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Biology and Biochemistry

D-Index
49
Citations
13572
World Ranking
17859
National Ranking
1409

Overview

Frederick J. Livesey is affiliated with University College London in the United Kingdom. Their research spans several fields, primarily Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience, with a focus on specialized subfields such as Physiology, Molecular Biology, Cell Biology, Genetics, and Neurology.

Their main topics of research include Alzheimer's disease research and treatments, cellular transport and secretion, genetics and neurodevelopmental disorders, neuroinflammation and neurodegeneration mechanisms, tryptophan and brain disorders, RNA research and splicing, and microtubule and mitosis dynamics.

Livesey has contributed to multiple publication venues, with a notable presence in bioRxiv (Cold Spring Harbor Laboratory), where seven publications have appeared. Other frequent venues include Cell Reports with three publications, Brain Communications also with three, Biological Psychiatry with two, and Autophagy with one publication.

Among recent papers authored or co-authored by Livesey, the following are prominent:

  • Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways, 2020, Cell Reports
  • SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network, 2021, Cell Reports
  • Endolysosome and autophagy dysfunction in Alzheimer disease, 2021, Autophagy
  • Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons, 2020, Brain Communications
  • APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease, 2024, Brain

Livesey frequently collaborates with other researchers, including Christy Hung, Alessio Strano, Rickie Patani, Moritz Haneklaus, and Francesco Paonessa.

Best Publications

  • Vertebrate neural cell-fate determination: Lessons from the retina

    F. J. Livesey;C. L. Cepko

  • Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

    Yichen Shi;Peter Kirwan;Frederick J Livesey

  • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

    Yichen Shi;Peter Kirwan;James Smith;Hugh P C Robinson

  • G&T-seq: parallel sequencing of single-cell genomes and transcriptomes

    Iain C Macaulay;Wilfried Haerty;Parveen Kumar;Yang I Li;Yang I Li

  • Guided self-organization and cortical plate formation in human brain organoids

    Madeline A Lancaster;Madeline A Lancaster;Nina S Corsini;Simone Wolfinger;E Hilary Gustafson

  • A role for Dicer in immune regulation.

    Bradley S Cobb;Arnulf Hertweck;James P Smith;Eric D. O'Connor

  • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

    João D. Pereira;Stephen N. Sansom;James Smith;Marc-Werner Dobenecker

  • Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina

    Michael A. Dyer;Frederick J. Livesey;Frederick J. Livesey;Constance L. Cepko;Guillermo Oliver

  • The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

    Stephen N. Sansom;Dean S. Griffiths;Andrea Faedo;Dirk-Jan Kleinjan

  • η-Secretase processing of APP inhibits neuronal activity in the hippocampus

    Michael Willem;Sabina Tahirovic;Marc Aurel Busche;Marc Aurel Busche;Saak V. Ovsepian

  • A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

    Yichen Shi;Peter Kirwan;James Smith;Glenn MacLean

  • Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx.

    F.J. Livesey;F.J. Livesey;T. Furukawa;T. Furukawa;M.A. Steffen;G.M. Church

  • 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

    Tomoki Otani;Maria C. Marchetto;Fred H. Gage;Benjamin D. Simons

  • Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerebellar development.

    F.J. Livesey;S.P. Hunt

  • APP metabolism regulates tau proteostasis in human cerebral cortex neurons

    Steven James Moore;Lewis D Evans;Therése Andersson;Erik Portelius

  • A Schwann cell mitogen accompanying regeneration of motor neurons.

    Frederick J. Livesey;Frederick J. Livesey;John A. O'Brien;Meng Li;Austin G. Smith

  • Chromatin regulation by BAF170 controls cerebral cortical size and thickness.

    Tran Cong Tuoc;Susann Boretius;Stephen N. Sansom;Mara-Elena Pitulescu

  • Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex

    Stephen N. Sansom;Frederick J. Livesey

  • Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

    Lewis David Evans;Thomas Wassmer;Graham Fraser;James Smith

  • Developmental regulation of tau splicing is disrupted in stem cell derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT

    Teresa Sposito;Elisavet Preza;Colin J. Mahoney;Núria Setó-Salvia

Frequent Co-Authors

James C. Smith
James C. Smith The Francis Crick Institute
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Constance L. Cepko
Constance L. Cepko Harvard University
Vincent Torre
Vincent Torre International School for Advanced Studies
John Hardy
John Hardy University College London
Hugh P. C. Robinson
Hugh P. C. Robinson University of Cambridge
Kaj Blennow
Kaj Blennow University of Gothenburg
Erik Portelius
Erik Portelius Sahlgrenska University Hospital
Benjamin D. Simons
Benjamin D. Simons University of Cambridge

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