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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
13728
World Ranking
10248
National Ranking
4471

Overview

Lynn E. Heasley is affiliated with the University of Colorado Anschutz Medical Campus in the United States. The research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a significant focus on Oncology, Molecular Biology, Immunology, Pulmonary and Respiratory Medicine, and Pathology and Forensic Medicine.

The scientist's work addresses several main topics, including:

  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Treatments and Mutations
  • Immunotherapy and Immune Responses
  • Lung Cancer Research Studies
  • Cytokine Signaling Pathways and Interactions
  • Cancer Cells and Metastasis
  • Immune Cell Function and Interaction

Frequent publication venues for Lynn E. Heasley include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • npj Precision Oncology
  • Journal of Thoracic Oncology
  • Frontiers in Oncology

Notable recent papers demonstrate a focus on lung cancer and immune microenvironment interactions. Key publications include:

  • Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma, 2020, The Journal of Immunology
  • Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms, 2020, Journal for ImmunoTherapy of Cancer
  • A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer, 2021, npj Precision Oncology
  • Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment, 2021, Journal of Thoracic Oncology
  • Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response, 2021, Journal of Translational Medicine

Frequent coauthors of Lynn E. Heasley include:

  • Raphael A. Nemenoff
  • Trista K. Hinz
  • Andre Navarro
  • Erin L. Schenk
  • Eric T. Clambey

The scientist's work largely revolves around the molecular mechanisms of cancer, particularly lung cancer, and the immune system's role in tumor response, as well as therapeutic interventions targeting these pathways. The research contributions contribute to ongoing studies on immune responses and tumor microenvironments, particularly with regard to major histocompatibility complex expression and therapeutic responses in oncology.

Best Publications

  • Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non-Small Cell Lung Cancer

    Robert C. Doebele;Amanda B. Pilling;Dara L. Aisner;Tatiana G. Kutateladze

  • Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

    Subbiah Pugazhenthi;Albina Nesterova;Albina Nesterova;Carol Sable;Kim A. Heidenreich

  • Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

    Raphael A. Nemenoff;Sim Winitz;Nan Xin Qian;Vicki Van Putten

  • Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells

    Lindsay Marek;Kathryn E. Ware;Alexa Fritzsche;Paula Hercule

  • MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.

    S K Gupta;C Gallego;G L Johnson;L E Heasley

  • Synergistic Effects of New Chemopreventive Agents and Conventional Cytotoxic Agents against Human Lung Cancer Cell Lines

    Ariel F. Soriano;Barbara Helfrich;Daniel C. Chan;Lynn E. Heasley

  • G protein-coupled receptor systems involved in cell growth and oncogenesis

    N. Dhanasekaran;Lynn E. Heasley;Gary L. Johnson

  • A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

    Ware Ke;Hinz Tk;Kleczko E;Singleton Kr

  • Autocrine and paracrine signaling through neuropeptide receptors in human cancer

    Lynn E Heasley

  • Activation of Jun kinase/stress-activated protein kinase by GTPase- deficient mutants of Gα12 and Gα13

    M. V. V. S. Vara Prasad;Jonathan M. Dermott;Lynn E. Heasley;Gary L. Johnson

  • Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells*

    Lynn E. Heasley;Gary L. Johnson

  • Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration

    Ayman Oweida;Mohammad Hararah;Andy V Phan;David C. Binder

  • Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer

    Lynn E. Heasley;Seth Thaler;Michael Nicks;Brenda Price

  • Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer.

    Rachel M.A. Linger;Rebecca A. Cohen;Christopher T. Cummings;Susan Sather

  • Restoration of Wnt-7a Expression Reverses Non-small Cell Lung Cancer Cellular Transformation through Frizzled-9-mediated Growth Inhibition and Promotion of Cell Differentiation

    Robert A. Winn;Robert A. Winn;Lindsay Marek;Sun-Young Han;Karen Rodriguez

  • The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

    Lynn E. Heasley;Gary L. Johnson

  • Peroxisome Proliferator-Activated Receptor-γ Is a Target of Nonsteroidal Anti-Inflammatory Drugs Mediating Cyclooxygenase-Independent Inhibition of Lung Cancer Cell Growth

    Marilee Wick;Greg Hurteau;Christina Dessev;Daniel Chan

  • c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation

    Laura Butterfield;Brooke Storey;Lara Maas;Lynn E. Heasley

  • The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade

    Howard Y Li;Maria V McSharry;Bonnie Bullock;Teresa T Nguyen

  • Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.

    Kathryn E. Ware;Marianne E. Marshall;Lydia R. Heasley;Lindsay Marek

Frequent Co-Authors

Raphael A. Nemenoff
Raphael A. Nemenoff University of Colorado Anschutz Medical Campus
Aik Choon Tan
Aik Choon Tan University of Utah
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill
Paul A. Bunn
Paul A. Bunn University of Colorado Boulder
Gary L. Johnson
Gary L. Johnson University of North Carolina at Chapel Hill
Sven Perner
Sven Perner University of Lübeck
James DeGregori
James DeGregori University of Colorado Anschutz Medical Campus
Wilbur A. Franklin
Wilbur A. Franklin University of Colorado Denver
D. Ross Camidge
D. Ross Camidge University of Colorado Anschutz Medical Campus
Antonio Jimeno
Antonio Jimeno University of Colorado Boulder

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