Chimeric antigen receptor, Antigen, Antigen-presenting cell, Cytotoxic T cell and Immunology are his primary areas of study. His research in Chimeric antigen receptor intersects with topics in Cancer research, CD28, Molecular biology, Adoptive cell transfer and CD19. In his study, which falls under the umbrella issue of Antigen, Effector, Function, Signal transduction and Epitope is strongly linked to Monoclonal antibody.
His Antigen-presenting cell research includes themes of Natural killer T cell, Lymphokine-activated killer cell and Cell biology. His Cytotoxic T cell course of study focuses on Immune system and Human leukocyte antigen, HEK 293 cells, Zinc finger nuclease and Cellular differentiation. His Immunology research is multidisciplinary, relying on both Hematopoietic stem cell transplantation and Transplantation.
Dean A. Lee spends much of his time researching Immunology, Cancer research, Cytotoxic T cell, Immunotherapy and Cell biology. The concepts of his Immunology study are interwoven with issues in Cell therapy and Transplantation. His study in Cancer research is interdisciplinary in nature, drawing from both Cell culture, Natural killer cell, NKG2D, Perforin and Interleukin 15.
His Cytotoxic T cell research integrates issues from Molecular biology, Antibody-dependent cell-mediated cytotoxicity and Antigen. His work on CD19 as part of general Antigen research is frequently linked to Transposase, bridging the gap between disciplines. His Adoptive cell transfer research focuses on Chimeric antigen receptor and how it relates to Genetic enhancement, CD28 and Virology.
Cancer research, Immunotherapy, Cytotoxic T cell, Cell therapy and Cell are his primary areas of study. His studies in Cancer research integrate themes in fields like Cancer, Immune system, NKG2D, Perforin and In vivo. His Cell therapy research is multidisciplinary, incorporating perspectives in Adoptive cell transfer and Immunology.
Dean A. Lee has researched Immunology in several fields, including Hematopoietic stem cell transplantation, Transplantation, Clinical trial and Homeostasis. His research integrates issues of Innate immune system, Cytotoxicity and Cell biology in his study of Cell. The Innate immune system study combines topics in areas such as Chimeric antigen receptor and CD3.
Dean A. Lee mainly investigates Immunotherapy, Cancer research, Cytotoxic T cell, Cancer and Cell. His Immunotherapy study is concerned with the larger field of Immune system. His study in Cancer research is interdisciplinary in nature, drawing from both Exome sequencing, Cell culture, Tumor microenvironment, Natural killer cell and In vivo.
His Cytotoxic T cell study incorporates themes from Ovarian cancer, Cell therapy and Cytotoxicity. His research on Cell also deals with topics like
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Tumor-specific human CD4+ regulatory T cells and their ligands: Implications for immunotherapy
Helen Yicheng Wang;Dean A. Lee;Guangyong Peng;Zhong Guo.
New insights to the MLL recombinome of acute leukemias
C. Meyer;E. Kowarz;J. Hofmann;A. Renneville.
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
Hiroki Torikai;Andreas Reik;Pei Qi Liu;Yuanyue Zhou.
Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells
Cecele J. Denman;Vladimir V. Senyukov;Srinivas S. Somanchi;Prasad V. Phatarpekar.
PLOS ONE (2012)
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells
Partow Kebriaei;Harjeet Singh;M. Helen Huls;Matthew J. Figliola.
Journal of Clinical Investigation (2016)
Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Hillary G. Caruso;Hillary G. Caruso;Lenka V. Hurton;Lenka V. Hurton;Amer Najjar;David Rushworth;David Rushworth.
Cancer Research (2015)
Similar transplantation outcomes for acute myeloid leukemia and myelodysplastic syndrome patients with haploidentical versus 10/10 human leukocyte antigen-matched unrelated and related donors.
Antonio Di Stasi;Denái R. Milton;L.M. Poon;Amir Hamdi.
Biology of Blood and Marrow Transplantation (2014)
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
Hiroki Torikai;Andreas Reik;Frank Soldner;Edus H. Warren.
T cells redirected to EphA2 for the immunotherapy of glioblastoma.
Kevin Kh Chow;Swati Naik;Sunitha Kakarla;Vita S. Brawley.
Molecular Therapy (2013)
Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy
David A. Knorr;Zhenya Ni;David L Lampi Hermanson;Melinda K. Hexum.
Stem Cells Translational Medicine (2013)
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