Kazuko Handa

Overview

Best Publications

• GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells

  Kazuhisa Iwabuchi;Soichiro Yamamura;Alessandro Prinetti;Kazuko Handa

  418
  Citations

• Separation of 'glycosphingolipid signaling domain' from caveolin- containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling

  Kazuhisa Iwabuchi;Kazuko Handa;Sen Itiroh Hakomori

  401
  Citations

• New insights in glycosphingolipid function: “glycosignaling domain,” a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling

  Sen-itiroh Hakomori;Kazuko Handa;Kazuhisa Iwabuchi;Soichiro Yamamura

  400
  Citations

• Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor

  Seon-Joo Yoon;Ken-ichi Nakayama;Toshiyuki Hikita;Kazuko Handa

  260
  Citations

• Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Lea and sialosyl-Lex, and sulfated glycans modulate this binding

  Kazuko Handa;Edward D. Nudelman;Mark R. Stroud;Tanri Shiozawa

  234
  Citations

• Motility Inhibition and Apoptosis Are Induced by Metastasis-suppressing Gene Product CD82 and Its Analogue CD9, with Concurrent Glycosylation

  Masaya Ono;Kazuko Handa;Donald A. Withers;Sen-itiroh Hakomori

  213
  Citations

• GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.

  Masaya Ono;Kazuko Handa;Sandro Sonnino;Donald A. Withers

  210
  Citations

• Signal Transduction Through Glyco(sphingo)lipids: Introduction and Recent Studies on Glyco(sphingo)lipid-enriched Microdomainsa

  Sen-Itiroh Hakomori;Soichiro Yamamura;Kazuko Handa

  193
  Citations

• Ganglioside GM2-Tetraspanin CD82 Complex Inhibits Met and Its Cross-talk with Integrins, Providing a Basis for Control of Cell Motility through Glycosynapse

  Adriane Regina Todeschini;Jose Nilson Dos Santos;Kazuko Handa;Sen-itiroh Hakomori

  188
  Citations

• Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells.

  Naoya Kojima;Kazuko Handa;Walter Newman;Sen-itiroh Hakomori

  187
  Citations

• Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy.

  Senitiroh Hakomori;Kazuko Handa

  183
  Citations

• Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells

  Yuh-Jin Liang;Yao Ding;Yao Ding;Steven B. Levery;Marlin Lobaton

  166
  Citations

• Monosialogangliosides of human myelogenous leukemia HL60 cells and normal human leukocytes. 2. Characterization of E-selectin binding fractions, and structural requirements for physiological binding to E-selectin.

  Mark R. Stroud;Kazuko Handa;Mary Ellen K. Salyan;Kazunori Ito

  161
  Citations

• Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet mediated pathway

  Adriane Regina Todeschini;Jose Nilson Dos Santos;Kazuko Handa;Sen-itiroh Hakomori

  159
  Citations

• A Specific Microdomain (“Glycosynapse 3”) Controls Phenotypic Conversion and Reversion of Bladder Cancer Cells through GM3-mediated Interaction of α3β1 Integrin with CD9

  Koji Mitsuzuka;Kazuko Handa;Makoto Satoh;Yoichi Arai

  157
  Citations

• A close association of GM3 with c-Src and Rho in GM3-enriched microdomains at the B16 melanoma cell surface membrane: a preliminary note.

  Soichiro Yamamura;Kazuko Handa;Sen-itiroh Hakomori

  153
  Citations

• Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines

  Feng Guan;Kazuko Handa;Sen-itiroh Hakomori

  146
  Citations

• A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis.

  Brunhilde Felding-Habermann;Yasuyuki Igarashi;Bruce A. Fenderson;Linda S. Park

  146
  Citations

• Glycosylation Effect on Membrane Domain (GEM) Involved in Cell Adhesion and Motility: A Preliminary Note on Functional α3, α5-CD82 Glycosylation Complex in ldlD 14 Cells

  Masaya Ono;Kazuko Handa;Donald A. Withers;Sen-itiroh Hakomori;Sen-itiroh Hakomori

  144
  Citations

• GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells; Separation of'glycosphingolipid signaling domain' from caveolin- containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling

  K. Iwabuchi;S. Yamamura;A. Prinetti;K. Handa

  0
  Citations