D-Index & Metrics Best Publications

Kazuko Handa

Pacific Northwest Diabetes Research Institute
United States

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 42 Citations 6,334 87 World Ranking 17255 National Ranking 7080

Overview

What is she best known for?

The fields of study Kazuko Handa is best known for:

Gene
Cell membrane
Signal transduction

Biochemistry is frequently linked to Sulfation in her study. Cell biology and Motility are frequently intertwined in her study. Kazuko Handa undertakes multidisciplinary investigations into Motility and Gene in her work. In her work, she performs multidisciplinary research in Gene and Downregulation and upregulation. Her study brings together the fields of CD44 and Cell. Many of her studies involve connections with topics such as Cell and CD44. With her scientific publications, her incorporates both Cell adhesion and Cell adhesion molecule. In her papers, Kazuko Handa integrates diverse fields, such as Cell adhesion molecule and Cell adhesion. Kazuko Handa integrates many fields, such as Glycosphingolipid and Cell membrane, in her works.

Her most cited work include:

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells (286 citations)
Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling (275 citations)
New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling (265 citations)

What are the main themes of her work throughout her whole career to date

Her Cell biology research is linked to Motility and Kinase. Kinase is closely attributed to Cell biology in her study. Her research links Ganglioside with Biochemistry. In most of her Cell studies, her work intersects topics such as Integrin. Integrin is closely attributed to Cell in her research. Her work blends Molecular biology and Cell culture studies together. Kazuko Handa performs multidisciplinary study in Cell culture and Molecular biology in her work. Gene and Transfection are two areas of study in which she engages in interdisciplinary research. In her study, she carries out multidisciplinary Transfection and Gene research.

Kazuko Handa most often published in these fields:

Biochemistry (90.91%)
Cell biology (67.27%)
Cell (45.45%)

What were the highlights of her more recent work (between 2013-2017)?

Biochemistry (100.00%)
Cell biology (100.00%)
Genetics (100.00%)

In recent works Kazuko Handa was focusing on the following fields of study:

As part of her studies on Biochemistry, Kazuko Handa often connects relevant areas like Glycoconjugate. She combines topics linked to Biochemistry with her work on Glycoconjugate. Her Cell biology study frequently links to related topics such as Growth factor receptor. Growth factor receptor and Receptor are commonly linked in her work. Receptor is closely attributed to Epidermal growth factor receptor in her work. In her work, Kazuko Handa performs multidisciplinary research in Epidermal growth factor receptor and Oncogene. While working in this field, she studies both Oncogene and Cell cycle. In her research, Kazuko Handa undertakes multidisciplinary study on Cell cycle and Kinase. She combines Kinase and Autophosphorylation in her research.

Between 2013 and 2017, her most popular works were:

GM3 and cancer (77 citations)
Changes of glycoconjugate expression profiles during early development (27 citations)
Functional role of glycosphingolipids in contact inhibition of growth in a human mammary epithelial cell line (8 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells

Kazuhisa Iwabuchi;Soichiro Yamamura;Alessandro Prinetti;Kazuko Handa.
Journal of Biological Chemistry (1998)

413 Citations

Separation of 'glycosphingolipid signaling domain' from caveolin- containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling

Kazuhisa Iwabuchi;Kazuko Handa;Sen Itiroh Hakomori.
Journal of Biological Chemistry (1998)

396 Citations

New insights in glycosphingolipid function: “glycosignaling domain,” a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling

Sen-itiroh Hakomori;Kazuko Handa;Kazuhisa Iwabuchi;Soichiro Yamamura.
Glycobiology (1998)

393 Citations

Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor

Seon-Joo Yoon;Ken-ichi Nakayama;Toshiyuki Hikita;Kazuko Handa.
Proceedings of the National Academy of Sciences of the United States of America (2006)

241 Citations

Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Lea and sialosyl-Lex, and sulfated glycans modulate this binding

Kazuko Handa;Edward D. Nudelman;Mark R. Stroud;Tanri Shiozawa.
Biochemical and Biophysical Research Communications (1991)

234 Citations

Motility Inhibition and Apoptosis Are Induced by Metastasis-suppressing Gene Product CD82 and Its Analogue CD9, with Concurrent Glycosylation

Masaya Ono;Kazuko Handa;Donald A. Withers;Sen-itiroh Hakomori.
Cancer Research (1999)

210 Citations

GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.

Masaya Ono;Kazuko Handa;Sandro Sonnino;Donald A. Withers.
Biochemistry (2001)

200 Citations

Signal Transduction Through Glyco(sphingo)lipids: Introduction and Recent Studies on Glyco(sphingo)lipid-enriched Microdomainsa

Sen-Itiroh Hakomori;Soichiro Yamamura;Kazuko Handa.
Annals of the New York Academy of Sciences (1998)

190 Citations

Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells.

Naoya Kojima;Kazuko Handa;Walter Newman;Sen-itiroh Hakomori.
Biochemical and Biophysical Research Communications (1992)

186 Citations

Ganglioside GM2-Tetraspanin CD82 Complex Inhibits Met and Its Cross-talk with Integrins, Providing a Basis for Control of Cell Motility through Glycosynapse

Adriane Regina Todeschini;Jose Nilson Dos Santos;Kazuko Handa;Sen-itiroh Hakomori.
Journal of Biological Chemistry (2007)

184 Citations

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