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Microbiology

D-Index
56
Citations
9505
World Ranking
3738
National Ranking
1464

Overview

Kyeong-Ok Chang is affiliated with Kansas State University in the United States. Their primary research fields lie in Medicine, with a focus on Infectious Diseases, Computational Theory and Mathematics, Animal Science and Zoology, Molecular Biology, and Organic Chemistry.

Their scholarly contributions encompass multiple topics, including:

  • SARS-CoV-2 and COVID-19 Research
  • Viral gastroenteritis research and epidemiology
  • Computational Drug Discovery Methods
  • Animal Virus Infections Studies
  • Synthesis and biological activity
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing

Kyeong-Ok Chang has published extensively in venues such as:

  • Journal of Medicinal Chemistry
  • Microbiology Spectrum
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Proceedings of the National Academy of Sciences

Frequent collaborators in their work include Yunjeong Kim, Scott Lovell, William C. Groutas, Krishani Dinali Perera, and Chamandi S. Dampalla.

Representative recent publications include:

  • 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice, 2020, Science Translational Medicine
  • Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection, 2021, Proceedings of the National Academy of Sciences
  • Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease, 2021, Journal of Medicinal Chemistry
  • Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease, 2022, Journal of Medicinal Chemistry
  • SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City, 2022, Viruses

Best Publications

  • Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages

    Christiane E. Wobus;Stephanie M. Karst;Larissa B. Thackray;Kyeong Ok Chang

  • Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

    Yunjeong Kim;Scott Lovell;Kok Chuan Tiew;Sivakoteswara Rao Mandadapu

  • Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells.

    Stanislav V. Sosnovtsev;Gaël Belliot;Kyeong Ok Chang;Victor G. Prikhodko

  • Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

    Yunjeong Kim;Hongwei Liu;Anushka C. Galasiti Kankanamalage;Sahani Weerasekara

  • Inhibition of influenza virus replication by plant-derived isoquercetin

    Yunjeong Kim;Sanjeev Narayanan;Kyeong-Ok Chang

  • 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.

    Athri D. Rathnayake;Jian Zheng;Yunjeong Kim;Krishani Dinali Perera

  • Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis.

    Niels C Pedersen;Yunjeong Kim;Hongwei Liu;Anushka C. Galasiti Kankanamalage

  • Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1

    Kyeong-Ok Chang;Stanislav V. Sosnovtsev;Gaël Belliot;Yunjeong Kim

  • Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line

    Kyeong-Ok Chang;Stanislav V. Sosnovtsev;Gaël Belliot;Adriene D. King

  • Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells

    Kyeong-Ok Chang;David W. George

  • Cross-protection studies between respiratory and calf diarrhea and winter dysentery coronavirus strains in calves and RT-PCR and nested PCR for their detection

    K O Cho;M Hasoksuz;P R Nielsen;K O Chang

  • Feline calicivirus VP2 is essential for the production of infectious virions.

    Stanislav V. Sosnovtsev;Gaël Belliot;Kyeong-Ok Chang;Oge Onwudiwe

  • Calicivirus 3C-Like Proteinase Inhibits Cellular Translation by Cleavage of Poly(A)-Binding Protein

    Muge Kuyumcu-Martinez;Gaël Belliot;Stanislav V. Sosnovtsev;Kyeong-Ok Chang

  • Characterization of an enteropathogenic bovine calicivirus representing a potentially new calicivirus genus.

    J. R. Smiley;K. O. Chang;J. Hayes;J. Vinjé

  • Molecular Characterization of a Porcine Enteric Calicivirus Genetically Related to Sapporo-Like Human Caliciviruses

    M. Guo;K. O. Chang;M. E. Hardy;Q. Zhang

  • Intranasal Administration of 2/6-Rotavirus-Like Particles with Mutant Escherichia coli Heat-Labile Toxin (LT-R192G) Induces Antibody-Secreting Cell Responses but Not Protective Immunity in Gnotobiotic Pigs

    Lijuan Yuan;Annelise Geyer;Douglas C. Hodgins;Zhiqian Fan

  • Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

    Liang Zhang;Song Zhang;Izumi Maezawa;Sergey Trushin

  • Molecular characterization and pathogenesis of transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd.

    L. Kim;J. Hayes;P. Lewis;A. V. Parwani

  • Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response.

    Jeffrey W. Perry;Mohammad Ahmed;Kyeong Ok Chang;Nicholas J. Donato

  • Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

    Anushka C. Galasiti Kankanamalage;Yunjeong Kim;Vishnu C. Damalanka;Athri D. Rathnayake

  • Role of Cholesterol Pathways in Norovirus Replication

    Kyeong-Ok Chang

  • Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages.

    John B. Patton;Raymond Robert Richard Rowland;Dongwan Yoo;Kyeong Ok Chang

Frequent Co-Authors

Linda J. Saif
Linda J. Saif The Ohio State University
Kim Y. Green
Kim Y. Green National Institutes of Health
Stanislav V. Sosnovtsev
Stanislav V. Sosnovtsev National Institutes of Health
Lijuan Yuan
Lijuan Yuan Virginia Tech
Lee-Way Jin
Lee-Way Jin University of California, Davis
Maikel P. Peppelenbosch
Maikel P. Peppelenbosch Erasmus University Rotterdam
Niels C Pedersen
Niels C Pedersen University of California, Davis
Stanley Perlman
Stanley Perlman University of Iowa
Christiane E. Wobus
Christiane E. Wobus University of Michigan–Ann Arbor
Bror Morein
Bror Morein Swedish University of Agricultural Sciences

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