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Molecular Biology

D-Index
56
Citations
21275
World Ranking
2178
National Ranking
172

Overview

Lorna W. Harries is affiliated with the University of Exeter in the United Kingdom and focuses their research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans molecular biology, physiology, cancer research, infectious diseases, and surgery, with a significant emphasis on molecular mechanisms and biological aging processes.

The main topics covered in their research include:

  • Telomeres, Telomerase, and Senescence
  • RNA Research and Splicing
  • Genetics, Aging, and Longevity in Model Organisms
  • Glycosylation and Glycoproteins Research
  • Ubiquitin and Proteasome Pathways
  • SARS-CoV-2 and COVID-19 Research
  • Cancer-related Molecular Mechanisms Research

Lorna W. Harries has published extensively, with recent papers that highlight diverse but interconnected biomedical topics. Recent publications include:

  • Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth (2023, Oncogene)
  • Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation (2020, GeroScience)
  • <scp>ST6GAL1</scp>-mediated aberrant sialylation promotes prostate cancer progression (2023, The Journal of Pathology)
  • Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic (2022, Gut)
  • Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood (2020, BMC Medical Genomics)

The scientist collaborates frequently with colleagues including Laura R. Bramwell, Bridget Knight, John McGrath, Merlin Davies, and Ryan Frankum. These collaborations have contributed to a number of publications particularly in the areas of aging, molecular biology, and disease mechanisms.

Their work is regularly published in journals such as:

  • GeroScience
  • ALTEX
  • Preprints.org
  • Oncogene
  • The Journal of Pathology

Best Publications

  • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

    Timothy M. Frayling;Nicholas J. Timpson;Michael N. Weedon;Eleftheria Zeggini;Eleftheria Zeggini;Eleftheria Zeggini

  • Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

    Eleftheria Zeggini;Michael N. Weedon;Cecilia M. Lindgren;Timothy M. Frayling

  • Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.

    L. W. Harries;M. J. Stubbins;D. Forman;G. C. W. Howard

  • Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

    Katie Lunnon;Rebecca Smith;Eilis Hannon;Philip L De Jager

  • Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.

    D Ryberg;V Skaug;A Hewer;D H Phillips

  • Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

    K. Zhou;K. Zhou;C. Bellenguez;C.C.A. Spencer;A.J. Bennett

  • Genetic analysis of the human cytochrome P450 CYP2C9 locus.

    M J Stubbins;L W Harries;G Smith;M H Tarbit

  • Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.

    Sarah E. Flanagan;Séverine Clauin;Christine Bellanné-Chantelot;Pascale de Lonlay

  • Long non-coding RNAs and human disease.

    Lorna W. Harries

  • Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

    Lorna W. Harries;Dena Hernandez;William Henley;Andrew R. Wood

  • HNF1B Mutations Associate with Hypomagnesemia and Renal Magnesium Wasting

    Shazia Adalat;Adrian S. Woolf;Karen A. Johnstone;Andrea Wirsing

  • Circular RNAs (circRNAs) in Health and Disease

    Shahnaz Haque;Lorna W Harries

  • Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.

    Sian Ellard;Sarah E. Flanagan;Christophe A. Girard;Ann-Marie Patch

  • Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis

    Intza Garin;Emma L. Edghill;Ildem Akerman;Oscar Rubio-Cabezas

  • Molecular genetics of the human cytochrome P450 monooxygenase superfamily

    G Smith;M J Stubbins;L W Harries;C R Wolf

  • Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.

    Luke C. Pilling;Chia-Ling Kuo;Kamil Sicinski;Jone Tamosauskaite

  • Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans.

    Tony Fletcher;Tamara S. Galloway;David Melzer;Paul Holcroft

  • Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.

    Lorna W. Harries;Sian Ellard;Amanda Stride;Noel G. Morgan

  • The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.

    C. Matthias;U. Bockmühl;V. Jahnke;L. W. Harries

  • Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

    Luke C. Pilling;Janice L. Atkins;Kirsty Bowman;Samuel E. Jones

Frequent Co-Authors

David Melzer
David Melzer University of Exeter
Sian Ellard
Sian Ellard University of Exeter
Andrew T. Hattersley
Andrew T. Hattersley University of Exeter
Luigi Ferrucci
Luigi Ferrucci National Institutes of Health
Timothy M. Frayling
Timothy M. Frayling University of Geneva
Stefania Bandinelli
Stefania Bandinelli University of Michigan–Ann Arbor
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Andrew R. Wood
Andrew R. Wood University of Exeter
Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Michael N. Weedon
Michael N. Weedon University of Exeter

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