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Biology and Biochemistry

D-Index
57
Citations
17658
World Ranking
13576
National Ranking
5758

Overview

Andrea Fleig is affiliated with the University of Hawaii at Manoa in the United States. Their work spans primarily the fields of Nursing and Medicine, with notable subfields including Nutrition and Dietetics, Sensory Systems, Cardiology and Cardiovascular Medicine, Molecular Biology, and Plant Science.

Their research focuses on several main topics, notably:

  • Magnesium in Health and Disease
  • Trace Elements in Health
  • Ion Channels and Receptors
  • Cannabis and Cannabinoid Research
  • Neonatal and fetal brain pathology
  • Medicinal Plants and Bioactive Compounds
  • Plant Stress Responses and Tolerance

Andrea Fleig has contributed to diverse research published in various scientific journals. Frequent publication venues include:

  • Cell Calcium
  • Journal of the American College of Cardiology
  • Scientific Reports
  • Function
  • Translational Stroke Research

Recent peer-reviewed papers by Fleig include:

  • "Role of TRPM7 kinase in cancer," 2021, Cell Calcium
  • "TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury," 2020, Translational Stroke Research
  • "TRPM7 contributes to progressive nephropathy," 2020, Scientific Reports
  • "Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions," 2020, Cell Calcium
  • "Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead," 2020, Acta Pharmacologica Sinica

The scientist's research frequently addresses ion channel mechanisms, particularly involving TRPM7, and their roles in various pathological conditions such as cancer, nephropathy, and brain injury.

Frequent coauthors who have collaborated on multiple publications with Andrea Fleig include:

  • F. David Horgen
  • Reinhold Penner
  • Zhong-Ping Feng
  • Hong-Shuo Sun
  • Sayuri Suzuki

This network of collaborators indicates active involvement in multidisciplinary research groups focusing on molecular and cellular physiology related to magnesium and ion channels.

Best Publications

  • CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.

    M Vig;Christine Peinelt;A Beck;D L Koomoa

  • LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

    Monica J. S. Nadler;Meredith C. Hermosura;Kazunori Inabe;Anne-Laure Perraud

  • ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

    Anne Laure Perraud;Andrea Fleig;Christopher A. Dunn;Leigh Ann Bagley

  • Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7.

    Carsten Schmitz;Anne-Laure Perraud;Catherine O Johnson;Kazunori Inabe

  • TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.

    Pierre Launay;Andrea Fleig;Anne Laure Perraud;Andrew M Scharenberg

  • Amplification of CRAC current by STIM1 and CRACM1 (Orai1).

    Christine Peinelt;Monika Vig;Dana L. Koomoa;Andreas Beck

  • TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

    Shinichiro Yamamoto;Shunichi Shimizu;Shigeki Kiyonaka;Nobuaki Takahashi

  • CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

    Monika Vig;Andreas Beck;James M. Billingsley;Annette Lis

  • TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions.

    Mahealani K. Monteilh-Zoller;Meredith C. Hermosura;Monica J.S. Nadler;Andrew M. Scharenberg

  • CRACM1, CRACM2, and CRACM3 Are Store-Operated Ca2+ Channels with Distinct Functional Properties

    Annette Lis;Christine Peinelt;Christine Peinelt;Andreas Beck;Andreas Beck;Suhel Parvez;Suhel Parvez

  • TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.

    D Prawitt;Mahealani K Monteilh-Zoller;Lili R Brixel;Christian Spangenberg

  • Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels.

    Martin Kolisek;Andreas Beck;Andrea Fleig;Reinhold Penner

  • TRPM4 Regulates Calcium Oscillations After T Cell Activation

    Pierre Launay;Henrique Cheng;Subhashini Srivatsan;Reinhold Penner

  • TRPM7 is essential for Mg 2+ homeostasis in mammals

    Lillia V. Ryazanova;Lusliany J. Rondon;Susanna Zierler;Zhixian Hu

  • The TRPM ion channel subfamily: molecular, biophysical and functional features

    Andrea Fleig;Reinhold Penner

  • TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

    Ingo Lange;Ingo Lange;Shinichiro Yamamoto;Santiago Partida-Sanchez;Santiago Partida-Sanchez;Yasuo Mori

  • CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties

    Thomas Voets;Jean Prenen;Andrea Fleig;Rudi Vennekens

  • THE STORE-OPERATED CALCIUM CURRENT ICRAC : NONLINEAR ACTIVATION BY INSP3 AND DISSOCIATION FROM CALCIUM RELEASE

    Anant B Parekh;Andrea Fleig;Reinhold Penner

  • 2‐Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1‐dependent gating of CRAC channels

    Christine Peinelt;Annette Lis;Andreas Beck;Andrea Fleig

  • Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.

    Ryuichi Takezawa;Carsten Schmitz;Philippe Demeuse;Andrew M. Scharenberg

Frequent Co-Authors

Reinhold Penner
Reinhold Penner Queen's Medical Center
Andrew M. Scharenberg
Andrew M. Scharenberg Seattle Children's Hospital
Jean-Pierre Kinet
Jean-Pierre Kinet Beth Israel Deaconess Medical Center
Yasuo Mori
Yasuo Mori Kyoto University
Hiroshi Takeshima
Hiroshi Takeshima Kyoto University
Alan F. Cowman
Alan F. Cowman Walter and Eliza Hall Institute of Medical Research
Tomohiro Kurosaki
Tomohiro Kurosaki Osaka University
Barry V. L. Potter
Barry V. L. Potter University of Oxford
Masato Hirata
Masato Hirata Fukuoka Dental College
Bernhard Zabel
Bernhard Zabel University of Freiburg

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