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Immunology

D-Index
62
Citations
14835
World Ranking
3126
National Ranking
1463

Overview

Dean A. Lee is affiliated with Nationwide Children's Hospital in the United States. The research primarily focuses on immune cell function, especially natural killer (NK) cells, and their applications in cancer and hematologic malignancies. Their body of work explores the roles and therapies involving NK cells, hematopoietic stem cell transplantation, and CAR-T cell therapy.

Frequent coauthors who have collaborated extensively with Dean A. Lee include Mitchell S. Cairo, Yaya Chu, Janet Ayello, Gregory K. Behbehani, and Meisam Naeimi Kararoudi.

Dean A. Lee has contributed to multiple publication venues with recurring appearances in Blood, Transplantation and Cellular Therapy, Cancer Research, Regular and Young Investigator Award Abstracts, and Molecular Therapy Oncology.

Their main fields of study cover Medicine and Immunology and Microbiology. Subfields include Immunology, Oncology, Molecular Biology, Hematology, and Genetics.

Main research topics associated with Dean A. Lee are:

  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Hematopoietic Stem Cell Transplantation
  • Virus-based gene therapy research
  • Acute Myeloid Leukemia Research
  • T-cell and B-cell Immunology
  • Neuroblastoma Research and Treatments

Recent notable papers authored or coauthored by Dean A. Lee include:

  • NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma, 2021, Blood Cancer Journal
  • CD38 deletion of human primary NK cells eliminates daratumumab-induced fratricide and boosts their effector activity, 2020, Blood
  • Decrease post-transplant relapse using donor-derived expanded NK-cells, 2021, Leukemia
  • Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma, 2020, Neuro-Oncology
  • Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future, 2021, Stem Cell Research & Therapy

Best Publications

  • Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

    Cecele J. Denman;Vladimir V. Senyukov;Srinivas S. Somanchi;Prasad V. Phatarpekar

  • Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands: Implications for Immunotherapy

    Helen Yicheng Wang;Dean A. Lee;Guangyong Peng;Zhong Guo

  • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

    Hiroki Torikai;Andreas Reik;Pei Qi Liu;Yuanyue Zhou

  • Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

    Partow Kebriaei;Harjeet Singh;M. Helen Huls;Matthew J. Figliola

  • New insights to the MLL recombinome of acute leukemias

    C. Meyer;E. Kowarz;J. Hofmann;A. Renneville

  • Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.

    Lenka V. Hurton;Lenka V. Hurton;Harjeet Singh;Amer M. Najjar;Kirsten C. Switzer

  • Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

    David A. Knorr;Zhenya Ni;David L Lampi Hermanson;Melinda K. Hexum

  • Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

    Hillary G. Caruso;Hillary G. Caruso;Lenka V. Hurton;Lenka V. Hurton;Amer Najjar;David Rushworth;David Rushworth

  • Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplantation.

    Stefan O. Ciurea;Jolie R. Schafer;Roland Bassett;Cecele J. Denman

  • Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

    Hiroki Torikai;Andreas Reik;Frank Soldner;Edus H. Warren

  • T cells redirected to EphA2 for the immunotherapy of glioblastoma.

    Kevin Kh Chow;Swati Naik;Sunitha Kakarla;Vita S. Brawley

  • Similar transplantation outcomes for acute myeloid leukemia and myelodysplastic syndrome patients with haploidentical versus 10/10 human leukocyte antigen-matched unrelated and related donors.

    Antonio Di Stasi;Denái R. Milton;L.M. Poon;Amir Hamdi

  • Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

    Pappanaicken R. Kumaresan;Pallavi R. Manuri;Nathaniel D. Albert;Sourindra Maiti

  • Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies

    Harjeet Singh;Matthew J. Figliola;Margaret J. Dawson;Helen Huls

  • Phase I study of cord blood-derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma.

    Nina Shah;Li Li;Jessica McCarty;Indreshpal Kaur

  • Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

    Nina Shah;Beatriz Martin-Antonio;Hong Yang;Stephanie Ku

  • Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

    Drew C Deniger;Kirsten Switzer;Tiejuan Mi;Sourindra Maiti

  • Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children.

    Charles S. Cox;James E. Baumgartner;Matthew T. Harting;Laura L. Worth

  • Chimeric Antigen Receptor (CAR)-Specific Monoclonal Antibody to Detect CD19-Specific T Cells in Clinical Trials

    Bipulendu Jena;Sourindra Maiti;Helen Huls;Harjeet Singh

  • Expansion, purification, and functional assessment of human peripheral blood NK cells.

    Srinivas S. Somanchi;Vladimir V. Senyukov;Cecele J. Denman;Dean A. Lee

Frequent Co-Authors

Laurence J.N. Cooper
Laurence J.N. Cooper The University of Texas MD Anderson Cancer Center
Richard E. Champlin
Richard E. Champlin The University of Texas MD Anderson Cancer Center
Elizabeth J. Shpall
Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center
Partow Kebriaei
Partow Kebriaei The University of Texas MD Anderson Cancer Center
Mitchell S. Cairo
Mitchell S. Cairo New York Medical College
Hing C. Wong
Hing C. Wong Georgia State University
Katayoun Rezvani
Katayoun Rezvani The University of Texas MD Anderson Cancer Center
Catherine M. Bollard
Catherine M. Bollard George Washington University
Ali A. Ashkar
Ali A. Ashkar McMaster University
Perry B. Hackett
Perry B. Hackett University of Minnesota

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