co-Authors

Argiris Efstratiadis
Argiris Efstratiadis Biomedical Research Foundation of the Academy of Athens
Marie-Françoise Chesselet
Marie-Françoise Chesselet University of California, Los Angeles
Henry H. Yin
Henry H. Yin Duke University
Michael S. Levine
Michael S. Levine Princeton University
Marian DiFiglia
Marian DiFiglia Harvard University
Changlian Zhu
Changlian Zhu University of Gothenburg
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
Tibor Vellai
Tibor Vellai Eötvös Loránd University
Mark R. Cookson
Mark R. Cookson National Institutes of Health
Ken Cadwell
Ken Cadwell New York University

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