What is he best known for?
The fields of study he is best known for:
- Cancer
- Gene
- Immune system
Chimeric antigen receptor, Antigen, Antigen-presenting cell, Cytotoxic T cell and Immunology are his primary areas of study.
His research in Chimeric antigen receptor intersects with topics in Cancer research, CD28, Molecular biology, Adoptive cell transfer and CD19.
In his study, which falls under the umbrella issue of Antigen, Effector, Function, Signal transduction and Epitope is strongly linked to Monoclonal antibody.
His Antigen-presenting cell research includes themes of Natural killer T cell, Lymphokine-activated killer cell and Cell biology.
His Cytotoxic T cell course of study focuses on Immune system and Human leukocyte antigen, HEK 293 cells, Zinc finger nuclease and Cellular differentiation.
His Immunology research is multidisciplinary, relying on both Hematopoietic stem cell transplantation and Transplantation.
His most cited work include:
- Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands: Implications for Immunotherapy (490 citations)
- A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. (376 citations)
- A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. (376 citations)
What are the main themes of his work throughout his whole career to date?
Dean A. Lee spends much of his time researching Immunology, Cancer research, Cytotoxic T cell, Immunotherapy and Cell biology.
The concepts of his Immunology study are interwoven with issues in Cell therapy and Transplantation.
His study in Cancer research is interdisciplinary in nature, drawing from both Cell culture, Natural killer cell, NKG2D, Perforin and Interleukin 15.
His Cytotoxic T cell research integrates issues from Molecular biology, Antibody-dependent cell-mediated cytotoxicity and Antigen.
His work on CD19 as part of general Antigen research is frequently linked to Transposase, bridging the gap between disciplines.
His Adoptive cell transfer research focuses on Chimeric antigen receptor and how it relates to Genetic enhancement, CD28 and Virology.
He most often published in these fields:
- Immunology (40.89%)
- Cancer research (37.80%)
- Cytotoxic T cell (26.46%)
What were the highlights of his more recent work (between 2017-2021)?
- Cancer research (37.80%)
- Immunotherapy (23.37%)
- Cytotoxic T cell (26.46%)
In recent papers he was focusing on the following fields of study:
Cancer research, Immunotherapy, Cytotoxic T cell, Cell therapy and Cell are his primary areas of study.
His studies in Cancer research integrate themes in fields like Cancer, Immune system, NKG2D, Perforin and In vivo.
His Cell therapy research is multidisciplinary, incorporating perspectives in Adoptive cell transfer and Immunology.
Dean A. Lee has researched Immunology in several fields, including Hematopoietic stem cell transplantation, Transplantation, Clinical trial and Homeostasis.
His research integrates issues of Innate immune system, Cytotoxicity and Cell biology in his study of Cell.
The Innate immune system study combines topics in areas such as Chimeric antigen receptor and CD3.
Between 2017 and 2021, his most popular works were:
- Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target (54 citations)
- Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models (43 citations)
- Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells (29 citations)
In his most recent research, the most cited papers focused on:
- Cancer
- Gene
- Immune system
Dean A. Lee mainly investigates Immunotherapy, Cancer research, Cytotoxic T cell, Cancer and Cell.
His Immunotherapy study is concerned with the larger field of Immune system.
His study in Cancer research is interdisciplinary in nature, drawing from both Exome sequencing, Cell culture, Tumor microenvironment, Natural killer cell and In vivo.
His Cytotoxic T cell study incorporates themes from Ovarian cancer, Cell therapy and Cytotoxicity.
His research on Cell also deals with topics like
- Cell biology together with K562 cells,
- Protein kinase A which connect with Cytokine.
His Cytokine study is related to the wider topic of Immunology.
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