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Mitchell P. Levesque

Mitchell P. Levesque

D-Index & Metrics

Molecular Biology

D-Index
59
Citations
16253
World Ranking
2005
National Ranking
33

Overview

Mitchell P. Levesque is affiliated with the University of Zurich in Switzerland. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Oncology, Immunology, Dermatology, and Cancer Research as subfields.

Levesque's work covers a range of topics within cancer and immunology research. The main focuses include Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Melanoma and MAPK Pathways, CAR-T cell therapy research, Cutaneous Melanoma Detection and Management, Cutaneous lymphoproliferative disorders research, and Single-cell and spatial transcriptomics.

Selected recent publications highlight the scope of their work:

  • Identification of bacteria-derived HLA-bound peptides in melanoma, 2021, Nature
  • Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy, 2022, Science Immunology
  • Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity, 2020, Nature Communications
  • Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state, 2020, Nature Medicine
  • Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma, 2021, Cancer Cell

Levesque frequently collaborates with several researchers, including Reinhard Dummer, Phil F. Cheng, Patrick Turko, Aizhan Tastanova, and Egle Ramelyte. These collaborations are reflected in numerous coauthored publications.

Their work is often published in several key academic venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Cancers, Nature Communications, and the Journal of Investigative Dermatology.

Best Publications

  • Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Vasanthi S. Viswanathan;Matthew J. Ryan;Harshil D. Dhruv;Shubhroz Gill

  • Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

    Meghna Das Thakur;Fernando Salangsang;Allison S. Landman;William R. Sellers

  • High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

    Carsten Krieg;Malgorzata Nowicka;Malgorzata Nowicka;Silvia Guglietta;Sabrina Schindler

  • An Evolutionarily Conserved Mechanism Delimiting SHR Movement Defines a Single Layer of Endodermis in Plants

    Hongchang Cui;Mitchell P. Levesque;Teva Vernoux;Jee W. Jung

  • Toward Minimal Residual Disease-Directed Therapy in Melanoma.

    Florian Rambow;Aljosja Rogiers;Oskar Marin-Bejar;Sara Aibar

  • Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root.

    Ive De Smet;Ive De Smet;Ive De Smet;Valya Vassileva;Valya Vassileva;Bert De Rybel;Bert De Rybel;Mitchell P. Levesque

  • Identification of bacteria-derived HLA-bound peptides in melanoma

    Shelly Kalaora;Adi Nagler;Deborah Nejman;Michal Alon

  • Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis

    Mitchell P Levesque;Teva Vernoux;Wolfgang Busch;Hongchang Cui

  • CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets

    Malgorzata Nowicka;Malgorzata Nowicka;Carsten Krieg;Helena L. Crowell;Helena L. Crowell;Lukas M. Weber;Lukas M. Weber

  • The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

    Daniel Zingg;Julien Debbache;Simon M. Schaefer;Eylul Tuncer

  • Bimodular auxin response controls organogenesis in Arabidopsis

    Ive De Smet;Steffen Lau;Ute Voß;Steffen Vanneste

  • Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

    Karīna Siliņa;Alex Soltermann;Farkhondeh Movahedian Attar;Ruben Casanova

  • Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.

    Felicity Newell;Yan Kong;James S. Wilmott;Peter A. Johansson

  • Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

    Michael P. Smith;Holly Brunton;Emily J. Rowling;Jennifer Ferguson

  • Predictors of responses to immune checkpoint blockade in advanced melanoma.

    N Jacquelot;N Jacquelot;M P Roberti;D P Enot;S Rusakiewicz

  • IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.

    Emmanuella Guenova;Emmanuella Guenova;Yuliya Skabytska;Wolfram Hoetzenecker;Wolfram Hoetzenecker;Günther Weindl;Günther Weindl

  • Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.

    Daniel S. Widmer;Keith S. Hoek;Phil F. Cheng;Ossia M. Eichhoff

  • Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice

    Yan Li;Roberto Tinoco;Roberto Tinoco;Lisa Elmén;Igor Segota

  • Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages

    Roman Huber;Barbara Meier;Atsushi Otsuka;Gabriele Fenini

  • Mutations in C10orf11, a Melanocyte-Differentiation Gene, Cause Autosomal-Recessive Albinism

    Karen Grønskov;Karen Grønskov;Christopher M. Dooley;Elsebet Østergaard;Robert N. Kelsh

Frequent Co-Authors

Reinhard Dummer
Reinhard Dummer University of Zurich
Mark D. Robinson
Mark D. Robinson University of Zurich
Lukas Sommer
Lukas Sommer University of Zurich
G. Paolo Dotto
G. Paolo Dotto Harvard University
Dennie T. Frederick
Dennie T. Frederick Broad Institute
Bernd Bodenmiller
Bernd Bodenmiller University of Zurich
Philip N. Benfey
Philip N. Benfey Duke University
David J. Adams
David J. Adams Wellcome Sanger Institute

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